A new study considers methadone to be the most appropriate non-addictive opioid drug to treat chronic pain

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Administrating methadone instead of morphine is he most indicated pharmacological treatment in the fight against chronic pain, according to a new article published in the Journal of Clinical Investigation –which counts on the participation of the experts Vicent Casadó, Estefania Moreno and Verònica Casado-Anguera, from the Molecular Neurobiology Research Group of the Faculty of Biology, the Institute of Biomedicine of the University of Barcelona (IBUB) and the Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED).

The new study, which describes the molecular action mechanism in cell and animal models brought by the therapeutical benefits of methadone, counts on the participation of the experts from the National Institute of Health, the University of Maryland, and the Massachusetts General Hospital (United States), among other institutions.   

The experts Vicent Casadó, Estefanía Moreno and Verònica Casadó-Anguera, from the Molecular Neurobiology Research Group of the Faculty of Biology, the IBUB and the CIBERNED.

Reference articles:

Cai, N. S.; Quiroz, C.; Bonaventura, J.; Bonifazi, A.; Cole, T. O.; Purks, J.; Billing, A. S.; Massey, E.; Wagner, M.; Wish, E. D.; Guitart, X.; Rea, W.; Lam, S.; Moreno, E.; Casadó-Anguera, V.; Greenblatt, A. D.; Jacobson, A. E.; Rice, K. C.; Casadó, V.; Newman, A. H.; Winkelman, J. W.; Michaelides, M.; Weintraub, E.; Volkow, N. D.; Belcher, A. M.; Ferré, S. «Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids», Journal of Clinical Investigation, 2019, 130: 2730-2744. Doi: 10.1172/JCI126912

Moreno, E.; Quiroz, C.; Rea, W.; Cai, N. S.; Mallol, J.; Cortés, A.; Lluís, C.; Canela, E. I.; Casadó, V.; Ferré, S. «Functional μ-opioid-galanin receptor heteromers in the ventral tegmental area». Journal of Neuroscience, 2017, 37(5): 1176-1186. Doi: 10.1523/JNEUROSCI.2442-16.2016

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