Cancer therapy group
 
 


Department of Biochemistry and Physiology,

School of Pharmacy, University of Barcelona.

Av. Juan XXIII #27, 08028 Barcelona

Phone. (93) 403-4455

E-mail : CCiudad@ub.edu; vnoe@ub.edu

Updated: May-17th-2019


OBJECTIVES


  1. To investigate new alternative cancer therapies using the developments in Biochemistry and Molecular Biology. 

  2. To improve our recently developed oligonucleotides: Polypurine Reverse Hoogsteen hairpins (PPRHs) for gene silencing, gene repair and gene editing

  3. To explore new delivery systems for oligonucleotide transfection in vitro and in vivo


 


RESEARCH INTERESTS


  1.    Design and usage of polypurine hairpins against gene expression: Studies in vitro and in vivo

  2.     Usage of aptamers to deliver gene therapy molecules to target cells.  

  3.     To design immunoliposomes for introducing oligonucleotides into the cells.

  4.    To repair DNA mutations at the endogenous locus using Polypurine Hairpins.

  5.     Genomic studies related to Methotrexate resistance. 

  6.     Networking of differentially expressed genes in methotrexate resistant cells.

  7.     To investigate the role of introns on the expression of proteins.

  8.     Explore the usage of new liposomes, gold nanoparticles and AAV particles to deliver the PPRHs.