Genetics and genomics of neural wiring
Marta MoreyOur laboratory investigates how neural circuits are built, maintained, and reshaped in response to internal and external challenges. We approach this problem from two complementary angles:
-We study the genetic and molecular mechanisms that guide neuronal wiring during development using the Drosophila visual system as a model. This allows us to dissect how individual neurons acquire their identities, select specific synaptic partners, and assemble into layered circuits.
-We investigate neural plasticity in the adult, using the gut and its innervation as a model to uncover how environmental and physiological changes influence neuronal remodeling. This system enables us to identify the signals that drive adjustments in adult neuronal connectivity and to explore how these responses differ between the sexes.
Our goal is to uncover the molecular logic that underlies both robustness and flexibility in neural systems through the following research lines:
We use genetic tools and RNA sequencing to profile cell-type–specific neurons in the developing visual system. By comparing transcriptional signatures, we identify the molecular determinants that give each neuronal class its distinct morphology, physiology, and connectivity patterns.
We investigate how neurons with similar origins adopt different synaptic targets. Our work highlights key roles for combinations of cell-surface molecules (e.g., Dpr/DIP families) and other differentially expressed genes in instructing layer selection and synaptic partner choice. Using genetics, imaging, and protein tagging, we test the function of candidate molecules in vivo.
We aim to unravel the transcriptional logic that ensures precise layer-specific connectivity. By integrating RNAi screens, cis‑regulatory analyses, and chromatin‑based approaches, we investigate how transcription factors and regulatory modules coordinate the gene batteries required for accurate synaptic placement.
Glia provide more than trophic support: they also actively shape neural wiring. We study specific glial subpopulations in the fly visual system to understand how ion channels and glial signaling influence photoreceptor guidance and wiring.
We investigate neural plasticity in the adult, using the gut and its innervation as a model to uncover how environmental and physiological changes influence neuronal remodeling. This system enables us to identify the signals that drive adjustments in adult neuronal connectivity and to dissect sex dependent plasticity mechanisms relevant to circuit repair.
