Neuroquímica. IP: Manuel J. Rodríguez Allué

Manuel J Rodríguez Allué
PhD, Profesor agregado
marodriguez@ub.edu

Gisela Besa Selva
Estudiante de doctorado
giselabesa@ub.edu

Alba Ramón Lainez
Estudiante de doctorado
ramon-lainez@ub.edu

Carmen Andrade López
Técnico de laboratorio
candrade@ub.edu

Violeta Fàbregas Velázquez
Estudiante de grado
vfabreve23@alumnes.ub.edu

Daniela Ruíz Camacho
Estudiante de grado
druizcam7@alumnes.ub.edu

• Estudio de la función de la proteína VPS13A en los mecanismos de plasticidad sináptica en las neuronas de los ganglios basales y su relevancia en los trastornos del movimiento.
• Papel de la microglia en los procesos de disfunción sináptica presentes en la enfermedad de Huntington.

• Identificar los mecanismos convergentes activados por la huntingtina mutada y la falta de VPS13A responsables de la neurodegeneración selectiva de las neuronas estriatales

IP: Jordi Alberch y Manuel J Rodríguez Allué
Ministerio de Ciencia, Innovación y Universidades
2021-2024

• Non-invasive dynamic neural control by laser-based technology

IP: Mercè Masana Nadal
European Union
NEUROPA (www.neuropaproject.com)
2020 -2022

• Training European teachers to integrate health in the school day

IP: Manuel J. Rodríguez Allué
EIT-Health
Schools@once
2021

• Identification of chorein function in neurodegeneration of the basal ganglia for developing new therapeutical approaches in Chorea-Acanthocytosis

IP: Jordi Alberch Vie, Manuel J Rodríguez Allué y Mercè Masana Nadal
Fundació ChAC
FBG309965
2018-2021

• Modulación de la dinámica de las redes neuronales como estrategia terapéutica para recuperar la disfunción de los ganglios basales en las enfermedades del movimiento

IP: Jordi Alberch Vie y Manuel J Rodríguez Allué
MINECO
SAF2017-88076-R
2018- 2020

Para más información sobre las publicaciones del IP del grupo pueden visitar el siguiente enlace:
ORCID: https://orcid.org/0000-0002-4476-004X
ResearcherID: http://www.researcherid.com/rid/L-2212-2014

Sancho-Balsells A, Borràs-Pernas S, Flotta F, Chen W, Del Toro D, Rodríguez MJ, Alberch J, Blivet G, Touchon J, Xifró X, Giralt A. Brain-gut photobiomodulation restores cognitive alterations in chronically stressed mice through the regulation of Sirt1 and neuroinflammation. J Affect Disord. 2024 Jun 1:354: 574-588. doi: 10.1016/ j.jad.2024.03.075. Epub 2024 Mar 14. PMID: 38490587

Rodríguez-Urgellés E, Casas-Torremocha D, Sancho-Balsells A, Ballasch I, García-García E, Miquel-Rio L, Manasanch A, Del Castillo I, Chen W, Pupak A, Brito V, Tornero D, Rodríguez MJ, Bortolozzi A, Sanchez-Vives MV, Giralt A, Alberch J. Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington's Disease. Cell Mol Life Sci. 2023 Nov 21;80(12):367. doi: 10.1007/s00018-023-05015-. PMID: 37987826

García-García E, Ramón-Lainez A, Conde-Berriozabal S, Del Toro D, Escaramis G, Giralt A, Masana M, Alberch J, Rodríguez MJ. VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis. Neurobiol Dis. 2023 Oct 15:187: 106292. doi: 10.1016/ j.nbd.2023.106292. Epub 2023 Sep 13. PMID: 37714309

Muñoz-Violant S, Violant-Holz V, Rodríguez MJ. Factors of well-being of youth with complex medical conditions from the experience of hospitalization and convalescence: A pilot study. PLoS One. 2023 May 4;18(5): e0285213. doi: 10.1371/ journal.pone.0285213. eCollection 2023 PMID: 37141278

Conde-Berriozabal S, García-Gilabert L, García-García E, Sitjà-Roqueta L, López-Gil X, Muñoz-Moreno E, Boutagouga Boudjadja M, Soria G, Rodríguez MJ, Alberch J, Masana M. M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus. J Neurosci. 2023 May 3;43(18): 3379-3390. doi: 10.1523/ JNEUROSCI.1172-22.2023. Epub 2023 Mar 31. PMID: 37001992

Violant-Holz V, Rodríguez-Silva C, Rodríguez MJ. Preschool teachers display a flexible pattern of pedagogical actions in promoting healthy habits in children. Front Psychol. 2023 Apr 24:14: 1172460. doi: 10.3389/ fpsyg.2023.1172460. eCollection 2023. PMID: 37168422

Ballasch I, García-García E, Vila C, Pérez-González A, Sancho-Balsells A, Fernández J, Soto D, Puigdellívol M, Gasull X, Alberch J, Rodríguez MJ, Canals JM, Giralt A. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Brain Behav Immun. 2023 Mar:109:144-161. doi: 10.1016/j.bbi.2023.01.016. Epub 2023 Jan 23. PMID: 36702234

Sancho-Balsells A, García-García E, Flotta F, Chen W, Alberch J, Rodríguez MJ, Avila C, Giralt A. Meridianins Inhibit GSK3β In Vivo and Improve Behavioral Alterations Induced by Chronic Stress. Mar Drugs. 2022 Oct 19;20(10): 648. doi: 10.3390/ md20100648. PMID: 36286471

Garcia-Garcia E, Chaparro-Cabanillas N, Coll-Manzano A, Carreras-Caballé M, Giralt A, Del Toro D, Alberch J, Masana M, Rodríguez MJ. Unraveling the spatiotemporal distribution of VPS13A in the mouse brain. Int J Mol Sci 2021 Dec 1;22(23): 13018. doi: 10.3390/ ijms222313018 PMID: 34884823

Muñoz-Violant S, Violant-Holz V, Gallego-Jiménez MG, Anguera MT, Rodríguez MJ. Coping strategies patterns to buffer the psychological impact of the State of Emergency in Spain during the COVID-19 pandemic’s early months. Sci Rep 2021 Dec 22;11(1): 24400. doi: 10.1038/ s41598-021-03749-z PMID: 34937863.

Violant-Holz V, Rodríguez-Silva C, Carol M, Rodríguez MJ. Impact of cocreation training capsules for preschool teachers on children’s healthy habits: a pilot study conducted in Barcelona, Spain. BMC Public Health 2021 Nov 14;21(1):2089. doi: 10.1186/ s12889- 021- 12160-2 PMID: 34774028

Ding K, Yang J, Chin MK, Sullivan L, Durstine JL, Violant-Holz V, Demirhan G, Oliveira NRC, Popeska B, Kuan G, Khan W, Dai J, Xu X, Mladenova Z, Balasekaran G, Smith GA, on behalf of Global Community Health-Covid-Collaborative Research Team. Physical Activity among Adults Residing in 11 Countries during the COVID-19 Pandemic Lockdown. Int J Environ Res Public Health 2021 Jul 1;18(13):7056. doi: 10.3390/ ijerph18137056. PMID: 34280992

Masana M, Rodríguez MJ, Alberch J. Proceedings of the tenth international meeting on neuroacanthocytosis syndromes. Tremor Other Hyperkinet Mov (NY) 2021 May 21;11:19. doi: 10.5334/tohm.622. PMID: 34046249

Pérez-Sisqués L, Martín-Flores N, Masana M, Solana-Balaguer J, Llobet A, Romaní-Aumedes J, Canal M, Campoy-Campos G, García-García E, Sánchez-Fernández N, Fernández-García S, Gilbert JP, Rodríguez MJ, Man HY, Feinstein E, Williamson DL, Soto D, Gasull X, Alberch J, Malagelada C. RTP801 regulates motor cortex synaptic transmission and learning. (2021) Exp Neurol 342:113755. PMID: 33984337

Ding K, Yang J, Chin M, Sullivan L, Demirhan G, Violant-Holz V, Uvinha RR, Dai J, Xu X, Popeska B, Mladenova Z, Khan W, Kuan G, Balasekaran G, Smith GA on behalf of Global Community Health–COVID-19 Collaborative Research Team. Mental health among adults during the COVID-19 pandemic lockdown: A cross-sectional multi-country comparison. (2021). Int J Environ Res Public Health 18: 2686. PMID: 33800008

Violant-Holz V, Gallego-Jiménez MG, González-González CS, Muñoz-Violant S, Rodríguez MJ, Sansano-Nadal O, Guerra-Balic M. Psychological health and physical activity levels during the COVID-19 pandemic. A systematic review. (2020) Int J Environ Res Public Health 17: 9419. PMID: 33334073

Kim A, García-García E, Straccia M, Comella-Bolla A, Miguez A, Masana M, Alberch J, Canals JM, Rodríguez MJ. Reduced fractalkine levels lead to striatal synaptic plasticity deficits in Huntington's disease. Front Cell Neurosci. Jun 18;14:163. doi: 10.3389/ fncel.2020.00163. eCollection (2020). IF: 3,921. PMID: 32625064

Fernández-García S, Orlandi JG, García-Díaz Barriga GA, Rodríguez MJ, Masana M, Soriano J, Alberch J. Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington's disease. BMC Biology 18:58. BMC Biol 18:58 (2020). https://doi.org/10.1186/s12915-020-00794-4 (2020). IF: 6,723. PMID 32466798

Fernández-García S, Conde-Berriozabal S, García-García E Gort-Paniello C, Bernal-Casas D, García-Díaz Barriga G, López-Gil J, Muñoz-Moreno E, Sòria G, Campa L, Artigas , Rodriguez, MJ, Alberch J, Masana M. M2 Cortex-Dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington’s Disease. doi: 10.7554/eLife.57017 (2020). IF: 6,830. PMID: 33016873

Vidal-Taboada JM, Pugliese M, Salvadó M, Gámez J, Mahy N, Rodríguez MJ. (2018). KATP Channel Expression and Genetic Polymorphisms Associated with Progression and Survival in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2018 Oct; 55(10): 7962-7972. doi: 10.1007/ s12035-018-0970-7. Epub 2018 Feb 28. IF: 4,586. PMID: 29492846

Rodriguez MJ, Mahy N. Neuron-microglia interactions in motor neuron degeneration. The inflammatory hypothesis in amyotrophic lateral sclerosis revisited. (2016) Curr Med Chem 23:4753-4772. IF: 3,249. PMID: 27881068

Martinez-Moreno M, Vidal-Taboada JM, Ortega FJ, Batlle M,  Mahy N, Rodriguez MJ. Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus” (2016) Neurosciece 333:229-243. IF: 3,277. doi: 10.1016/j.neuroscience.2016.07.032. Epub 2016 Jul 25. PMID: 27471195

Espinosa-Parrilla J, Pugliese M, Mahy N, Rodríguez MJ. Neuroprotection: A new therapeutic approach of relapsing remitting multiple sclerosis, cap 13 en Trending topics in Multiple sclerosis; p. 307-328. Ed. González-Quevedo A. (2016) InTech, Rijeka. ISBN 978-953-51-4678-0

Vidal-Taboada JM, López-López A, Salvado M, Lorenzo L, García C, Mahy N, Rodriguez MJ, Gámez J. UNC13A confers risk for sporadic ALS and influences survival in a Spanish cohort. J Neurol. 2015 Oct; 262(10): 2285-92. doi: 10.1007/ s00415-015-7843-z. Epub 2015 Jul 11. PMID: 26162714, IF: 3,408

Batlle M, Ferri L, Andrade C, Ortega J, Vidal-Taboada JM, Pugliese M, Mahy N, and Rodríguez MJ. Astroglia-microglia crosstalk during neurodegeneration in the rat hippocampus. Biomed Res Int. 2015; 2015: 102419. doi: 10.1155/ 2015/102419. Epub 2015 Apr 21. PMID: 25977914. IF: 2,134

Espinosa-Parrilla JF, Martínez-Moreno M, Gasull X, Mahy N, and Rodríguez MJ. The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity. Mol Cell Neurosci. 2015 Jan;64: 104-15. doi: 10.1016/ j.mcn.2014.12. 004. Epub 2014 Dec 12. PMID: 25497271. IF: 3.597

Bosch MN, Pugliese M, Andrade C, Gimeno-Bayón J, Mahy N, and Rodríguez MJ. Aβ immunotherapy reduces amyloid plaques and astroglial reaction in aged domestic dogs. Neurodegener Dis. 2015; 15(1): 24-37. doi: 10.1159/ 000368672. Epub 2014 Dec 20. PMID: 25531153. IF: 2.937

Virgili N, Mancera P, Chanvillard C, Wegner A, Wappenhans B, Rodríguez MJ, Infante-Duarte C,  Espinosa-Parrilla JF, Pugliese M. Diazoxide attenuates autoimmune encephalomyelitis and modulates lymphocyte proliferation and dendritic cell functionality. J Neuroimmune Pharmacol. 2014 Sep; 9(4): 558-68. doi: 10.1007/ s11481-014- 9551-3. Epub 2014 Jun 18. PMID: 24939091. IF: 4,110

López-López A, Gámez J, Syriani E, Morales M, Salvado M, Rodríguez MJ, Mahy N, and Vidal-Taboada JM. CX3CR is a modifying gene of survival and progression in Amyotrophic Lateral Sclerosis. PLoS One. 2014; 9(5): e96528. Published online 2014 May 7. doi: 10.1371/ journal.pone.0096528. PMID: 4013026. IF: 3,234

Gimeno-Bayón J, López-López A, Rodríguez MJ, and Mahy N. Glucose pathways adaptation supports acquisition of activated microglia phenotype. J Neurosci Res. 2014 Jun; 92(6): 723-31. doi: 10.1002/ jnr.23356. Epub 2014 Feb 7. PMID: 24510633. IF: 2,594

Ortega FJ, Vukovic J, Rodríguez MJ, and Bartlett PF. Blockade of microglial KATP-channel abrogates suppression of inflammatory-mediated inhibition of neural precursor cells. Glia. 2014 Feb; 62(2): 247-58. doi: 10.1002/ glia.22603. Epub 2013 Dec 6. PMID: 24311472. IF: 6,031

• Ofertas de la Universidad de Barcelona:

Trabajo UB

• Ofertas del grupo de investigación:

Por el momento, no hay ofertas de trabajo de este grupo de investigación