OBJECTIVES

1. • To investigate new alternative cancer therapies using the developments in Biochemistry and Molecular Biology. 
   

2. • To improve our recently developed oligonucleotides: Polypurine Reverse Hoogsteen hairpins (PPRHs) for gene silencing, gene repair and gene editing
   

3. • To explore new delivery systems for oligonucleotide transfection in vitro and in vivo
   

 

RESEARCH INTERESTS

1. •   Design and usage of polypurine hairpins against gene expression: Studies in vitro and in vivo
   

2. •    Usage of aptamers to deliver gene therapy molecules to target cells.  
   

3. •    To design immunoliposomes for introducing oligonucleotides into the cells.
   

4. •    To repair DNA mutations at the endogenous locus using Polypurine Hairpins.
   

5. •    Genomic studies related to Methotrexate resistance. 
   

6. •    Networking of differentially expressed genes in methotrexate resistant cells.
   

7. •    To investigate the role of introns on the expression of proteins.
   

8. •    Explore the usage of new liposomes, gold nanoparticles and AAV particles to deliver the PPRHs.
   

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Research Projects