Our laboratory is specialized in the study of the molecular and cell biology of the control of mitochondrial energy metabolism and associated diseases.

We study the molecular mechanisms of transcriptional control of the differentiation of specialized cell types with key roles in energy homeostasis (adipocytes, muscle cells,...) as well as how metabolic and endocrine functions are regulated in cells and tissues. For this purpose, we use experimental models at a sub-cellular (mitochondria), cellular (cell culture) and animal (gene-modified rodent models) levels of analysis.

This is complemented by studying directly samples from patients with metabolic diseases (obesity, lipodystrophy, diabetes,...).

Our aim is to identify the main molecular actors that control energy metabolism in health and disease, and by this means to establish foreseeable prevention and treatment strategies to ameliorate complex metabolic diseases.