Project:

This proposal aims to identify and characterise 5 NPS (psychostimulants and psychedelics) that pose a high risk to health and for which there is not enough information available.

To achieve this goal:

-A list of newly emerging NPS will be created.

-Among them, the PREDICT-NPS software will identify those NPS with the highest cardiotoxic, abuse and/or psychedelic potential, from which 5 will be selected according to scientific-technical criteria.

-After their synthesis.

-The mechanism of action will be characterised and.

-The psychostimulant, hallucinogenic and reward properties will be studied in male and female mice.

-An alternative method, zebrafish larvae, will be used to study cardiotoxicity.

Finally, scientific reports will be generated with data on their cardiotoxic, psychedelic and/or addictive potential, useful information for their analytical detection, as well as recommendations regarding their health risks. These reports will be immediately transferred to the Spanish.

Early Warning System and the National Plan on Drugs (PNsD), as well as to international organisations, such as the European Monitoring.

Centre for Drugs and Drug Addiction (EMCDDA), involved in drug alerts and monitoring, which can use this information to promote specific drug policies. For this reason, the EMCDDA acts as EPO of this project.