Section of Pharmacology

Unit of Pharmacology, Therapeutics and Pharmacognosy

Camins Espuny, Antonio

Grup de Recerca en Neurofarmacologia: Prevenció de l'envelliment (GREN)

GRUP DE RECERCA EN NEUROFARMACOLOGIA: PREVENCIÓ DE L'ENVELLIMENT (GREN)

Research Lines

Areas of Experience

1) The mouse SAMP8 is used as a model of Alzheimer.

2) Treatments such as melatonin and resveratrol as possible therapeutic strategies in aging and neurodegenerative diseases.

3) Array analysis.

4) Routes of neuronal death after in neurodegenerative diseases.

5) Neuronal cell

6) Development of new drugs for Alzheimer’s disease treatment.

Research Projects

Publications from the last three years

Camins A, Sureda FX, Junyent F, Verdaguer E, Folch J, Beas-Zarate C, Pallas M. An overview of investigational antiapoptotic drugs with potential application for the treatment of neurodegenerative disorders. Expert Opin Investig Drugs. 2010;19:587-604.

Pizarro JG, Folch J, de la Torre AV, Junyent F, Verdaguer E, Jordan J, Pallas  M, Camins A. ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation. J Cell Biochem. 2010 May;110(1):210-8.

Junyent F, De Lemos L, Utrera J, Paco S, Aguado F, Camins A, Pallàs M, Romero R, Auladell C. Content and traffic of taurine in hippocampal reactive astrocytes. Hippocampus. 2010 Jan 15.

Del Valle J, Duran-Vilaregut J, Manich G, Casadesús G, Smith MA, Camins A, Pallàs M, Pelegrí C, Vilaplana J. Early amyloid accumulation in the hippocampus of SAMP8 mice. J Alzheimers Dis. 2010; 19(4):1303-15.

Duque MD, Camps P, Torres E, Valverde E, Sureda FX, López-Querol M, Camins A,  Prathalingam SR, Kelly JM, Vázquez S. New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities. Bioorg Med Chem. 2010; 18:46-57.

Utrera J, Junyent F, de Lemos L, Pallàs M, Camins A, Romero R, Auladell C. Tau hyperphosphorylation and axonal damage induced by N,N-diethyldithiocarbamate (DEDTC) treatment along late postnatal development is followed by a rescue during adulthood. J Neurosci Res. 2010;88:1083-93.

Folch J, Alvira D, López-Querol M, Tajes M, Sureda FX, Forsby A, Rimbau V, Camins A, Pallàs M. Evaluation of transcriptional activity of caspase-3 gene as a marker of acute neurotoxicity in rat cerebellar granular cells. Toxicol In Vitro. 2010;24:465-71.

Junyent F, Romero R, de Lemos L, Utrera J, Camins A, Pallàs M, Auladell C. Taurine treatment inhibits CaMKII activity and modulates the presence of calbindin D28k, calretinin, and parvalbumin in the brain. J Neurosci Res. 2010;88:136-42.

Crespo-Biel N, Camins A, Pallàs M, Canudas AM. Evidence of calpain/cdk5 pathway inhibition by lithium in 3-nitropropionic acid toxicity in vivo and in vitro. Neuropharmacology. 2009 Feb;56(2):422-8.

Del Valle J, Duran-Vilaregut J, Manich G, Camins A, Pallàs M, Vilaplana J et al. Time-course of blood-brain barrier disruption in senescence-accelerated mouse prone 8 (SAMP8) mice. Int J Dev Neurosci. 2009 Feb;27(1):47-52.

Camins A, Verdaguer E, Alvira D, Rimbau V, Folch J, Pallàs M. E2F-1 (E2 promoter-binding factor 1): A common convergent point in neuronal apoptosis. In: Yoshida K, editor. Control of cellular physiology by E2F transcription factors. Research Signpost. India. 2009;p. 271-286.

Camins A, Pelegri C, Vilaplana J, Cristofol R, Sanfeliu C, PallàsM.  Sirtuin and Resveratrol. In: Packer L, Sies H, Eggersdorfer M, Cadenas E, editors. CRC Press. 2009.

Yeste-Velasco M, Folch J, Pallàs M, Camins A. The p38(MAPK) signaling pathway regulates neuronal apoptosis through the phosphorylation of the retinoblastoma protein. Neurochem Int. 2009 Feb;54(2):99-105.

Lee HG, Zhu X, Casadesus G, Pallàs M, Camins A, O'Neill MJ et al. The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival. Brain Res. 2009 Jan 16;1249:244-50.

Caballero B, Vega-Naredo I, Sierra V, Huidobro-Fernández C, Soria-Valles C, De Gonzalo-Calvo D et al. Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice. J Pineal Res. 2009 Jan ;46(1):106-14.

Forsby A, Bal-Price AK, Camins A, Coecke S, Fabre N, Gustafsson H et al. Neuronal in vitro models for the estimation of acute systemic toxicity. Toxicol In Vitro. 2009;23:1564-9.

Tajes Orduña M, Pelegrí Gabalda C, Vilaplana Hortensi J, Pallàs Lliberia M, Camins Espuny A. An evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis. J Pineal Res. 2009 Apr;46(3):262-7.

Tajes M, Gutierrez-Cuesta J, Ortuño-Sahagun D, Camins A, Pallàs M. Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway. J Pineal Res. 2009 ;47(3):228-37.

Junyent F, Utrera J, Camins A, Pallàs M, Romero R, Auladell C. Synthesis, uptake and release of taurine in astrocytes treated with 8-Br-cAMP. Neurosci Lett. 2009;467(3):199-202.

Pizarro JG, Folch J, Esparza JL, Jordan J, Pallàs M, Camins A. A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286. J Cell Mol Med. 2009 Sep;13(9B):3906-17.

Camins A, Verdaguer E, Junyent F, Yeste-Velasco M, Pelegrí C, Vilaplana J et al. Potential mechanisms involved in the prevention of neurodegenerative diseases by lithium. CNS Neurosci Ther. 2009 Winter;15(4):333-44.

Pizarro JG, Folch J, Vazquez De la Torre A, Verdaguer E, Junyent F, Jordán J et al. Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line. Free Radic Res. 2009;43:985-94.

Tajes M, Gutierrez-Cuesta J, Ortuño-Sahagun D, Camins A, Pallàs M. Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway. J Pineal Res. 2009 Oct;47(3):228-37.

Castillo CA, Albasanz JL, León D, Jordán J, Pallàs M, Camins A et al. Age-related expression of adenosine receptors in brain from the senescence-accelerated mouse.Exp Gerontol. 2009 Jun-Jul;44(6-7):453-61.

Folch J, Yeste-Velasco M, Alvira D, de la Torre AV, Bordas M, López M et al. Evaluation of pathways involved in pentachlorophenol-induced apoptosis in rat neurons. Neurotoxicology. 2009 May;30(3):451-8.

Forsby A, Bal-Price AK, Camins A, Coecke S, Fabre N, Gustafsson H et al. Neuronal in vitro models for the estimation of acute systemic toxicity. Toxicol In Vitro. 2009 Dec;23(8):1564-9.

Pallàs M, Casadesús G, Smith MA, Coto-Montes A, Pelegri C, Vilaplana J et al. Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection. Curr Neurovasc Res. 2009 Feb;6(1):70-81.

Yeste-Velasco M, Folch J, Casadesús G, Smith MA, Pallàs M, Camins A. Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry. Neuroscience. 2009 Mar 31;159(3):1135-47.

Tajes M, Yeste-Velasco M, Zhu X, Chou SP, Smith MA, Pallàs M et al. Activation of Akt by lithium: pro-survival pathways in aging. Mech Ageing Dev. 2009 Apr;130(4):253-61.

PhD theses submitted in the last three years

Collaborations with other research groups

Gemma Casadesús y Mark Smith (Case University, Cleveland USA)

Carlos Beas Zárate (Universidad de Guadalajara, México)

Daniel Ortuño Sahagún (Universidad de Guadalajara, México)

Coral Sanfeliu (CSIC)

Alberto Jorge Lazarowski (UNIVERSIDAD DE BUENOS AIRES).
Esper Abrao Cavalheiro (UNIVERSIDADE FEDERAL DE SÃO PAULO)

Manuel Gabriel Campos Puebla (CLÍNICA LAS CONDES, CENTRO AVANZADO DE EPILEPSIAS, Chile)

Lilia Maria Morales Chacón (CENTRO INTERNACIONAL DE RESTAURACIÓN NEUROLÓGICA (CIREN), Cuba)

Pietro Luigi Fagiolino Sabbatani (UNIVERSIDAD DE LA REPUBLICA (UDELAR), Uruguay)

Jaume Folch López Universitat Rovira i Virgili

Francesc Sureda Batlle Universitat Rovira i Virgili

Anna Forsby (Universidad de Estocolmo, Suecia)

Carme Auladell (Universidad de Barcelona)

Carme Pelegrí (Universidad de Barcelona)

Jordi Vilaplana (Universidad de Barcelona)

Isidre Ferrer (Universidad de Ba

Group members

Antonio Camins Espuny. Associate Professor-Principal Investigator.

Merce Pallàs LLiberia. Associate Professor-Principal Investigator.

Víctor Rimbau Barreras. Associate Professor

Andrés Jiménez Guerrero. Profesor Asociado

Anna María Canudas. Profesor lector. Reader.

Ester Verdaguer Cardona. Postdoctoral fellow.

Félix Junyent Herea. Postdoctoral fellow. CIBERNED

Aurelio Vázquez de la Torre Cervera. PhD student.

Sergi Ballot (Fellow)