Present position:
Consultor of the Human Reproduction Unit and Head of Reproductive Andrology Unit of the Institute of Gynecology, Obstetrics and Neonatology, Hospital Clínic from Barcelona.
Academic training and speciality:
Medical Doctor and Gynecologist (1978), Faculty of Medicine, University of Barcelona.
Associate Professor of Gynaecology, Faculty of Medicine, University of Barcelona (1978-89)
Training abroad:
-Department of Obstetrics and Gynecology at Nuffield Hospital (Oxford, 1977),
-Department of Physiology of Reproduction at the Karolinska Institutet (Stockholm, 1978)
-Reproduction Unit, University Hospital Gasthuisberg (Leuven, 1985)
Organisation of scientific meetings:
-Chairman of the Scientific Committee of the Ninth National Congress of the Spanish Association of Andrology (Oviedo, 1999)
-Chairman of the Organizing Committee of the 9th International Congress of Andrology, XIV Congress of the Spanish Association of Andrology, XI Iberian Andrology Day and IV Latin American encounter of Andrology (held together in Barcelona, 2009)
-Member of the Scientific Committee of the V Latin American Encounter of Andrology (Buenos Aires, April 2012)
Member of scientific Societies:
- Asociación Iberoamericana de Sociedades de Andrología (ANDRO):
▪ Founding Member
▪ President (2004-2006)
- Asociación Española de Andrología (ASESA):
▪ Founding Member
▪ President (2001-05)
▪ Treasurer (1997-2001)
▪ Vicesecretary (1993-97)
▪ Honour Member (since 2006)
- Sociedad Española de Fertilidad (SEF):
▪ Member of the Board of Directors (2000-01)
▪ Member of the Commission on Ethics and Good Praxis
- European Society for Human Reproduction and Embriology (ESHRE)
- American Society of Andrology (ASA)
- Member of the Comisión Nacional de Reproducción Humana Asisitida (CNRHA)
- Emeritus Member of the Centro de Estudios del Hospital de Santa Mônica (Vila-Velha, Espirito Santo, Brasil)
Publications
35: Barrachina F, de la Iglesia A, Jodar M, Soler-Ventura A, Mallofré C, Rodriguez-Carunchio L, Goudarzi A, Corral JM, Ballescà JL, Castillo J, Oliva R.
Histone H4 acetylation is dysregulated in active seminiferous tubules adjacent to testicular tumours.
Hum Reprod 2022;37:1712-1726
34: de la Iglesia A, Jauregi P, Jodar M, Barrachina F, Ded L, Mallofré C, Rodríguez-Carunchio L, Corral JM, Ballescà JL, Komrskova K, Castillo J, Oliva R.
H4K5 butyrylation coexist with acetylation during human spermiogenesis and are retained in the mature sperm chroma-tin.
Int J Mol Sci 2022;23:12398.
33: Jodar M, Attardo-Parrinello C, Soler-Ventura A, Barrachina F, Delgado-Dueñas D, Cívico S, Calafell JM, Ballescà JL, Oliva R.
Sperm proteomic changes associated to early embryo quality after ICSI.
Reproductive Biomedicine Online. 2020; 40(5):700-710. doi: 10.1016/j.rbmo.2020.01.004
32: Soler-Ventura A, Gay M, Jodar M, Vilanova M, Castillo J, Arauz-Garofalo G, Villarreal L, Ballescà JL, Vilaseca M, Oliva R.
Characterization of human sperm protamine proteoforms through a combination of top-down and bottom-up mass spectrometry approaches.
Journal of Proteome Research. 2020 19(1):221-237. doi: 10.1021/acs.jproteome.9b00499
31: Castillo J, Bogle OA, Jodar M, Torabi F, Delgado-Dueñas D, Estanyol JM, Ballescà JL, Miller D, Oliva R.
Proteomic changes in human sperm during sequential in vitro capacitation and acrosome reaction.
Frontiers in Cell and Develop Biology. 2019. 20;7:295. doi: 10.3389/fcell.2019.00295
30: Alvarez-Palomo B, Barrot-Feixat C, Sarret H, Requena J, Pau M, Vidal-Taboada JM, Oliva R, Ballesca JL, Edel MJ, Mezquita-Pla J.
Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases.
Oncotarget 2019. Oct 8;10(56):5871-5887. doi: 10.18632/oncotarget.27232
29: Barrachina F, Jodar M, Delgado-Dueñas D, Soler-Ventura A, Estanyol JM, Mallofré C, Ballesca JL, Oliva R.
Stable-protein Pair Analysis as A Novel Strategy to Identify Proteomic Signatures: Application To Seminal Plasma From Infertile Patients.
Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S77-S90. doi: 10.1074/mcp.RA118.00124
28: Soler-Ventura A, Castillo J, de la Iglesia A, Jodar M, Barrachina F, Ballesca JL, Oliva R.
A Step-By-Step Protocol For Mammalian Sperm Protamine Extraction And Analysis.
Protein Pept Lett
27: Bogle OA, Kumar K, Attardo-Parrinello C, Lewis SE, Estanyol JM, Ballescà JL, Oliva R.
Identification of protein changes in human spermatozoa throughout the cryopreservation process.
Andrology. 2017 Jan;5(1):10-22
26: Castillo J, Estanyol JM, Ballescá JL, Oliva R.
Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility.
Asian J Androl. 2015;17:601-9.
25: Pantano L, Jodar M, Bak M, Ballescà JL, Tommerup N, Oliva R, Vavouri T.
The small RNA content of human sperm reveals pseudogene-derived piRNAs complementary to protein-coding genes.
RNA. 2015;21:1085-95.
24: Codina M, Estanyol JM, Fidalgo MJ, Ballescà JL, Oliva R.
Advances in sperm proteomics: best-practise methodology and clinical potential.
Expert Rev Proteomics. 2015;12:255-77.
23: Paiva C, Amaral A, Rodriguez M, Canyellas N, Correig X, Ballescà JL, Ramalho-Santos J, Oliva R.
Identification of endogenous metabolites in human sperm cells using proton nuclear magnetic resonance ((1) H-NMR) spectroscopy and gas chromatography-mass spectrometry (GC-MS).
Andrology. 2015;3:496-505.
22: Amaral A, Paiva C, Attardo Parrinello C, Estanyol JM, Ballescà JL, Ramalho-Santos J, Oliva R.
Identification of proteins involved in human sperm motility using high-throughput differential proteomics.
J Proteome Res. 2014;13:5670-84.
21: Castillo J, Amaral A, Azpiazu R, Vavouri T, Estanyol JM, Ballescà JL, Oliva R.
Genomic and proteomic dissection and characterization of the human sperm chromatin.
Mol Hum Reprod. 2014;20:1041-53.
20: Azpiazu R, Amaral A, Castillo J, Estanyol JM, Guimerà M, Ballescà JL, Balasch J, Oliva R.
High-throughput sperm differential proteomics suggests that epigenetic alterations contribute to failed assisted reproduction.
Hum Reprod. 2014;29:1225-37.
19: Amaral A, Castillo J, Estanyol JM, Ballesca JL, Ramalho-Santos J, Oliva R.
Human sperm tail proteome suggests new endogenous metabolic pathways.
Mol Cell Proteomics. 2013 Feb;12(2):330-42.
18: Jodar M, Kalko S, Castillo J, Ballescà JL, Oliva R.
Differential RNAs in the sperm cells of asthenozoospermic patients.
Hum Reprod. 2012;27:1431-8.
17: Oliva R, Ballescà JL.
Altered histone retention and epigenetic modifications in the sperm of infertile men.
Asian J Androl. 2012;14:239-40.
16: de Mateo S, Castillo J, Estanyol JM, Ballescà JL, Oliva R.
Proteomic characterization of the human sperm nucleus.
Proteomics. 2011;11:2714-26.
15: Oliva R, De Mateo S, Castillo J, Azpiazu R, Oriola J, Ballescà JL.
Methodological advances in sperm proteomics.
Hum Fertil (Camb). 2010 Dec;13(4):263-7
14: Jodar M, Oriola J, Mestre G, Castillo J, Giwercman A, Vidal-Taboada JM, Ballescà JL, Oliva R.
Polymorphisms, haplotypes and mutations in the protamine 1 and 2 genes.
Int J Androl. 2011;34:470-85
13: de Mateo S, Gázquez C, Guimerà M, Balasch J, Meistrich ML, Ballescà JL, Oliva R.
Protamine 2 precursors (Pre-P2), protamine 1 to protamine 2 ratio (P1/P2), and assisted reproduction outcome.
Fertil Steril. 2009;91:715-22.
12: Krausz C, Giachini C, Xue Y, O'Bryan MK, Gromoll J, Rajpert-de Meyts E, Oliva R, Aknin-Seifer I, Erdei E, Jorgensen N, Simoni M, Ballescà JL, Levy R, Balercia G, Piomboni P, Nieschlag E, Forti G, McLachlan R, Tyler-Smith C.
Phenotypic variation within European carriers of the Y-chromosomal gr/gr deletion is independent of Y-chromosomal background.
J Med Genet. 2009 Jan;46(1):21-31.
11: Gázquez C, Oriola J, de Mateo S, Vidal-Taboada JM, Ballescà JL, Oliva R.
A common protamine 1 promoter polymorphism (-190 C->A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients.
J Androl. 2008 Sep-Oct;29(5):540-8.
10: Martínez-Heredia J, de Mateo S, Vidal-Taboada JM, Ballescà JL, Oliva R.
Identification of proteomic differences in asthenozoospermic sperm samples.
Hum Reprod. 2008 Apr;23(4):783-91.
9: de Mateo S, Martínez-Heredia J, Estanyol JM, Domínguez-Fandos D, Vidal-Taboada JM, Ballescà JL, Oliva R.
Marked correlations in protein expression identified by proteomic analysis of human spermatozoa.
Proteomics. 2007 Dec;7(23):4264-77
8: Domínguez-Fandos D, Camejo MI, Ballescà JL, Oliva R.
Human sperm DNA fragmentation: correlation of TUNEL results as assessed by flow cytometry and optical microscopy.
Cytometry A. 2007 Dec;71(12):1011-8
7: Torregrosa N, Domínguez-Fandos D, Camejo MI, Shirley CR, Meistrich ML, Ballescà JL, Oliva R.
Protamine 2 precursors, protamine 1/protamine 2 ratio, DNA integrity and other sperm parameters in infertile patients.
Hum Reprod. 2006 Aug;21(8):2084-9.
6: Martínez-Heredia J, Estanyol JM, Ballescà JL, Oliva R.
Proteomic identification of human sperm proteins.
Proteomics. 2006 Aug;6(15):4356-69
5: de Llanos M, Ballescà JL, Gázquez C, Margarit E, Oliva R.
High frequency of gr/gr chromosome Y deletions in consecutive oligospermic ICSI candidates.
Hum Reprod. 2005 Jan;20(1):216-20.
4: Mengual L, Oriola J, Ascaso C, Ballescà JL, Oliva R.
An increased CAG repeat length in the androgen receptor gene in azoospermic ICSI candidates.
J Androl. 2003 Mar-Apr;24(2):279-84
3: Paracchini S, Stuppia L, Gatta V, Palka G, Moro E, Foresta C, Mengua L, Oliva R, Ballescà JL, Kremer JA, van Golde RJ, Tuerlings JH, Hargreave T, Ross A, Cooke H, Huellen K, Vogt PH, Tyler-Smith C.
Y-chromosomal DNA haplotypes in infertile European males carrying Y-microdeletions.
J Endocrinol Invest. 2000 Nov;23(10):671-6
2: de Yebra L, Ballescà JL, Vanrell JA, Bassas L, Oliva R.
Complete selective absence of protamine P2 in humans.
J Biol Chem. 1993 May 15;268(14):10553-7
1: Oliva R, Martínez-Heredia J, de Mateo S, Gázquez C, Oriola J, Estanyol JM, Guimerà M, Balasch J, Ballescà JL.
Proteomics of human spermatozoa, protamine content and assisted reproduction outcome.
Soc Reprod Fertil Suppl. 2007;65:527-30