Section of Therapeutic Chemistry

Organic Chemistry Unit

Pérez-García, Ma. Lluïsa

Supramolecular systems in Nanomedicine


Research Lines

- Supramolecular chemistry

- Template synthesis and self-assembly in organic synthesis

- Mechanically interlocked compounds: catenanes and rotaxanes

- Molecular machines and switches

- Nanobiosensors for pharmaceutical applications

- Anionophores based on amphiphilic imidazolium salts

- Functionalisation of micronanotools for tagging and actuate in living cells

- Nanoparticles for drug delivery

- Porphyrins for photodynamic therapy

Areas of Experience

- Organic Chemistry

- Supramolecular Chemistry

- Therapeutical Chemistry

- Nanochemistry

Research Projects

Title of the project: Bio-Functionalization of micronanotools to study, tag and actuate inside living cells

Financing administration: MICINN (Spanish Ministry of Science and Innovation)

Keywords: Functionalization / micro/nanoprinting / Adhesion / Cell


Title of the project: Chirality on surfaces and molecular machines

Kind of Program: Ajuts de Suport als Grups de Recerca de Catalunya (SGR)

Financing administration: Generalitat de Catalunya AGAUR

Keywords: Stereochemistry / nanoscience / rotors


Publications from the last three years

Novel Anionophores for Biosensor applications: Nano Characterisation of SAMs based on amphiphilic Imidazolium Protophanes and Cyclophanes on Gold Surfaces

Sporer, C.; Casal Dujat des Allimes, L.; Caballero, D.; Errachid, A.; Samitier, J.; Pérez-García, L.

Sensor Lett., 2009, 757-764

Proton ionizable 1H-1,2,4-triazole p-electron deficient cyclophanes as hosts and in [2]catenanes

Ramos, S.; Alcalde, E.; Stoddart, J. F.; White, A. J. P.; Williams, D. J.; Pérez?García, L.

New J. Chem., 2009, 33, 300-317

Topology in molecules inspired, seen and represented

Pérez-García, L.; Amabilino, D.

Chem. Soc. Rev., 2009, 38, 1562-1571

Towards a Tunable Tautomeric Switch in Azobenzene Biomimetics: Implications for the Binding Affinity of 2-(4’-Hydroxyphenylazo)Benzoic Acid (HABA) to Streptavidin

Farrera, J. A.; Canal, I.; Hidalgo-Fernández, P.; Pérez-García, M. L.; Huertas, O.; Luque, F. J.

Chem. Eur. J., 2008, 14, 2277-2285

Non-degenerate p-Donor/p-Acceptor [2]Catenanes Containing Proton Ionizable 1H-1,2,4-Triazole Subunits: Synthesis and Spontaneous Resolution

Alcalde, E.; Perez-Garcia, L.; Ramos, S.; Stoddart, J. F.; White, A. J. P.; Williams, D. J.

Chem. Eur. J., 2007, 13, 3964-3979

Spontaneous Resolution, Whence and Whither: From Pasteur’s Enantiomorphic Solids to Chiral Liquid Crystals, Monolayers and Macro- and Supra-molecular Polymers

Pérez-García L., Amabilino, D.

Chem. Soc. Rev, 2007, 36, 941-967

Imidazolium-Based [14]Heterophanes as models for anion recognition

Alcalde, E.; Mesquida, N.; Pérez-García, L.

Eur. J. Org. Chem., 2006, 3988-3996

PhD theses submitted in the last three years

PhD Theses

Susana Ramos, 2002, Excellent cum laude

Lucía Casal Dujat-des Allimes, 2010, Excellent cum laude

Collaborations with other research groups

José Antonio Plaza, Institut de Microelectrònica de Barcelona, CSIC (Barcelona)

 Carme Nogués, Departament de Biologia cel·lular, Universitat Autònoma de Barcelona.

 Christian Sporer, Institut de Bioenginyeria de Catalunya, Barcelona

 Josep Samitier, Institut de Bioenginyeria de Catalunya i Departament de electrònica, Universitat de Barcelona

 Abdelhamid Errachid, Université de Lyon

 David Amabilino, Institut de Ciència de Materials de Barcelona, CSIC (Barcelona)

 J. Fraser Stoddart, University of Northwestern, USA

 Andrew J. P. White, Imperial College of London (England)

 Anna Calpena, Departament de Farmàcia i Tecnologia Farmacèutica, Universitat de Barcelona

 Peter Griffiths, University of Cardiff

Group members

Lluïsa Pérez-García (Associate Professor)

Lucía Casal (PhD student)

Oriol Penón (PhD student),

Mafalda Rodrigues (PhD student)