Biologia Vascular

teixit vascular microscópic

La nostra investigació se centra en la comprensió dels mecanismes cel·lulars i moleculars que controlen la formació i la funció dels vasos sanguinis. Els grans esforços se centren a desentranyar els mecanismes que controlen l’adhesió de cèl·lules-matriu i cèl·lula-cèl·lula de les cèl·lules endotelials. Per assolir els nostres objectius, fem servir un enfocament interdisciplinari que inclou eines genètiques de ratolí, models de cultiu cel·lular, assajos de biologia molecular, enfocaments de biologia de sistemes i microscòpia de fluorescència d’alta resolució. Els projectes en curs se centren en el paper de la senyalització mediada per integrina en la funció de barrera hematoencefàlica, disfuncions vasculars oculars i angiogènesi tumoral.

  • Eloi Montañez Miralles, Profesor Agregat  IP i responsable del grup  emontanez@ub.edu

 

  • Dr. Yara Onetti Vilalta  Investigadora post-doctoral             yara.onetti@ub.edu

 

  • Victor Arribas Payà   Investigador predoctoral en formació FPU   varribas@ub.edu

Projectes de Recerca

 

  • En actiu

 

2020-2023    Role of TDP-43 in endothelial cells, and its significance in angiogenesis, blood vessel function and vascular homeostasis

                    Agency: Ministerio de Ciencia, Innovación y Universidades

                    Projecte: PID2019-108902GB-I00

                    Funds: 121,000€

                    PI: Dr. Eloi Montañez

 

  • Ajudes finalitzades

 

2016-2020   Role of integrin/parvin-signaling in the neurovascular unit during central nervous system development

                    Agency: German Research Foundation

                    Projecte: MO2562/1-2

                    Funds: 234,050€

                    PI: Dr. Eloi Montañez

 

2012-2016    Functional characterization of parvins on the regulation of endothelial actin cytoskeleton during angiogenesis

                    Agency: German Research Foundation

                    Project: MO2562/1-1

                    Funds: 203,200€

                    PI: Dr. Eloi Montañez

 

Grups amb el que es col·labora
 

  • Prof. Reinhard Fässler. Max Planck Institute of Biochemistry, Germany
  • Prof. Jaap van Buul. University of Amsterdam, Netherlands
  • Prof. Hans-Joachim Schnittler. University of Münster, Germany

Per a més informació sobre les publicacions de l’investigador principal del grup podeu visitar: ORCID: 0000-0003-4059-5056

 

Ramiro-Pareta M, Müller-Sànchez C, Portella-Fortuny R, Soler-Botija C, Torres-Cano A, Esteve-Codina A, Bayés-Genís A, Reina M, X Soriano F, Montanez E, Martinez-Estrada O (2023). Endothelial deletion of Wt1 disrupts coronary angiogenesis and myocardium development. Development. 150(6):dev201147. doi: 10.1242/dev.201147. (Impact factor year of publication: 6.862)

 

Krenn P, Montanez E, Costell M, Werner M, Fässler R (2022). Integrins, anchors and signal transducers of hematopoietic stem cells during development and in adulthood. Current Topics in Developmental Biology. 149:203-261. (Impact factor year of publication: 4.897)

 

Rogg M, Maier JI, van Wymersch C, Helmstädter M, Sammarco A, Lindenmeyer M, Zareba P, Montanez E, Walz G, Werner M, Endlich N, Benzing T Huber TB, Schell C (2022). Alpha-parvin defines a specific integrin adhesome to maintain the glomerular filtration barrier. JASN. 33:786-808. (Impact factor year of publication: 10.12)

 

Onetti Y, Kälin RE, Pitter B, Hou M, Arribas V, Glass R, Montanez E (2022). Deletion of endothelial alpha-parvin inhibits tumour angiogenesis, reduces tumour growth and induces tumour cell apoptosis. Angiogenesis. 25:155-158. (Impact factor year of publication: 9.596)

 

Arts JJ, Mahlandt EK, Grönloh M, Schimmel L, Noorstra I, Gordon E, van Steen A, Tol S, Walzog W, van Rijssel J, Nolte MA, Postma M, Khuon S, Heddleston JM, Wait E, Chew TL, Winter M, Montanez E, Goedhart L, van Buul (2021). Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration. Elife. 3:248-262. (Impact factor year of publication: 7.080)

 

Kälin RE, Cai L, Li Y, Zhao D, Zhang H, Cheng J, Zhang W, Wu Y, Eisenhut K, Janssen P, Schmitt L, Enard W, Michels F, Flüh C, Hou M, Kirchleitner SV, Siller S, Schiemann M, Andrä I, Montanez E et al. (2021). TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression. Cell Syst. 17:248-262. (Impact factor year of publication: 8.673)

 

Werner AC, Weckbach LT, Salvermoser M, Pitter B, Cao J, Maier D, Forné I, Schnittler HJ, Walzog B, Montanez E (2020). Coronin 1B controls endothelial actin dynamics at cell-cell junctions and is required 1 for endothelial network assembly. Front Cell Dev Biol. 708. (Impact factor year of publication: 5.201)

 

Altstätter J, Hess MW, Costell M, Montanez E (2020). α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity. PLoS One. 15(3):e0230380. (Impact factor year of publication: 2.87)

 

Park H, Yamamoto H, Mohn L, Ambühl L, Kanai K, Schmidt I, Kim KP, Fraccaroli A, Feil S, Montanez E, Berger W, Adams RH (2019). Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy. Nat. Commun. 10:5243. (Impact factor year of publication: 12.124)

 

de Juan A, Ince M, Pick R, Chen Ch, Molica F, Zuchtriege G, Wang Ch, Zhang D, Druzd D, Hessenauer M, Pelli G, Kolbe I, Oster H, Prophete C, Hergenhan SM, Albrecht U, Ripperger J, Montanez E et al. (2019). Artery-associated sympathetic innervation drives rhythmic vascular inflammation of arteries and veins. Circulation. 140(13):1100-1114. (Impact factor year of publication: 18.88)

 

Urner S, Planas-Paz L, Hilger LS, Henning C, Branopolski A, Kelly-Goss M, Stanczuk L, Pitter B, Montanez E, Peirce SM, Mäkinen T, Lammert E (2019). Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth. EMBO J. 15:38. (Impact factor year of publication: 10.557)

 

Pitter B, Werner AC and Montanez E (2018). Parvins are required for endothelial cell-cell junctions and cell polarity during embryonic blood vessel formation. Arterioscler Thromb Vasc Biol. 38:1-12. (Impact factor year of publication: 6.607)

 

Cao J, Ehling M, März S, Seebach J, Tarbashevich K, Sixta T, Pitulescu M, Werner A, Flach B, Montanez E, Raz E, Adams RH, Schnittler H (2017). Polarized actin and VE-Cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis. Nat. Commun. 8:1-20. (Impact factor year of publication: 12.124)

 

Pick R, Begandt D, Stocker T, Salvermoser M, Thome S, Böttcher R, Montanez E et al. (2017). Coronin 1A - a novel player in integrin biology - controls neutrophil trafficking in innate immunity. Blood. 130:847-58. (Impact factor year of publication: 13.164)

 

Spuul P, Daubon T, Pitter B, Alonso F, Fremaux I, Kramer I, Montanez E*, Génot E* (2016). VEGF-A/Notch-Induced Podosomes Proteolyse Basement Membrane Collagen-IV during Retinal Sprouting Angiogenesis. Cell Rep.17:484-500. (*) corresponding author (Impact factor year of publication: 8.282)

 

Heemskerk N, Schimmel L, Oort C, Yin T, Ma B, van Unen K, Pitter B, Huveneers S, Goedhart J, Wu Y, Montanez E, Woodfin A, van Buul JD (2016). F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signaling in vivo. Nat. Commun. 7:10493. (Impact factor year of publication: 12.124)

 

 

  •  

Comparteix-ho: