Cancer therapy group

Department of Biochemistry and Physiology,

School of Pharmacy, University of Barcelona.

Av. Juan XXIII #27, 08028 Barcelona

Phone. (93) 403-4455

E-mail :;

Updated: March-11th-2023


  1. To investigate new alternative cancer therapies using the developments in Biochemistry and Molecular Biology. 

  2. To improve our technology of Polypurine Reverse Hoogsteen hairpins (PPRHs) for gene silencing, gene repair, gene editing and as biosensors for diagnostics

  3. To explore new delivery systems for oligonucleotide transfection in vitro and in vivo



  1.    Design and usage of polypurine hairpins against gene expression: Studies in vitro and in vivo

  2.     Developing new liposomes, transfection agents and AAV particles to deliver the PPRHs.

  3.    To repair DNA mutations at the endogenous locus using Polypurine Hairpins.

  4.     To investigate the role of alternative splicing on the expression of proteins.

  5.     To develop PPRHs against non-druggable targets such as k-Ras and c-Myc

  6.     To develop PPRHs against PCSK9 to decrease cholesterol levels

  7.     Genomic studies related to Methotrexate resistance, including LncRNAs

  8.      Networking of differentially expressed genes in methotrexate resistant cells.