
Department of Biochemistry and Physiology,
School of Pharmacy, University of Barcelona.
Av. Juan XXIII #27, 08028 Barcelona
Phone. (93) 403-4455
E-mail : CCiudad@ub.edu; vnoe@ub.edu
Updated: July-16th-2021
OBJECTIVES
• To investigate new alternative cancer therapies using the developments in Biochemistry and Molecular Biology.
• To improve our technology of Polypurine Reverse Hoogsteen hairpins (PPRHs) for gene silencing, gene repair, gene editing and as biosensors for diagnostics
• To explore new delivery systems for oligonucleotide transfection in vitro and in vivo
RESEARCH INTERESTS
• Design and usage of polypurine hairpins against gene expression: Studies in vitro and in vivo
• Explore the usage of new liposomes, gold nanoparticles and AAV particles to deliver the PPRHs.
• To repair DNA mutations at the endogenous locus using Polypurine Hairpins.
• To investigate the role of alternative splicing on the expression of proteins.
• Usage of aptamers to deliver gene therapy molecules to target cells.
• Genomic studies related to Methotrexate resistance.
• Networking of differentially expressed genes in methotrexate resistant cells.