Cancer therapy group
 
 

Department of Biochemistry,

School of Pharmacy, University of Barcelona.

Av. Diagonal 643, 08028 Barcelona

Phone. (93) 403-4455, Fax: (93) 402-4520,

E-mail : CCiudad@ub.edu; vnoe@ub.edu

Updated: October-24-2011


OBJECTIVES


  1. •   To improve already existent cancer chemotherapy treatments to increase their effectivity.

  2. •    To study the regulation of genes involved in the resistance to chemotherapy

  3. •    To investigate new alternative therapies based on the new developments in Biochemistry and Molecular Biology.

  4. •    As a model we use the gene encoding for Dihydrofolate reductase (DHFR), enzyme that it is widely

       used as the target for the chemotherapy that uses methotrexate.


RESEARCH INTERESTS


  1. •   To study the process that develops resistance to chemotherapy.

  2. •    To find modulators of chemotherapy resistance

  3. •    To study the transcriptional regulation of the dhfr gene

  4. •    To study the effect of transcription factors, oncogenes and tumor suppressors on the expression of the dhfr gene.

  5. •    To investigate in detail the regulation of the transcription factor Sp1 and Sp3

  6. •    To explore the postranscriptional regulation of the DHFR RNA.

  7. •    To investigate the role of introns on the expression of the dhfr gene into protein

  8. •    Cloning of genes responsible for the resistance that arises upon cancer chemotherapy.

  9. •    Probing the applicability of antisense oligonucleotides and siRNA in cancer therapy

  10. •    Usage of aptamers to deliver gene therapy molecules to target cells .  

  11. •    To design immunoliposomes for introducing oligonucleotides into the cells.

  12. •    Identification of target genes involved in the activation of apoptosis and in the inhibition of angiogenesis: Survivin.

  13. •    To repair DNA mutations at the endogenous locus using Polypurine Hairpins.

  14. •    Genomic studies related to Methotrexate resistance: Arrays and MicroArrays

  15. •    Regulation of Methotrexate resistance by microRNAs  

  16. •    Networking of differentially expressed genes in methotrexate resistant cells

  17. •    Usage of polypurine hairpins against gene expression: Studies in vitro and in vivo

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