A non-invasive strategy for focusing light deep inside biological tissue, with sub-cellular spatial resolution, and in real-time, does not exist.
Subcellular light focusing is the primary enabler of a number of characterization, diagnosis and treatment tools in biomedicine and life sciences, including microscopy and spectroscopy techniques or phototherapies. However, limited
by the scattering of light, current approaches are only optimized to operate at depths below a fraction of a millimeter inside tissue. Deeper light focusing – which is fundamental for sound biological conclusions or accurate treatments
–always comes at the expense of increased invasiveness, restricted sample availability, or loss of spatial or temporal precision.
We develop technologies based on ultrasound and artificial intelligence to overcome these issues and achieve an unprecedented control of light inside living systems