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Departament de Bioquímica i Biomedicina Molecular
Facultat de Biologia (UB)

Avda. Diagonal, 645
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08028 Barcelona
Tel 93-4021523 / 606148772

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Thermogenic activation represses autophagy in brown adipose tissue.

Cairó M, Villarroya J, Cereijo R, Campderrós L, Giralt M, Villarroya F

Int J Obes (Lond). 2016 Jun 24.


Brown adipose tissue (BAT) thermogenesis is an adaptive process, essential for energy expenditure and involved in the control of obesity. Obesity is associated with abnormally increased autophagy in white adipose tissue. Autophagy has been proposed as relevant for brown-versus-white adipocyte differentiation; however, its role in the response of BAT to thermogenic activation is unknown.

The effects of thermogenic activation on autophagy in brown adipose tissue were analyzed in vivo by exposing mice to 24 h cold. The effects of norepinephrine, cAMP and modulators of lysosomal activity were determined in differentiated brown adipocytes in primary culture. Transcript expression was quantified by real-time PCR, and specific proteins were determined by immunoblot. Transmission electron microscopy, as well as confocal microscopy analysis after incubation with specific antibodies or reagents coupled to fluorescent emission, were performed in brown adipose tissue and cultured brown adipocytes, respectively.

Autophagy is repressed in association with cold-induced thermogenic activation of BAT in mice. This effect was mimicked by norepinephrine action in brown adipocytes, acting mainly through a cAMP-dependent protein kinase A pathway. Inhibition of autophagy in brown adipocytes leads to an increase in UCP1 protein and uncoupled respiration, suggesting a repressing role for autophagy in relation to the activity of BAT thermogenic machinery. Under basal conditions, brown adipocytes show signs of active lipophagy, which is suppressed by a cAMP-mediated thermogenic stimulus.

Our results show a noradrenergic-mediated inverse relationship between autophagy and thermogenic activity in BAT, and point towards autophagy repression as a component of brown adipocyte adaptive mechanisms to activate thermogenesis.International Journal of Obesity accepted article preview online, 24 June 2016. doi:10.1038/ijo.2016.115.


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Department of Biochemistry and Molecular Biomedicine
Faculty of Biology
University of Barcelona

Our laboratory is specialized in the study of the molecular and cell biology of the control of mitochondrial energy metabolism and associated diseases.

We study the molecular mechanisms of transcriptional control of the differentiation of specialized cell types with key roles in energy homeostasis (adipocytes, muscle cells,...) as well as how metabolic and endocrine functions are regulated in cells and tissues. For this purpose, we use experimental models at a sub-cellular (mitochondria), cellular (cell culture) and animal (gene-modified rodent models) levels of analysis. This is complemented by studying directly samples from patients with metabolic diseases (obesity, lipodystrophy, diabetes,...).

Our aim is to identify the main molecular actors that control energy metabolism in health and disease, and by this means to establish foreseeable prevention and treatment strategies to ameliorate complex metabolic diseases.


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The web page for Adipoplast is available.


Adipoplast.org is the link for the webpage of Adipoplast, a Spanish research network funded by MINECO under coordination by Francesc Villarroya. Eight research groups belong to the network which is focused to the study of adipose tissues and associated pathologies.


Nature Reviews Endocrinology publishes our research on the endocrine role of brown adipose tissue.

Nature Reviews Endocrinology, a leading international journal in the field of endocrinology, publishes the article "Brown adipose tissue as a secretory organ" authored by F. Villarroya, R. Cereijo, J. Villarroya and M. Giralt, which describes the recent research by our groups and others evidencing  an endocrine role for brown adipose tissue. This new concept about the physiological role of brown fat is very relevant to research on the causes of obesity and type II diabetes and the search for new drugs for treatment.


Our group contributes to the "Frontiers in CardioVascular Biology" biennial meeting of the European Society of Cardiology  Council on Basic Cardiovascular Science in  Florence, Italy.

Anna Planavila was chosen to present the study "Involvement of the Fgf21 system in obesity-associated cardiomyopathy", whereas Celia Rupérez presented the poster communication " Cold-induced cardiac hypertrophy is reversed after thermo-neutral deacclimatization".

"Frontiers in Cardiovascular Biology" is considered one of the most relevant exchange platforms for basic and translational cardiovascular biology.

Anna Planavila

Dra. Anna Planavila

Cèlia Rupérez

Celia Rupérez

A study from our laboratory leaded by Aleix Galvadà-Navarro, in collaboration with the J Moreno-Navarrete and JM Fernández-Real at Hospital Josep Trueta in Girona identifies LBP as a negative regulator of browning of adipose tissue. 

Diabetologia, a top rated journal in the field of diabetes and metabolism, publishes this study. The identification of negative regulators of browning in an emerging field with utmost relevance in the identification of novel agents causing obesity and diabetes and potential targets of intervention.

This study is the result of a collaborative task supported by "CIBER Fisiopatología de la Obesidad y Nutrición".

A. Gavaldà 2016

The communication "Alex3, a member of the Armcx family of proteins: a novel actor in the control of energy homeostasis" by Dr Aleix Galvadà-Navarro, awarded as the best poster pitch communication in the European Obesity Summit 2016 held in Gothenburg, Sweden.

The European Obesity Summit 2016 congress, a common initiative of the European Association for the Study of Obesity (EASO) and the International Federation for the Surgery of Obesity (IFSO), was held in Gothenburg between 1 and 4 June 2016.  Dr Tania Quesada was elected for oral presentation of our studies on "Effects of omega-3 PUFA on brown and beige adipocyte differentiation and activation" .Dr Aleix Gavaldà-Navarro presented our studies on the relationship between the Armcx genes and lipotoxicity., a study supported by Fundació la Marató de TV3, in a poster pitch session. His contribution obtained the award to the best communication in basic sciences.

Aleix Gavaldà

Dr. A. Gavaldà

Tania Quesada

Dra. T. Quesada

Our research group participates in the first "Adipose tissue metabolism in obesity" international symposium, organized by the MetNet network in Barcelona.

Prof. Marta Giralt contributed with the presentation "Adipose tissue biology: new insights from the study of adipose-related diseases", and Dr Ruben Cereijo with "A secretory role for brown adipose tissue: Identification of novel brown adipokines"

R. Cereijo


"Targeting brown and beige fat to counteract obesity and the metabolic syndrome", invited presentation from Francesc Villarroya at the 13th International Congress of Obesity in Vancouver.

Francesc Villarroya was invited to present recent research on the discovery and characterization of novel molecules capable of regulating brown and beige adipose activity. The 13th International Congress of Obesity held in Vancouver gathered close to one thousand international researchers in the field of obesity and related metabolic diseases.

Congrés Vancouver

Francesc Villarroya, elected as one of Endocrinology's 2015 Best Reviewer.


Francesc Villarroya has been elected as one of Endocrinology's 2015 Best Reviewers, based on an excellent record of quality reviews and loyal service. The award winners will be acknowledged at the 2016 editorial board meeting. Endocrinology is the major Endocrine Society’s journal since 1917 and has defined the science of endocrinology for most of the twentieth century, being one of the most authoritative biomedical research journals in the world.
Two communications by Marion Peyrou and Ibon Redondo-Angulo, researchers in our lab, awarded for best poster contributions in the 12th Congress of the Spanish Society for the Study of Obesity held in Málaga  25-27th November.

In the picture Marion Peyrou receiving the award from Dr MM Malagón, head of the awards committee.

Anna Planavila awarded by Fundació Marató TV3 for developing a research project on cardiac diseases.
Marató TV3

The project" Role of the new cardiomyokines FGF21 and Metrl in cardiac damage caused by alcoholism and hypertension", leaded by the senior researcher Anna Planavila in our team, has been awarded after selection among the 121 applications to this call. The project will be developed in coordination with Joaquim Fernàndez-Solà, from IDIBAPS.

Researchers received their awards the last November 5th at Acadèmia de Ciències Mèdiques i de la Salut de Catalunya i Balears.

Anna P.
Dra. Anna Planavila
Our research team leads the Spanish  Research Netwrok "Adipose plasticity and associated pathologie" from MINECO.

MINECO has awarded the research network"Adipose plasticity and associated pathologies" in the 2015 call for two year activity.

The network includes research teams from Universidad de Santiago de Compostela, Universidad de Córdoba, Universidad Rey Juan Carlos I de Madrid, Universidad de Navarra,  Hospital Josep Trueta i Universitat Rovira i Virgili, and our team ta UB will act as coordinator.  The network is focused to research on the processes of altered adipose tissue occurring in obesity and lipodystrophy, and the use of adipose tissue as a source for tissue transplantation and isolation of precursor cells for regenerative medicine.

Interview to Francesc Villarroya at El Punt Avui TV in relation to the discovery of FGF21 in breast milk and its beneficial effects on neonates.

Full interview access at:


Our group publishes the results on the presence of FGF21 in breast milk and its beneficial effects on intestinal maturation of newborn.

The work demonstrates that the hormonal factor FGF2 has a key role in the absorption of nutrients and regulating intestine function in newborns, and helps improve neonatal growth and metabolic profile during the first weeks of life. The results of the work have been published in the journal Scientific Reports. This work has been largely a result of the project "FGF21 as a new factor present in milk, involved in the beneficial effects of breastfeeding" awarded three years ago to our research team in the research program RecerCaixa,  Obra Social La Caixa, in collaboration with the Catalan Association of Public Universities (ACUP).

FGF21 is a hormone with anti-obesity and anti-diabetic properties. The research carried out has shown that FGF21 is present in human milk and rodents, and passing the baby through breast milk, acts on the gut, where it stimulates the production of enzymes that promote absorption lactose and other gastrointestinal hormones that help absorb nutrients properly.


After these results, we are currentlyt investigating the long-term effects effects on metabolism of having been exposed to FGF21 from milk and if this factor is present and in what percentage in formula milk, with the support of a project recentlyawarded to our lab by Instituto Danone.

Research cooperation with UADEC, Mexico

The "Departamento de Inmunología Molecular del Centro de Investigación Biomédica de la Facultad de Medicina de la Universidad Autónoma de Coahuila, México", represented by Dr Francisco Carlos López Márquez, signed an agreement for research cooperation with our research team for studies on metabolic and immunologic alterations in HIV patients.

Francesc Villarroya receives the ICREA Academia award 2014

On Wednesday July 1, the auditorium Pau Gil at the modernist Hospital de Sant Pau area hosted the ceremony for the ICREA Academia 2014, a call which has distinguished scientific career of researchers from Catalan universities. The event, attended by the rector of UB, Dr. Dídac Ramírez, was chaired by the Minister of Economy and Knowledge, Dr. Andreu Mas-Colell, Secretary of Universities and Research, Dr. Antoni Castellà, and the director of  ICREA, Dr. Jaume Bertranpetit.


Interpol warns of threatening illegal slimming drug DNP. The dangers of uncontrolled mitochondrial uncoupling commented by Francesc Villarroya in "El País"


Francesc Villarroya comments in "El País" (5 May issue) the mechanisms of action of dinitrophenol as a mitochondrial uncoupler and the dangers of using it as slimming drug to promote energy expenditure. The recent death of an English obese patient due to DNP consumption highlights this concern.


Tania Quesada, fellow in our laboratory,  participates in the "Jornadas Catalunya-Mexico" organized by CONACYT with the support of the Consulate of Mexico in Barcelona and Universitat Politècnica de Catalunya the 4-5 of July

Catalonia has traditionally been a center of academic attraction for Mexican students. In 2014-2015 academic year there are about 400 students with scholarships from the National Council of Science and Technology of Mexico (CONACYT) to continue graduate studies, doctoral and postdoctoral fellowships in various Catalan institutions. In order to promote scientific cooperation between them, a meeting has been organized by CONACYT with the support of the Consulate of Mexico in Barcelona and Catalan Universities.


Tania Quesada, fellow in our research group, participated in the meeting and was selected for the "Tesis en 3 minutos" contest and for a report of her research in our lab appeared as press release in "CONACYT agencia de noticias".




See http://www.conacytprensa.mx/index.php/ciencia/salud/1785-estudian-hormona-que-ayuda-adelgazar for further information.

Our research team contributes to the Handbook of Experimental Pharmacology series with the chapter "Adipokines and the endocrine role of adipose tissues"



Tania Quesada, PhD student in our lab, awarded for the best poster presentation in the 22nd European Congress of Obesity (ECO 2015) in Prague.

Our research team participated to the ECO 2015 meeting in Prague with an invited presentation by Francesc Villarroya on novel myokines, an oral presentation by Anna Planavila on heart damage caused by high fat diets and poster presentations by Tania Quesada on FGF21 action in adipose tissues and by José M. Gallego-Escuredo on ageing adipose tissue.  Tania Quesada was awarded for the communication “Effects of FGF21 invalidation on brown and white adipose tissue pathophysiology“ presented in a poster pitch session.


Our identification of the role of FGF21 in cardiac oxidative stress, in the cover of the April issue of Cardiovascular Research.

Under the title "Cardiac Fgf21 synthesis and release: an autocrine loop for boosting up antioxidant defenses in failing hearts", Cardiovascular Research, a highly reputed journal in the field of cardiac research, includes an extensive Editorial summarizing our findings on the role of FGF21 in cardiac protection  on occasion of our publication "FGF21 protects the heart from oxidative stress" in the April issue of the journal. In the cover of the journal, a pictorial description of our findings on FGF21 action on heart is provided.
Our research team contribute to dissemination of recent research on the role of brown adipose tissue activity on obesity prevention and treatment in “El Periódico”   

The March 3rd issue of “El Periódico” summarizes the current views on brown adipose tissue activity in relation to obesity and comments by Francesc Villarroya.


Full text can be viewed at:



Francesc Villarroya, awarded with the 2015 ICREA Academia Award by the Institució Catalana de Recerca i Estudis Avançats (ICREA)




The ICREA Academia Awards are given for a period of five years in recognition of the scientific trajectory of university professors. Awardees receive funds over this period to support their lines of research,e ICRE teaching activities and allow awardees to concentrate on research.
The BBVA Foundation funds the research project “Involvement of the Fgf21 System in Obesity-Related Heart Disease” coordinated by Francesc Villarroya and Anna Planavila.

The main objective of the call was to increase individual and collective research opportunities in Spain in order to encourage scientific activity in biomedicine (oncology, cardiology, neurodegenerative diseases, etc.), digital humanities, ecology and conservation biology and social and economic sciences. 589 projects competed for the six BBVA Foundation Grants for Research Projects in Biomedicine 2014. The project, based on the study of the heart damage as a consequence of obesity, will be developed in the next 3 years.


Francesc Villarroya has received one of the two research grants awarded by the Danone Institute in the fields of food, nutrition and health.


Our team will receive funds to develop the project “FGF21, a new bioactive factor of breast milk”. The award ceremony took place on Thursday 18 December at the Royal Academy of Medicine, in Madrid.

The personalities who participate in the event were Teresa Robledo de Dios, adviser of the Spanish Strategy for Nutrition, Physical Activity and Prevention of Obesity of the Spanish Agency of Consumption, Food Security and Nutrition; Joaquín Poch, president of the Royal Academy of Medicine; Manuel Serrano, honorary president of the Danone Institute; Luis A. Moreno, president of the Danone Institute, and Joao Paulo Andorinha, R&D director of Danone.





Aleix Gavaldà, awarded for best communication at the symposium "Obesity and Nutrition in the 21st Century"

The communication "Lipopolysaccharide binding protein-null mice are protected against obesity but show altered glucose homeostasis" by our research group, with Aleix Gavladà as first autor, got one of the five awards to best communications in the symposium organized by CIBERobn at El Escorial, Madrid.

The study was based on the development and characterization of a mouse model to determine the role of LBP protein in adiposity and metabolism. This study was developed in collaboration with the research team leaded by JM Fernández Real, from Hospital Josep Trueta, Girona.


Our research on heart, in the cover of "Heart and Metabolism"


Anna Planavila and Francesc Villarroya, in collaboration with Manlio Vinciguerra,  contribute to the  July issue of of the journal Heart & Metabolism , devoted to "Diet and the heart", with the article ."Nutrient signaling and cardiovascular ageing". Heart and Metabolism is a quarterly journal focusing on the management of cardiovascular diseases. Its aim is to inform cardiologists and other specialists about the newest findings on the role of metabolism in cardiac disease and to create awareness of their potential clinical implications.The cover of the issue includes a picture of cardiomyocytes, corresponding to our research on cardiac hypertrophy.


For more information




Ibon Redondo, PhD fellow in our lab, selected and awarded to present his data on “Involvement of fibroblast growth factor-21 in gestation-induced cardiac hypertrophy “ in the ESC Congress 2014 in Barcelona, Spain

The European Socieity of Cardiology Congress, with over 30.300 delegates, held in Barcelona in September 2014, has been one of the biggest and most exciting in the history of the ESC society. The study “Involvement of fibroblast growth factor-21 in gestation-induced cardiac hypertrophy “, developed in our lab by Ibon Redondo under the direction of Anna Planavila and Francesc Villarroya,  was selected for presentation in order to communicate the recent results of our research group on the regulatory role of FGF21 on cardiac function.
Ibon Redondo was also awarded with an ESC fellowships to the best communications.  The study highlights the importance of cardiac function in pregnancy and the role of regulatory factors for healthy adaptations of heart to gestation.


Ricardo Moure, pre-doc researcher in our lab, winner of FameLab Spain with a monologue about obesity and diabetes.


Ricardo Moure , a pre-doc researcher in our lab, has been announced as winner of FameLab Spain in the final which took place on May 14 , in Madrid.

FameLab is an international scientific talks competition which started up in 2005 from an original idea at Cheltenham Science Festival, with the main purpose of nurturing the communication of science by identifying, training and introducing new talents - new spokespeople working in science - with an innovative format: short scientific talks.

Ricardo Moure made a three-minute monologue about the effects of the fat in our body when we have obesity and how it favors type II diabetes. With this victory,  Ricardo has secured participation in the international final of the Cheltenham Festival, to be held from 3rd to 8th of June.

Good luck, Ricardo!


Dissemination of recent research on the role of  human brown adipose tissue activity in the biology of the endocrine factors FGF21 and irisin in “The Conversation”





Following the publication in Cell Metabolism of a recent paper by F.Celi about shivering, FGF21 and irisin (http://www.cell.com/cell-metabolism/abstract/S1550-4131%2814%2900006-0)  and the recent paper from our group in Metabolism on FGF21 expression in human brown fat (http://www.ncbi.nlm.nih.gov/pubmed/24369918),  Francesc Villarroya publishes the report “Shivering unlocks new way of fighting fat"  in The Conversation, an international on-line journal devoted to public dissemination of scientific findings (https://theconversation.com/shivering-unlocks-new-way-of-fighting-fat-22662).

Our research team has been awarded by Fundació Marató TV3 for developing the project “ Lipotoxicity, hepatic steatosis and hepatocarcinoma: function of the mitochondrial protein family armc10/armcx”, in coordination with the Department of Cell Biology of UB and the Institut de Recerca Vall d’Hebron.



The project was one of the 42 projects awarded among the 318 projects apllying for support to the 2012 " Fundació Marató de TV3" call for research on cancer. The project will be developed during the following three years, and will explore the role of  the mitochondrial proteins armc10/armcx in herpatocarcinoma and the involvment of lipid metabolism alterations. The principal investigators of the projects received the awards at PRBB auditorium , last November 12th.

Our laboratory participates in the EASD meeting in Barcelona



Francesc Villarroya presentation ”Brown adipose tissue, a sink of glucose disposal? Effects of FGF21 on glucose metabolism in brown adipose cells” (address for webcast presentation: http://www.easdvirtualmeeting.org/resources/5945) and the poster communications “Alterations in the levels of endocrine factors FGF21 and FGF19, and in the expression of their receptors, are associated with impaired glucose homeostasis in obese patients” and “Involvement of the endocrine factor FGF21 in the beneficial effects of dietary long-chain n-3 polyunsaturated fatty acids” presented by José Miguel Gallego-Escuredo and Joan Villarroya, respectively, showed recent data from our lab to this major international scientific event concerning diabetes research and treatment.

The publication “White, brown, beige/brite: different adipose cells for different functions?” selected as “Editor’s choice” in the September 2013 issue of Endocrinology.



The paper “White, brown, beige/brite: different adipose cells for different functions?” (http://www.ncbi.nlm.nih.gov/pubmed/23782940) by Marta Giralt and Francesc Villarroya has been selected as “Editor’s choice” in the September 2013 issue of Endocrinology, a leading journal of the USA Endocrine Society.

Our publication “An endocrine role for brown adipose tissue?”, “Featured Article” in the journal American Journal of Physiology-Endocrinology and Metabolism.


Our paper “An endocrine role for brown adipose tissue?”, (http://www.ncbi.nlm.nih.gov/pubmed/23839524) published in July 2013 in the “Perspectives” series of the American Journal of Physiology-Endocrinology and Metabolism, has been chosen as “Featured Article”. This paper discusses the current evidence that brown adipose tissue, in addition with its known role in energy expenditure, could also behave as an endocrine organ and release regulatory factors, the so-called “batokines”. The American Journal of Physiology is the leading journal of the  125th-year-old American Physiological Society.



The discovery of a cardioprotective acion of FGF21 by our research group, published in Nature Communications




The European Foundation for the Study of Diabetes funds a project led by our research group

Our research team is the only Spanish lab  that will receive funds from the programme fostered by the European Foundation for the Study of Diabetes (EFSD) and the pharmaceutical firm Nova Nordisk in 2013.

Funds will be employed in a research project for the Identification of novel endocrine factors secreted by brown fat (batokines) with anti-diabetic action. Within the project, which will be carried out between 2013 and 2015, our group will use some experimental protocols for laboratory animals to study the role of brown fat —primary organ responsible for generating heat— in endocrine functions; in other words, the study of how brown fat secretes a series of factors involved in signalling pathways of lipid metabolism and glucose homeostasis.

The objective of the project is to study and identify the role of batokines —factors secreted by brown fat — in lipid metabolism, blood glucose control and the processes related to molecular inflammatory mechanisms. In the future, the research might contribute to provide new treatments for diseases such as obesity and diabetes, two major threats to global public health that are rapidly getting worse in most developed countries.


The review "Beyond the sympathetic tone: the new brown fat activators" by F.Villarroya and A.Vidal-Puig, published in the May issue of the journal Cell Metabolism.




Our research team, awarded with one of the 2012 grants from Recercaixa



“La Caixa” and Associació Catalana d’Universitats Públiques (ACUP) are the promoters of Programa RecerCaixa.  The call for ReserCaixa grants awards every year the best research projects from Catalan research teams. In 2012, 369 projects applied, among which 25 were finally awarded. Our research project on FGF21 and development got one of the awards providing funding for a two-year research period in this area. In the picture, the director of Recercaixa and Dr Villarroya in the act of awards in CosmoCaixa in February 2013.




ESE News, the newsletter journal of the European Society of Endocrinologist features the article "Turning brown to be healthy" by Francesc Villarroya, in co-authorship with Antonio Vidal-Puig.


The autumn 2012 issue of the jorunal includes the article summarizing the emerging concepts on the role of brown adipose tissue in energy expenditure and the recently discovered molecules (FGF21, Bmp8b, irisin,...) controlling its activity.

For full access to the article

Our research group participates in the discovery of a new mechanism of regulation of brown adipose tissue, as published in the May issue of  Cell.


The Bone morphogenetic protein B (BMP8B) plays a key role in the regulation of thermogenesis in brown adipose tissue, according to the conclusions, acting at both central and peripheral level. The finding was the result of investigations conducted by the research group of Antonio Vidal-Puig, University of Cambridge, UK, with the participation of laboratories from Iowa (USA), Stockholm (Sweden) and Santiago de Compostela. In this collaborative research, our group provided, among other contributions, key  information on the role of PPARalfa in the control of the Bmp8b gene.

For more information see:




Biochemical Journal comments our recent paper “Pref-1 in brown adipose tissue; specific involvement of in brown adipocyte differentiation and regulatory role of C/EBPdelta” by Jordi Armengol and collaborators.

Under the title “Pref-1 preferentially inhibits heat production in brown adipose tissue”, Eric Kalkhoven and collaborators from the University Medical Centre Utrecht comment our recent publication in Biochemical Journal (Armengol J et al. Biochem J. 2012 May 1; 443(3):799-810), our findings indicating a repressive role of Pref-1 in brown fat thermogenesis and the evidence that specific manipulation of brown adipose tissue may open up new therapeutic ways to combat obesity-associated health problems.




Our publication  "Peroxisome Proliferator-activated Receptor-gamma Coactivator-alpha Controls Transcription of the Sirt3 Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype”  in the Journal of Biological Chemistry  has been designated as one of the best papers published by the journal in 2011.


The journal selected only 20 papers – out of the more than 4,000 that were published last year – to receive this special designation. They chose one paper for each of the jounral’s affinity groups, and the study by Giralt and collaborators represents the best in the Bioenergetics affinity group.

Journal of Biological Chemistry will make a public announcement soon, and have made all of the Best of 2011 papers freely accessible at http://www.jbc.org/site/bestoftheyear.

The Journal of Biological Chemistry is the official journal of the American Society for Biochemistry and Molecular Biology (ASBBM), established in 1905,  it is among the international journals on Biochemistry with the highest international reputation.  

A preview on the role of irisin in white-to-brown adipose transformation in the March 7th issue of Cell Metabolism.


Francesc Villarroya reviews and discusses the recent identification of irisin, a novel myokine, on the "browning" of white fat, the process by which brown adipocytes develop inside white adipose tissue depots.

Francesc Villarroya contributes to the dissemination of recent research on the control of brown adipose tissue activity and its relevance in obesity.




On February 2nd, 2012,  Francesc Villarroya has been interviewed in Telediario, the major news program in Spanish TV, to explain the significance of recent findings on the control of brown fat activity and novel agents stimulating brown fat thermogenesis in relation to energy balance and obesity.

"A report and interview with Francesc Villarroya in the Newsletter of CIBERobn"


A report in the newspaper "El País" summarizes the current advancements in brown adipose tissue research in relation to obesity and quote the opinions of F Villarroya among other experts.



Our research group is contributing to scientific spreading: “Brown fat and Obesity” in the April issue of “Investigación y Ciencia”, the Spanish version of Scientific American.

  In the section “`Panorama”, Francesc Villarroya, Roser Iglesias and Marta Giralt summarize the recent evidence of the importance of brown fat in adult humans and its role in energy expenditure and the control of obesity.


Full Article


A novel contribution of our research team on the role of brown adipose tissue in FGF21 biology, published in Journal of Biological Chemistry

We report that brown adipose tissue is not only a target but also a source of the hormonal factor FGF21 after activation of thermogenesis. This discovery may be the tip of the iceberg of the recognition of a novel endocrine role of brown fat as source of regulatory molecules with impact in overall metabolism.

The paper is already available on-line at http://www.ncbi.nlm.nih.gov/pubmed/21317437

The Figure at the end of the study summarizes the major findings.

The December 2010 issue of the journal Current Pharmaceutical Design, with the title "Targets of Metabolic Toxicity of HIV Antiretroviral Drugs: The Multiple Roads to Lipodystrophy and Metabolic Syndrome", has been edited by our research team in collaboration with P. Domingo.


The December issue of Current Pharmaceutical Design has been devoted to "Targets of Metabolic Toxicity of HIV Antiretroviral Drugs: The Multiple Roads to Lipodystrophy and Metabolic Syndrome".  Francesc Villarroya, in collaboration with Pere Domingo, acted as executive guest editor of this issue. The issue includes several review articles on the distinct aspects of the ethiopathogenesis of lipodystrophy syndrome and the metabolic alterations appearing in HIV-1-infected patients under antiretroviral treatment. Adipose cell alterations, inflammation, lipotoxicity and pharmacogenomics of the syndrome are among the subjects covered. The most recognized international experts in the field have participated in the issue. The cover of the journal depicts the lipotoxic events associated with these metabolic alterations in HIV-1 patients.



The XI International Congress on Obesity rewards a research work of our team


The XI International Congress on Obesity, held in Stockholm, has distinguished the communication “ FGF21, a novel actor in the control of brown adipose tissue activation Thermogenics” presented by our team as one of the top five communications.

This communication was selected among 1,250 worldwide research projects. Specifically, it has been considered the best communication in the field of Experimental Medicine and Physiology (one of the five areas of research in the Congress).

An article on the discovery of a new pathway of thermogenesis hormonal control, carried out by our research team,  on “Cell Metabolism” cover.


The publication, edited on “ Cell Metabolism” March issue, identifies the hormonal  factor FGF21 as a new activator of brown adipose tissue and its metabolic consumption activity. FGF21 is produced by the liver that releases it into the circulation in response to the stimulation of fatty acids. The study, based on the use of neonatal mice as an experimental model which are exposed to milk fat for the first time in their development, identifies a new pathway of controlling the energy expenditure with potential therapeutic application in obesity and type II diabetes.

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