The research group develops and assesses nanostructured systems of controlled released in order to treat neurodegenerative diseases also including ocular inflammation.
Elena Sánchez López (Tenure-Track Lecturer) esanchezlopez(at)ub.edu
Espina García Marta (Associate Professor)
Gerard Esteruelas Navarro(Postdoctoral Researcher)
Lorena Bonilla Vidal (Postdoctoral Researcher)
M. Luisa García López (Emeritus)
Bonilla-Vidal L.; Espina M.; García M.L.; Baldomà L.; Badia J.; González J.A.; Delgado L.M.; Gliszczyńska A.; Souto E.B.; Sánchez-López E. Novel nanostructured lipid carriers loading Apigenin for anterior segment ocular pathologies. 2024, International Journal of Pharmaceutics, 658, 124222. Doi: 10.1016/j.ijpharm.2024.124222.
Vega E.; Burgos J.M.; Souto E.B.; García M.L.; Pujol M.; Sánchez-López E. Biodegradable nanoplatforms for antigen delivery: part I–state of the art review of polymeric nanoparticles for cancer immunotherapy. 2024, Expert Opinion on Drug Delivery, 21, 8. Doi: 10.1080/17425247.2024.2400293
Thiruchenthooran V.; Świtalska M.; Maciejewska G.; Palko-łabuz A.; Bonilla-Vidal L.; Wietrzyk J.; Souto E.B.; Sánchez-López E.; Gliszczyńska A. Multifunctional Indomethacin Conjugates for the Development of Nanosystems Targeting Cancer Treatment. 2024, International Journal of Nanomedicine, 19. 10.2147/IJN.S477512.
Thiruchenthooran V.; Espina M.; Świtalska M.; Bonilla-Vidal L.; Wietrzyk J.; Garcia M.L.; Souto E.B.; Sánchez-López E.; Gliszczyńska A. Combination of Indomethacin with Nanostructured Lipid Carriers for Effective Anticancer Therapy. 2024, International Journal of Nanomedicine, 19. 10.2147/IJN.S464239.
Novel strategies enhancing endodontic disinfection: Antibacterial biodegradable calcium hydroxide nanoparticles in an ex vivo model. Elmsmari F.; Delgado L.M.; Duran-Sindreu F.; Pérez R.A.; García M.L.; Teulé Trull M.; Afrashtehfar K.I.; González J.A.; Sánchez-López E. 2023, International Journal of Pharmaceutics, 648, 123627. Doi: 10.1016/j.ijpharm.2023.123627
Dually Active Apigenin-Loaded Nanostructured Lipid Carriers for Cancer Treatment. Bonilla-Vidal L.; Świtalska M.; Espina M.; Wietrzyk J.; García M.L.; Souto E.B.; Gliszczyńska A.; López E.S. 2023, International Journal of Nanomedicine, 18. Doi: 10.2147/IJN.S429565
Riluzole-Loaded Nanostructured Lipid Carriers for Hyperproliferative Skin Diseases. Llorente X.; Esteruelas G.; Bonilla L.; Agudelo M.G.; Filgaira I.; Lopez-Ramajo D.; Gong R.C.; Soler C.; Espina M.; García M.L.; Manils J.; Pujol M.; Sánchez-López E. 2023, International Journal of Molecular Sciences, 24, 9, 8053. Doi: 10.3390/ijms24098053
Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy. Esteruelas G.; Souto E.B.; Espina M.; García M.L.; Świtalska M.; Wietrzyk J.; Gliszczyńska A.; Sánchez-López E. 2023, Pharmaceutics, 15, 1, 102, Doi: 10.3390/pharmaceutics15010102
Galindo R., Sánchez-López E., Gómara M.J., Espina M., Ettcheto M., Cano A., Haro I., Camins A., García M.L. Development of Peptide Targeted PLGA-PEGylated Nanoparticles Loading Licochalcone-A for Ocular Inflammation. Pharmaceutics, 14, 2, 285, 2022
Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges. Bonilla L., Esteruelas G., Ettcheto M., Espina M., García M.L., Camins A., Souto E.B., Cano A., Sánchez-López E. Epilepsia Open, 7, S1, S121, S132, 2022
Therapeutic Approaches for Age-Related Macular Degeneration. Galindo-Camacho R.M., Blanco-Llamero C., da Ana R., Fuertes M.A., Señoráns F.J., Silva A.M., García M.L., Souto E.B. International Journal of Molecular Sciences, 23, 19, 11769, 2022
Novel Strategies against Cancer: Dexibuprofen-Loaded Nanostructured Lipid Carriers. Thiruchenthooran V., Świtalska M., Bonilla L., Espina M., García M.L., Wietrzyk J., Sánchez-López E., Gliszczyńska A. International Journal of Molecular Sciences, 23, 19, 11310, 2022
Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment. Folle C., Marqués A.M., Díaz-Garrido N., Espina M., Sánchez-López E., Badia J., Baldoma L., Calpena A.C., García M.L. Journal of Nanobiotechnology. 2021, 19, 1, 359
Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer’s disease: from current to future challenges. Cano A., Turowski P., Ettcheto M., Duskey J.T., Tosi G., Sánchez-López E., García M.L., Camins A., Souto E.B., Ruiz A., Marquié M., Boada M. Journal of Nanobiotechnology. 2021, 19, 1, 122.
Calcium hydroxide-loaded PLGA biodegradable nanoparticles as an intracanal medicament. Elmsmari F., González Sánchez J.A., Duran-Sindreu F., Belkadi R., Espina M., García M.L., Sánchez-López E. International Endodontic Journal. 2021, 54, 11
Psoriasis: From pathogenesis to pharmacological and nano-technological-based therapeutics. Petit R.G., Cano A., Ortiz A., Espina M., Prat J., Muñoz M., Severino P., Souto E.B., García M.L., Pujol M., Sánchez-López E. International Journal of Molecular Sciences, 2021, 22, 9, 4983
Recent advances on antitumor agents-loaded polymeric and lipid-based nanocarriers for the treatment of brain cancer. Cano A., Espina M., García M.L. Current Pharmaceutical Design, 2020, 26(12)
Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides. Gonzalez-Pizarro R., Parrotta G., Vera R., Sánchez-López E., Galindo R., Kjeldsen F., Badia J., Baldoma L., Espina M., García M.L. Nanomedicine, 2020, 14(23)
Nanopartícules per a la desinfecció en endodòncia. F2I-PdC_2021-002. IP1: M. Luisa García López/IP2: Elena Sánchez López. Convocatòria Prova de concepte 2021. Fons per a l’Impuls de la Innovació – Fundació Bosch i Gimpera. (2022-2023)
Comportamiento fisicoquímico y biofarmacéutico de nuevas nanoestructuras no lipídicas para la liberación de fármacos. PID2021-122187NB-C32. IP1: M. José García Celma/IP2: M. Luisa García López. Convocatoria 2021 de ayudas a «Proyectos de Generación de Conocimiento». Modalidad Proyectos de «Investigación No Orientada» Ministerio de Ciencia, Innovación y Universidades. (2022-2025)
Aplicación de criterios de calidad basada en el diseño al proceso de liofilización de sistemas nanoestructurados para el tratamiento de enfermedades neurodegenerativas. MAT2014-59134-R. IP: Garcia Lopez, M. Luisa. Ministerio de Economia y Competitividad. 2015-2017
Particle size analyzers (Nanozeta sizer y difracción lasser)
Homogenizers (ultrasound and high pression piston-gap)
Thermal Analysis Systems (DSC, TG, thermomicroscopy)
Otical Analyzer (Turbiscan Lab)
Liofilizers (Lyo Quest y Lyo Beta), SPRAY DRIED, ROTAVAPORES
Corneal camera, Franz cells
HPLC
Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
