Publications

Selected Publications

from the last years

  • Benítez-García C, Martínez-García D, Kotev M, Pérez-Hernández M, Westermaier Y, Díaz L, Korrodi-Gregório L, Fontova P, Torres AA, Pérez-Tomás R, García-Valverde M, Quesada R, Soliva R, Soto-Cerrato V. Identification of the atypical antipsychotic Asenapine as a direct survivin inhibitor with anticancer properties and sensitizing effects to conventional therapies. Biomed Pharmacother, 2025.
  • Arias-Betancur A, Fontova P, Alonso-Carrillo D, Carreira-Barral I, Duis J, García-Valverde M, Soto-Cerrato V, Quesada R, Pérez-Tomás R. Deregulation of lactate permeability using a small-molecule transporter (Lactrans-1) disturbs intracellular pH and triggers cancer cell death. Biochem Pharmacol, 2024.
  • Alonso-Carrillo D, Arias-Betancur A, Carreira-Barral I, Fontova P, Soto-Cerrato V, García-Valverde M, Pérez-Tomás R, Quesada R. Small molecule anion carriers facilitate lactate transport in model liposomes and cells. iScience, 2023.
  • Espona-Fiedler M, Manuel-Manresa P, Benítez-García C, Fontova P, Quesada R, Soto-Cerrato V, Pérez-Tomás R. Antimetastatic Properties of Prodigiosin and the BH3-Mimetic Obatoclax (GX15-070) in Melanoma. Pharmaceutics, 2023.
  • Molero-Valenzuela A, Fontova P, Alonso-Carrillo D, Carreira-Barral I, Torres AA, García-Valverde M, Benítez-García C, Pérez-Tomás R, Quesada R, Soto-Cerrato V. A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer. Cancers, 2022.
  • Pérez-Hernández M, Cuscó C, Benítez-García C, Bonelli J, Nuevo-Fonoll M, Soriano A, Martínez-García D, Arias-Betancur A, García-Valverde M, Segura MF, Quesada R, Rocas J, Soto-Cerrato V, Pérez-Tomás R. Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug. Biomedicines, 2021.
  • Carreira-Barral I, Mielczarek M, Alonso-Carrillo D, Capurro V, Soto-Cerrato V, Perez Tomas R, Caci E, Garcıa-Valverde M and Quesada R. Click-tambjamines as efficient and tunable bioactive anion transporters. ChemComm, 2020.
  • Pérez-Hernández M, Arias A, Martínez-García D, Pérez-Tomás R, Quesada R, Soto-Cerrato V. Targeting autophagy for cancer treatment and tumor chemosensitization. Cancers, 2019.
  • Martínez-García D, Pérez-Hernández M, Korrodi-Gregório L, Quesada R, Ramos R, Baixeras N, Pérez-Tomás R, Soto-Cerrato V. The natural-based antitumor compound T21 decreases survivin levels through potent STAT3 inhibition in lung cancer models. Biomolecules, 2019.
  • Martínez-García D, Manero-Rupérez N, Quesada R, Korrodi-Gregório L, Soto-Cerrato V. Therapeutic strategies involving survivin inhibition in cancer. Med Res Rev 2018.
  • Hernando E, Capurro V, Cossu C, Fiore M, García-Valverde M, Soto-Cerrato V, Pérez-Tomás R, Moran O, Zegarra-Moran O, Quesada R. Small molecule anionophores promote transmembrane anion permeation matching CFTR activity. Sci Rep 2018.
  • Jowett LA, Howe ENW, Soto-Cerrato V, Van Rossom W, Pérez-Tomás R, Gale PA. Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents. Sci Rep 2017. 
  • Kotev M, Manuel-Manresa P, Hernando E, Soto-Cerrato V, Orozco M, Quesada R, Pérez-Tomás R, Guallar V. Inhibition of Human Enhancer of Zeste Homolog 2 with Tambjamine Analogs. J Chem Inf Model. 2017
  • Manuel-Manresa P, Korrodi-Gregório L, Hernando E, Villanueva A, Martínez-García D, Rodilla AM, Ramos R, Fardilha M, Moya J, Quesada R, Soto-Cerrato V, Pérez-Tomás R. Novel Indole-based Tambjamine-Analogues Induce Apoptotic Lung Cancer Cell Death through p38 Mitogen-Activated Protein Kinase Activation. Mol Cancer Ther 2017, 16(7):1224-1235.
  • Rodilla AM, Korrodi-Gregório L, Hernando E, Manuel-Manresa P, Quesada R, Pérez-Tomás R and Soto-Cerrato V. Synthetic tambjamine analogues induce mitochondrial swelling and lysosomal dysfunction leading to autophagy blockade and cell death in lung cancer. Biochemical Pharmacology 2017.
  • Korrodi-Gregório L, Soto-Cerrato V, Vitorino R, Fardilha M, Pérez-Tomás R. From Proteomic Analysis to Potential Therapeutic Targets: Functional Profile of Two Lung Cancer Cell Lines, A549 and SW900, Widely Studied in Pre-Clinical Research. PLoS One 2016, 4;11(11):e0165973.
  • Wu X, Judd LW, Howe ENW, Withecombe AM, Soto-Cerrato V, Li H, Busschaert N, Valkenier H, Pérez-Tomás R, Sheppard DN, Jiang Y, Davis AP, and Gale PA. Nonprotonophoric  electrogenic Cl− transport mediated by valinomycin-like carriers. Chem 2016, 1 (1): 127-46.
  • Soto-Cerrato V, Manuel-Manresa P, Hernando E, Calabuig-Farinas S, Martinez-Romero A, Fernandez-Duenas V, Sahlholm K, Knopfel T, Garcia-Valverde M, Rodilla AM et al: Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells. J Am Chem Soc 2015, 137(50):15892-15898.

To view all publications by each researcher:

ORCID ID Ricardo Pérez-Tomás: 0000-0003-3226-1240

ORCID ID Vanessa Soto-Cerrato: 0000-0001-5835-3595

ORCID ID Laura Devis-Jauregui: 0000-0003-3736-3983

ORCID ID Pere Fontova: 0000-0002-1352-3084