Translational research into new strategies for diagnosis and treatment of disease liver. PI: Wladimiro Jimenez

Presentation

Our group is aimed at investigating the pathophysiological and molecular bases of the most frequent complications occurring in patients with chronic liver disease. All projects have a profound translational character, with special interest in identifying new therapeutic tools to stop or reverse the fibro-proliferative processes. We are committed to identify either, new biomarkers of liver injury and novel fibrogenesis signaling pathways. We also want to inhibit the activity of FoxO1 in hepatocytes or to modify the activity of specific targets of Akt with therapeutic potential. The general objective would be to stimulate functional liver regeneration in cirrhotic livers. Our research is also aimed at evaluating the therapeutic potential of Cerium oxide nanoparticles (CeO2NPs). These studies are carried out in experimental models of liver fibrosis, hepatocellular carcinoma and non-alcoholic steato hepatitis. Finally, we are developing cellular therapies to stimulate the regenerative capacity of cirrhotic livers by means of carbon nanoparticles that containing expression plasmids activating M2 phenotype.

Wladimiro Jimenez
PhD Associate professor
wjimenez@ub.edu

Manuel Morales Ruiz
PhD Assistant professor
morales@clinic.cat

Guillermo Fernández Varo
PhD CIBERehd researcher
guillermo.fernandez@ciberehd.org

Gregori Casals Mercadal
PhD Senior specialist, Hospital Clínic
casals@clinic.cat

Pedro Melgar Lesmes
PhD Postdoctoral researcher, Ramon y Cajal
pmelgar@clinic.cat

Jordi Ribera Sabater
PhD CIBERehd researcher
jordi.ribera@ciberehd.org

Bernardino Gonzalez de la Presa
PhD Senior specialist, Hospital Clínic
bgonzal@clinic.cat

Bernat Cordoba Jover
Predoctoral researcher, IDIBAPS
cordoba@clinic.cat

Alazne Moreno Lanceta
Fellow researcher FPI, IDIBAPS
amorenol@clinic.cat

Meritxell Perramon Corominas
Predoctoral researcher, Fundació Clínic
meri.perramon@gmail.com

Mireia Medrano Bosch
Fellow researcher FPU, UB
mmedrabo7@alumnes.ub.edu

Marina Parra Robert
Specialist, Hospital Clínic
mparra@clinic.cat

Mireia Medrano Bosch
Investigadora Becària FPU, UB
mmedrabo7@alumnes.ub.edu

  • To identify non-invasive biomarkers of liver injury and new signaling pathways of liver fibroproliferative processes.
  • To evaluate new strategies to inhibit hapatocyte activity of FoxO1 or to modify the activity of specific Akt targets that have a therapeutic potential to stimulate functional liver regeneration in cirrhotic livers.
  • To establish new therapies for the normalization of the intrahepatic vasculature in cirrhotic livers.
  • To evaluate the therapeutic potential of cerium oxide nanoparticles in experimental models of hepatocarcinoma and liver steatosis.
  • To evaluate the utility of matrix implants of collagen containing endothelial cells as cell therapy to stimulate the regenerative capacity of cirrhotic livers.
  • Modulation of macrophages to liver damage, regeneration and cancer through functionalized nanoparticles and gene therapy.

  • Effect of a new formulation of human serum albumin on systemic hemodynamics, inflammatory mediators and oxidative stress in rats with cirrhosis and ascites

PI: Wladimiro Jiménez Povedano.
Ref: European Foundation for the Study of Chronic Liver Failure
09/05/2016 continues in force

  • Utilidad terapeutica y de nuevos tratamientos para las enfermedades hepáticas. RNA de interferencia para PTTG1. Nanoparticulas de carbono grafito y donadores de óxido nítrico

PI: Wladimiro Jiménez Povedano
Ref; RTI2018-094734-B-C21, Ministerio de Ciencia, Innovación y Universidades
04/10/2016 to 31/12/2021

  • Development and application of ceria nanoparticles in the treatment of hepatocellular carcinoma

PI: Wladimiro Jiménez Povedano
Ref: Agència de gestió d’ajuts universitaris i de recerca. Ayudas de industria de Conocimiento (Llavor i Producte).
01/05/2019 to 31/01/2021

  • Estimulacion de la regeneracion funcional de higados cirroticos mediante la normalizacion vascular intrahepatica y la modulacion de dianas de Akt

PI: Manuel Morales Ruiz.
Ref: SAF2016-75358-R
30/12/2016 to 31/12/2020

  • Ceria nanoparticles for use in the treatment of hepatocellular carcinoma

PIs: Wladimiro Jimenez Povedano and Victor Franco Puntes.
Ref: CERCA-GINJOL (2017-02-002-CeNPsHCC-IDIBAPS)
01/01/2017 to 31/12/2019

  • Evaluación de las propiedades antioxidantes y antiinflamatorias de las nanopartículas de óxido de cerio como nueva estrategia terapéutica en la esteatosis hepática

PI: Gregori Casals Mercadal.
Ref: PI15/00777
01/01/2016 to 31/12/2018

  • Utilidad terapéutica de las nanopartículas de óxido de cerio en las enfermedades hepáticas

PIs: Wladimiro Jiménez Povedano and Guillermo Fernández Varo.
Ref: SAF2015-64126-R
01/01/2016 to 31/12/2018

  • Utilitat terapèutica de les nanopartícules d’óxid de ceri en la malaltia hepàtica

PI: Wladimiro Jiménez Povedano.
Ref: PERIS 2016-2020, SLT002/16/0034
01/04/2017 to 31/08/2018

For more information for PI publications click in the link:
ORCID: https://orcid.org/0000-0002-9376-0214

Neutrophil Gelatinase-Associated Lipocalin for Assessment of Acute Kidney Injury in Cirrhosis: A Prospective Study. Huelin P, Solà E, Elia C, Solé C, Risso A, Moreira R, Carol M, Fabrellas N, Bassegoda O, Juanola A, de Prada G, Albertos S, Piano S, Graupera I, Ariza X, Napoleone L, Pose E, Filella X, Morales-Ruiz M, Rios J, Fernández J, Jiménez W, Poch E, Torres F, Ginès P.Hepatology. 2019 Feb 27. doi: 10.1002/ hep.30592. [Epub ahead of print]. PMID: 30810244

Characterization of inflammatory response in hepatorenal syndrome: Relationship with kidney outcome and survival. Solé C, Solà E, Huelin P, Carol M, Moreira R, Cereijo U, Mas JM, Graupera I, Pose E, Napoleone L, dePrada G, Juanola A, Fabrellas N, Torres F, Morales-Ruiz M, Farrés J, Jiménez W, Ginès P.,Liver Int. 2018 Dec 29. doi: 10.1111/liv.14037. [Epub ahead of print] PMID: 30597709

Graphene-Dendrimer Nanostars for Targeted Macrophage Overexpression of Metalloproteinase 9 and Hepatic Fibrosis Precision Therapy. Melgar-Lesmes P, Luquero A, Parra-Robert M, Mora A, Ribera J, Edelman ER, Jiménez W.. Nano Lett 2018; 18 (9): 5839-5845.

Chondroitin sulfate attenuates atherosclerosis in ApoE Knockout mice involving cellular regulation of the inflammatory response. Melgar-Lesmes P, Sánchez-Herrero A, Lozano-Juan F, de la Torre Hernández JM, Montell E, Jiménez W, Edelman ER, Balcells M.. Thromb Haemost. 2018;118(7): 1329-1339.

Tweaking glutaraldehyde-fixed tissue heart valves with chondroitin sulfate hydrogel for endothelialization and shield against deterioration Lopez-Moya M, Melgar-Lesmes P, Kolandaivelu K, de la Torre Hernández JM, Edelman ER, Balcells M. Biomacromolecules. 2018;19(4): 1234-1244.

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Madiraju AK, Qiu Y, Perry RJ, Rahimi Y, Zhang XM, Zhang D, Camporez JG, Cline GW, Butrico GM, Kemp BE, Casals G, Steinberg GR, Vatner DF, Petersen KF, Shulman GI. Nat Med. 2018 Sep; 24(9):1384-1394. doi: 10.1038/ s41591-018-0125-4. Epub 2018 Jul 23.

Graphene-Dendrimer Nanostars for Targeted Macrophage Overexpression of Metalloproteinase 9 and Hepatic Fibrosis Precision Therapy. Melgar-Lesmes P, Luquero A, Parra-Robert M, Mora A, Ribera J, Edelman ER, Jiménez W. Nano Lett. 2018 Aug 16. doi: 10.1021/acs. nanolett.8b02498. [Epub ahead of print]

Chondroitin Sulphate Attenuates Atherosclerosis in ApoE Knockout Mice Involving Cellular Regulation of the Inflammatory Response. Melgar-Lesmes P, Sánchez-Herrero A, Lozano-Juan F, de la Torre Hernández JM, Montell E, Jiménez W, Edelman ER, Balcells M. Thromb Haemost. 2018 Jul;118(7): 1329-1339. doi: 10.1055/s-0038- 1657753. Epub 2018 Jun 6.

Optimizing Glutaraldehyde-Fixed Tissue Heart Valves with Chondroitin Sulfate Hydrogel for Endothelialization and Shielding against Deterioration. Lopez-Moya M, Melgar-Lesmes P, Kolandaivelu K, de la Torre Hernández JM, Edelman ER, Balcells M. Biomacromolecules. 2018 Apr 9;19(4): 1234-1244. doi: 10.1021/ acs.biomac. 8b00077. Epub 2018 Mar 20.

Validation of a routine gas chromatography mass spectrometry method for 2-hydroxyglutarate quantification in human serum as a screening tool for detection of idh mutations. Fernández-Galán E, Massana N, Parra-Robert M, Hidalgo S, Casals G, Esteve J, Jiménez W. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 15;1083: 28-34. doi: 10.1016 /j.jchromb. 2018.02.038. Epub 2018 Feb 28.

An evaluation of the SENTiFIT 270 analyser for quantitation of faecal haemoglobin in the investigation of patients with suspected colorectal cancer. Auge JM, Rodriguez C, Espanyol O, Rivero L, Sandalinas S, Grau J, Jimenez W, Castells A. Clin Chem Lab Med. 2018 Mar 28; 56(4): 625-633. doi: 10.1515/cclm- 2017-0605.

Translational evidence of prothrombotic and inflammatory endothelial damage in Cushing syndrome after remission. Aranda G, Fernandez-Ruiz R, Palomo M, Romo M, Mora M, Halperin I, Casals G, Enseñat J, Vidal O, Diaz-Ricart M, Hanzu FA. Clin Endocrinol (Oxf). 2018 Mar; 88(3):415-424. doi: 10.1111/ cen.13521. Epub 2017 Dec 17.

The GALA study: relationship between galectin-3 serum levels and short- and long-term outcomes of patients with acute heart failure. Miró Ò, González de la Presa B, Herrero-Puente P, Fernández Bonifacio R, Möckel M, Mueller C, Casals G, Sandalinas S, Llorens P, Martín-Sánchez FJ, Jacob J, Bedini JL, Gil V. Biomarkers. 2017 Dec; 22(8): 731-739. doi: 10.1080/1354750X. 2017.1319421. Epub 2017 May 2.

A small population of liver endothelial cells undergoes endothelial-to-mesenchymal transition in response to chronic liver injury. Ribera J, Pauta M, Melgar-Lesmes P, Córdoba B, Bosch A, Calvo M, Rodrigo-Torres D, Sancho-Bru P, Mira A, Jiménez W, Morales-Ruiz M. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5): G492-G504. doi: 10.1152/ ajpgi.00428. 2016. Epub 2017 Aug 10.

Circulatory Immune Cells in Cushing Syndrome: Bystanders or Active Contributors to Atherometabolic Injury? A Study of Adhesion and Activation of Cell Surface Markers. Aranda G, Lopez C, Fernandez-Ruiz R, Esteban Y, Garcia-Eguren G, Mora M, Halperin I, Casals G, Enseñat J, Hanzu FA. Int J Endocrinol. 2017; 2017: 2912763. doi: 10.1155/ 2017/2912763. Epub 2017 Sep 20.

Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide.Casals E, Gusta MF, Piella J, Casals G, Jiménez W, Puntes V. Front Immunol. 2017 Aug 14;8:970. doi: 10.3389/ fimmu. 2017.00970. eCollection 2017. Review. Erratum in: Front Immunol. 2017 Dec 22;8:1891.

Pulsatility and high shear stress deteriorate barrier phenotype in brain microvascular endothelium. Garcia-Polite F, Martorell J, Del Rey-Puech P, Melgar-Lesmes P, O'Brien CC, Roquer J, Ois A, Principe A, Edelman ER, Balcells M. J Cereb Blood Flow Metab. 2017 Jul;37(7): 2614-2625. doi: 10.1177/ 0271678X16672482. Epub 2016 Jan 1.

Implantation of healthy matrix-embedded endothelial cells rescues dysfunctional endothelium and ischaemic tissue in liver engraftment. Melgar-Lesmes P, Balcells M, Edelman ER. Gut. 2017 Jul;66(7): 1297-1305. doi: 10.1136/ gutjnl- 2015-310409. Epub 2016 Feb 5.

Early in vitro development of daptomycin non-susceptibility in high-level aminoglycoside-resistant Enterococcus faecalis predicts the efficacy of the combination of high-dose daptomycin plus ampicillin in an in vivo model of experimental endocarditis. Pericàs JM, García-de-la-Mària C, Brunet M, Armero Y, García-González J, Casals G, Almela M, Quintana E, Falces C, Ninot S, Fuster D, Llopis J, Marco F, Moreno A, Miró JM; Hospital Clinic Endocarditis Study Group. J. Antimicrob Chemother. 2017 Jun 1;72(6): 1714-1722. doi: 10.1093 /jac/dkx016.

Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes. Graupera I, Coll M, Pose E, Elia C, Piano S, Solà E, Blaya D, Huelin P, Solé C, Moreira R, de Prada G, Fabrellas N, Juanola A, Morales-Ruiz M, Sancho-Bru P, Villanueva C, Ginès P. Sci Rep. 2017 May 12;7(1): 1829. doi: 10.1038/ s41598-017- 01709-0.

Effects of alfapump™ system on kidney and circulatory function in patients with cirrhosis and refractory ascites. Solà E, Sanchez-Cabús S, Rodriguez E, Elia C, Cela R, Moreira R, Pose E, Sánchez-Delgado J, Cañete N, Morales-Ruiz M, Campos F, Balust J, Guevara M, García-Valdecasas JC, Ginès P. Liver Transpl. 2017 May; 23(5): 583-593. doi: 10.1002/ lt.24763.

The Role of Akt in Chronic Liver Disease and Liver Regeneration. Morales-Ruiz M, Santel A, Ribera J, Jiménez W. Semin Liver Dis. 2017 Feb;37(1):11-16. doi: 10.1055/ s-0036- 1597819. Epub 2017 Feb 15. Review.

Cost-effectiveness of enhanced liver fibrosis test to assess liver fibrosis in chronic hepatitis C virus and alcoholic liver disease patients. Soto M, Sampietro-Colom L, Lasalvia L, Mira A, Jiménez W, Navasa M. World Journal of Gastroenterology, 2017; 23: 3163-3173.  doi: 10.3748/wjg.v23.i17.3163.

Identification of the potentially arrhythmogenic substrate in the acute phase of ST-segment elevation myocardial infarction. Penela D, Acosta J, Andreu D, Ortiz-Perez JT, Bosch X, Perea RJ, de Caralt TM, Fernández-Armenta J, Soto-Iglesias D, Prat-Gonzalez S, Borràs R, Mont L, Hervas V, Morales-Ruiz M, Jiménez W, Mira A, Donnelly J, Ekinci O, Lasalvia L, Berruezo A. Heart Rhythm. 2017 Apr;14(4): 592-598. doi: 10.1016/j.hrthm. 2017.01.019. Epub 2017 Jan 17.

Prognostic value of plasma apelin concentrations at admission in patients with ST-segment elevation acute myocardial infarction. Sans-Roselló J, Casals G, Rossello X, González de la Presa B, Vila M, Duran-Cambra A, Morales-Ruiz M, Ferrero-Gregori A, Jiménez W, Sionis A. Clin Biochem. 2017 Apr;50(6):279-284. doi: 10.1016/ j.clinbiochem. 2016.11.018. Epub 2016 Nov 24.

Prognostic prediction by liver tissue proteomic profiling in patients with colorectal liver metastases. Reyes A, Marti J, Marfà S, Jiménez W, Reichenbach V, Pelegrina A, Fondevila C, Garcia Valdecasas JC, Fuster J.Future Oncol. 2017 Jan 16. doi: 10.2217/fon-2016-0461.

Zinc alpha-2 glycoprotein is overproduced in Cushing's syndrome. Escoté X, Aranda GB, Mora M, Casals G, Enseñat J, Vidal O, Esteban Y, Halperin I, Hanzu FA. Endocrinol Diabetes Nutr. 2017 Jan;64(1):26-33. doi: 10.1016/ j.endinu. 2016.10.002. Epub 2017 Jan 18. English, Spanish.

Characterization of Inflammatory Response in Acute-on-Chronic Liver Failure and Relationship with Prognosis. Solé C, Solà E, Morales-Ruiz M, Fernàndez G, Huelin P, Graupera I, Moreira R, de Prada G, Ariza X, Pose E, Fabrellas N, Kalko SG, Jiménez W, Ginès P. Sci Rep. 2016 Aug 31; 6:32341. doi: 10.1038/srep32341.

Early non-invasive selection of patients at high risk of severe hepatitis C recurrence after liver transplantation. Crespo G, Gambato M, Millán O, Casals G, Ruiz P, Londoño MC, Mira A, Forns X, Brunet M, Jiménez W, Navasa M. Transpl Infect Dis. 2016;18(3):471-9. doi: 10.1111/tid.12526.

Urine Monocyte Chemoattractant Protein-1 Is an Independent Predictive Factor of Hospital Readmission and Survival in Cirrhosis. Graupera I, Solà E, Fabrellas N, Moreira R, Solé C, Huelin P, de la Prada G, Pose E, Ariza X, Risso A, Albertos S, Morales-Ruiz M, Jiménez W, Ginès P. PLoS One. 2016 Jun 30;11(6):e0157371. doi: 10.1371/ journal.pone. 0157371. 

Plasma copeptin as biomarker of disease progression and prognosis in cirrhosis. Solà E, Kerbert AJ, Verspaget HW, Moreira R, Pose E, Ruiz P, Cela R, Morales-Ruiz M, López E, Graupera I, Solé C, Huelin P, Navarro AA, Ariza X, Jalan R, Fabrellas N, Benten D, de Prada G, Durand F, Jimenez W, van der Reijden JJ, Fernandez J, van Hoek B, Coenraad MJ, Ginès P. J Hepatol. 2016; 65(5):914-920. doi: 10.1016/j.jhep. 2016.07.003.

Metastatic Tissue Proteomic Profiling Predicts 5-Year Outcomes in Patients with Colorectal Liver Metastases. Marfà S, Marti J, Reyes A, Casals G, Fernández-Varo G, Carvajal S, García-Valdecasas JC, Fuster J, Jiménez W. Transl Oncol. 2016; 9(5): 445-452. doi: 10.1016/j.tranon.2016.08.002.

Utility of galectin-3 in predicting post-infarct remodeling after acute myocardial infarction based on extracellular volume fraction mapping. Perea RJ, Morales-Ruiz M, Ortiz-Perez JT, Bosch X, Andreu D, Borras R, Acosta J, Penela D, Prat-González S, de Caralt TM, Martínez M, Morales-Romero B, Lasalvia L, Donnelly J, Jiménez W, Mira A, Mont L, Berruezo A. Int J Cardiol. 2016; 223:458-464. doi: 10.1016/j.ijcard. 2016.08.070.

Sipa1l1 is an early biomarker of liver fibrosis in CCl4-treated rats. Marfà S, Morales-Ruiz M, Oró D, Ribera J, Fernández-Varo G, Jiménez W. Biol Open. 2016 ;5(6): 858-65. doi: 10.1242/ bio.018887

Accuracy of immunoassay and mass spectrometry urinary free cortisol in the diagnosis of Cushing's syndrome. Aranda G, Careaga M, Hanzu FA, Patrascioiu I, Ríos P, Mora M, Morales-Romero B, Jiménez W, Halperin I, Casals G. Pituitary 2016;19 (5):496-502. doi: 10.1007/s11102-016-0730-5.

Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis. X.Ariza, I.Graupera, M.Coll, R.Barreto, E.García, R. Moreira, C.Elia, M.Morales-Ruiz,, M.Llopis, P.Huelin, C.Solé, N.Fabrellas, E.Weiss, F.Nevens, A.Gerbes, J.Trebicka, F.Saliba, C.Fondevila, V.Hernández-Gea, J.Fernández, W.Jiménez, C.Deulofeu, M.Pavesi, P.Angeli, R.Jalan, R.Moreau, M.Bernardi,  V.Arroyo, P.Sancho-Bru, and P.Ginès. Journal Hepatology, 2016 Jul; 65(1): 57-65. doi:   10.1016/ j.jhep.2016.03.002.

Early non-invasive selection of patients at high risk of severe hepatitis C recurrence after liver transplantation. G.Crespo, M.Gambato, O.Millán, G.Casals, P.Ruiz, M.C.Londoño, A.Mira, X.Forns, M.Brunet, W.Jimenez, M.Navasa. Transplant Infectious Disease, 2016 Jun;18(3):471-9. doi: 10.1111/tid.12526.

Akt-mediated FoxO1 inhibition is required for liver regeneration after partial hepatectomy in mice. M.Pauta, N.Rotllan, A. Fernandez-Hernando, C. Langhi, J.Ribera, L.Boix, J.Bruix, W.Jiménez, Y.Suarez, D.A.Ford, A.Baldan, M.Birnbaum, M.Morales-Ruiz, C.Fernandez-Hernando. Hepatology, 2016; 63(5):1660-74.  doi: 10.1002/hep.28286.

Vasopressin 1α receptor partial agonism increases sodium excretion and reduces portal hypertension and ascites in cirrhotic rats. G.Fernández-Varo, D.Oró, E.E.Cable, V. Reichenbach, S. Carvajal, B. González de la Presa, K. Wiśniewski, P. Ginés, G. Harris, W. Jiménez. Hepatology, 2016; 63(1):207-16. doi: 10.1002/hep.28250. [Epub ahead of print]

Cerium oxide nanoparticles reduce steatosis, portal hypertension and display antiinflammatory properties in rats with liver fibrosis. Oró D, Yudina T, Fernández-Varo G, Casals E, Reichenbach V, Casals G, González de la Presa B, Sandalinas S, Carvajal S, Puntes V, Jiménez W. Journal Hepatology , 2016;64 :691-8. doi: 10.1016/ j.jhep.2015. 10.020.

Monocyte-endothelial cell interactions in the regulation of vascular sprouting and liver regeneration in mouse. Melgar-Lesmes P,  Edelman ER. J Hepatol; 2015; 63(4): 917-925.

Clinical utility of one versus two faecal immunochemical test samples in the detection of advanced colorectal neoplasia in symptomatic patients. Auge JM, Fraser CG, Rodriguez C, Roset A, Lopez-Ceron M, Grau J, Castells A,  Jimenez W. Clin Chem Med Lab, 2015; doi: 10.1515/cclm-2015-0388.

Formation of Δ(1) and Δ(6) testosterone metabolites by human hepatocytes. Fabregat A,  Marcos J,  Ventura R, Casals G, Jimenez W, Reichenbach V, Segura J, Pozo OJ. Steroids 2015; 95: 66-72. doi: 10.1016 /j.steroids. 2014.12.006. Epub 2014 Dec 23.

Analysis of a urinary biomarker panel for clinical outcomes assessment in cirrhosis. Ariza X, Solà E, Elia C, Barreto R, Moreira R, Morales-Ruiz M, Graupera I, Rodríguez E, Huelin P, Solé C, Fernández J, Jiménez W, Arroyo V, Ginès P. PLoS One. 2015, Jun 4;10(6):e0128145. doi: 10.1371/ journal.pone. 0128145.

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC.  Proc Natl Acad Sci U S A; 2014; 111(35): 12865-12870

Risk stratification for advanced colorectal neoplasia according to fecal hemoglobin concentration in a colorectal cancer screening program. Auge JM, Pellise M, Escudero JM, Hernandez C, Andreu M, Grau J, Buron A, López-Cerón M, Bessa X, Serradesanferm A, Piracés M, Macià F, Guayta R, Filella X, Molina R, Jimenez W, Castells A.Gastroenterology 2014; 147: 628-636.

Lack of a 5.9 kDa Peptide C-Terminal Fragment of Fibrinogen α Chain Precedes Fibrosis Progression in Patients with Liver Disease. Marfà S, Crespo G, Reichenbach V, Forns X, Casals G, Morales-Ruiz M, Navasa M, Jiménez W.  PLoS One. 2014 Oct doi: 10.1371/ journal.pone. 0109254.

Real-time PCR PCA3 assay is a useful test measured in urine to improve prostate cancer detection. Foj L, Milà M, Mengual L, Luque P, Alcaraz A, Jiménez W, Filella X.Clin Chim Acta. 2014; 435: 53-8. doi: 10.1016/j.cca.2014.04.025. Epub 2014

The influence of prostate volume in prostate health index performance in patients with total PSA lower than 10μg/L. Filella X, Foj L, Alcover J, Augé JM, Molina R, Jiménez W.Clin Chim Acta. 2014; 436C:303-307. doi: 10.1016 /j.cca. 2014.06.019.

Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition. Pauta M, Ribera J, Melgar-Lesmes P, Casals G, Rodríguez-Vita J, Reichenbach V, Fernandez-Varo G, Morales-Romero B, Bataller R, Michelena J, Altamirano J, Jiménez W, Morales-Ruiz M. Liver International. 2014;  doi: 10.1111/liv.12505

Urinary neutrophil gelatinase-associated lipocalin predicts kidney outcome and death in patients with cirrhosis and bacterial infections. Barreto R, Elia C, Solà E, Moreira R, Ariza X, Rodríguez E, Graupera I, Alfaro I, Morales-Ruiz M, Poch E, Guevara M, Fernández J, Jiménez W,  Arroyo V, Ginès P. J Hepatol. 2014  doi: 10.1016/j. jhep.2 014.02.023. [Epub ahead of print]

Microwave-assisted derivatization: application to steroid profiling by gas chromatography/mass spectrometry. Casals G,  Oscar J.M., Pozo J., Alcaraz J, Martínez de Osaba MJ,  Jiménez W. J  Chromatography B http: //dx.doi.org/doi:10. 1016/ j.jchromb. 2014.04.015.

Factors involved in extracellular matrix turnover in human derived cardiomyocytes. Casals G, Fernández-Varo G, Melgar-Lesmes P, Marfà S, Reichenbach V, Morales-Ruiz M, Jiménez W. Cell Physiol Biochem, 2013 11;32(5): 1125-1136.

PCA3 in the detection and management of early prostate cancer. Filella X, Foj L, Milà M, Augé JM, Molina R, Jiménez W. Tumour Biol. 2013; 34: 1337-47.

Impaired liver regeneration in Ldlr(-)(/)(-) mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids. Pauta M, Rotllan N, Vales F, Fernandez-Hernando A, Allen RM, Ford DA, Marí M, Jiménez W, Baldán A, Morales-Ruiz M, Fernández-Hernando C. J Hepatol. 2013; 59: 731-7.

Relative adrenal insufficiency in decompensated cirrhosis: Relationship to short-term risk of severe sepsis, hepatorenal syndrome, and death. Acevedo J, Fernández J, Prado V, Silva A, Castro M, Pavesi M, Roca D, Jimenez W, Ginès P, Arroyo V. Hepatology. 2013 May 31. doi: 10.1002/hep.26535. Epub 2013 Aug 7.

Bacterial lipopolysaccharide inhibits CB2 receptor expresión in human monocític cells (Letter). Reichenbach V, Muñoz-Luque J, Ros J, Casals G, Navasa M, Fernández-Varo G, Morales-Ruiz M, Jimenez W.  Gut, 2013; 62: 1089-1091.

Protein fingerprint of the extracellular matrix remodelling in experimental liver fibrosis. A serological evaluation. Leeming DJ., Byrjalssen I., Vassiliadis E., Veidal SS., Jimenez W., Christiansen C., Karsdal MA. Liver International, 2013; 33: 439-447.

Adenoviral dominant-negative soluble PDGFRβ improves hepatic collagen, systemic hemodynamics and portal pressure in fibrotic rats. Reichenbach V., Fernández-Varo G., Casals G., Oró D., Ros J., Melgar-Lesmes P., Weiskirchen R.. Morales-Ruiz M., W. Jiménez.  Journal Hepatology, 2012; 57: 967-973.

Admission B-type natriuretic peptide retains prognostic value in patients with acute coronary syndrome and preserved left ventricular ejection fraction. Casals G,  Azzalini L, Tomas C, Marfa S, Morales-Ruiz M, Heras M. Jimenez   W,  Sionis A. Int J Cardiology, 2012; 158: 459-460.

Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis. Gonçalve C, Pépin MN, Guevara M, Barreto R, Casals G, Solà E, Pereira G, Rodríguez E, Garcia E, Poch E, Jiménez W, Fernández J, Arroyo V, Ginès P. Journal Hepatology, 2012; 57: 267-273.

ARFI, Fibroscan, ELF, and their combinations in the assessment of liver fibrosis: a prospective study. Crespo G, Fernández-Varo G, Mariño Z; Casals G; Miquel R; Martínez SM; Gilabert R, Forns X; Jiménez W, Navasa M. Journal Hepatology, 2012; 57: 281-287.

Increased nitric oxide production in lymphatic endothelial cells causes impairment of lymphatic drainage in cirrhotic rats. JRibera J, Pauta M, Melgar-Lesmes P, Tugues S, Fernández-Varo G, Held KF, Soria G, Tudela R, Planas AM, Fernández-Hernando C, Arroyo V, Jiménez W, Morales-Ruiz M. Gut, 2013; 62: 138-145.

Prevention of fibrosis progression in CCl4-treated rats. Role of the hepatic endocannabinoid and apelin systems. Reichenbach V, Ros J, Fernández-Varo G, Casals G, Melgar Lesmes P, Campos T, Makriyannis A, Morales Ruiz M, Jimenez W. J Pharm Exp Ther, 2012, ;340: 629-37.

Circulating CO3-610, a degradation product of collagen iii, closely reflects liver collagen and portal pressure in rats with fibrosis. Segovia-Silvestre T, Reichenbach V, Fernández-Varo G, Vassiliadis E, Barascuk N, Morales-Ruiz M, Karsdal MA, Jiménez W, Fibrogenesis & Tissue Repair, 2011,  4:19, doi:10.1186/1755-1536-4-19.

Hypoxia and proinflammatory factors up-regulate apelin receptor expression in human stellate cells and hepatocytes. Melgar-Lesmes P, Pauta M, Reichenbach V, Casals G, Ros J, Bataller R, Morales-Ruiz M, Jimenez W. Gut, 2011 60(10):1404-11

Assessment of liver fibrosis before and after antiviral therapy by different serum marker panels in patients with chronic hepatitis C. Martinez SM, Fernández-Varo G, Gonzalez P, Sampson E, Bruguera M, Navasa M,  Jiménez W, Sánchez JM, Forns X. Alimentary Pharmacology & Therapeutics, 2011; 33: 138-148.

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