Institut de Biomedicina de la Universitat de Barcelona
Drug and target discovery for biomedical science
The Institute of Biomedicine of the University of Barcelona (IBUB) is a transversal research unit formed by some 40 groups from the Faculties of Biology, Chemistry and Pharmacy and Food Sciences. The IBUB was created in 2006 with the aim of identifying, beyond the traditional academic structures (departments and faculties), a set of laboratories with complementary scientific activity, capable of generating synergies.
Technology Transfer Opportunities
One of the key strengths of IBUB is its ability to successfully transfer knowledge to society
CANCELLED – Functional role of extracellular vesicles in the dynamic dialogue between metabolic tissues in obesityMaría Pardos (IDIS)
DateFebruary 16, 2024
PlaceAula Graus, F. Biology
Supramolecular Chemical Biology: from Curiosity-Driven Research to Biomedical ApplicationsIgnacio Alfonso, IQAC-CSIC
DateJanuary 29, 2024
PlaceB-107, Pharmacy Fac.
Screening and identification of browning inducing polyphenols in human adipocytesIrene Pomares, IDiBE, UMH, Elche
DateJanuary 22, 2024
PlaceA15, Fac. Biology
Article of the month
Sara Soriano-Meseguer, Elisabet Fuguet, Adriana Port, Martí Rosés
Ability of biomimetic chromatography and physicochemical systems to predict the skin permeation of neutral compounds. A comparison study
Five in vitro physicochemical systems have been evaluated in terms of its ability to emulate the skin permeation of neutral compounds: the permeation in two different PAMPA membranes, the classical octanol-water partition coefficient, and two biomimetic chromatography systems, one based in cerasome electrokinetic chromatography and another based in reversed-phase liquid chromatography measurements.
The coefficients of the solvation parameter model equation of the mentioned systems have been compared to the ones of the skin permeation process through different comparison parameters. Moreover, a method to predict whether a physicochemical system is able to emulate satisfactorily a biological one, just by the analysis of the equation coefficients has been developed. Results reveal that the two PAMPA systems are a good choice to emulate directly the skin permeation of neutral compounds. Instead, the other three systems need a volume correction term to provide a satisfactory emulation. However, after the correction, all the evaluated systems show a similar ability to emulate well skin permeation, as predicted.