Our aim is to study lipid metabolism in the development of obesity-induced insulin resistance and type 2 diabetes. In vitro and in vivo mechanistic studies to find new approaches to combat obesity through the following research lines:
- Enhancing adipose tissue thermogenesis (CPT1A expression, lncRNAs).
- Central activation of brown adipose tissue and satiety (neuronal CPT1A’s role and new inhibitors).
- Adipose tissue in adults and children with obesity (childhood obesity and new biomarkers in obesity).
Funding in Process
- 2023 - 2024Unravelling the human brown adipose tissue secretome and its implication on obesity CIBEROBN Intramural (Coordinator: Jonatan Ruiz)
- 2023 - 2025Nuevos retos de investigación sobre plasticidad adiposa Redes de investigación. Spanish Ministry of Science and Innovation-MCIN (Coordinator: Francesc Villarroya)
- 2022 - presentCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN) CB06/03/0001. Instituto de Salud Carlos III (PI: Laura Herrero)
- 2021 - 2024Modulation of the adipose tissue and AgRP neurons’ lipid metabolism to counteract obesity and diabetes MCIN-AEI (PI: Laura Herrero / Dolors Serra)
Past Funding
- 2020 - 2022Unraveling the pathophysiology of adipose tissue of obese children through next-generation RNA sequencing (KIDSADIPOSEQ) CIBEROBN intramural project (OBN20PI03/2020) (Coordinator: Laura Herrero)
- 2019 - 2021Drug delivery targeting Brain CPT1: a novel nanomedicine-based approach to fight obesity and cancer (CONCORD) Japanese Medical Research Agency (AMED) & National Research Agency (AEI) (PI: Rosalía Rodríguez-Rodríguez)
- 2018 - 2020Next-generation RNA sequencing and single-cell RNAseq: novel opportunities for understanding human adipose tissue pathophysiology and obesity (ADIPOSEQ) CIBEROBN Intramural (PI: Francesc Villarroya)
- 2018 - 2019Analysis of the Inflammatory Profile in Childhood Onset Diabetes Sidra Internal Research Fund (IRF). Qatar Foundation (Meritxell Espino)
- 2018 - 2021Regulation of central and peripheral lipid metabolism to reduce food intake and obesity Spanish ministry of economy, industry and competitiveness (SAF2017-83813-C3-1-R) ((PI: Dolors Serra; Co-PI: Laura Herrero))
- 2017 - 2019Consolidated research groups. Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR). 2017 SGR 278 (PI: Dolors Serra)
- 2017 - 2019Identification of differential markers in morbid obese patients with different metabolic profile Universidad CEU San Pablo-Banco Santander (Martín Alcalá)
- 2017 - 2020Carnitine palmitoyltransferase 1-mediated strategies to activate brown fat and reduce food intake to fight against obesity. Fundació Marató TV3. (PI: Dolors Serra)
- 2015 - 2018Estudio de las carnitinas palmitoiltransferasas en hipotálamo como potenciales dianas para el control de la ingesta y el tratamiento de la obesidad Ministry of economy and competitiveness of Spain (SAF2014-52223-C2-1-R) (PI: Dolors Serra; Co-PI: Jordi García)
- 2015 - 2017Estudio de las carnitina palmitoiltransferasas en hipotálamo como potenciales dianas para el control de la ingesta y tratamiento de la obesidad. Ministry of economy and competitiveness of Spain. SAF2014-5223-C2-1-R (PI: Dolors Serra)
- 2014 - 2017Enhancing brown adipose tissue fat-burning power as a therapy against obesity-induced diabetes. Ministry of economy and competitiveness of Spain. SAF2013-45887-R (PI: Laura Herrero)
- 2014 - 2016Consolidated research groups. Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR). (2014 SGR 465; 2014-2016) (PI: Dolors Serra)
- 2014 - 2015Enhancing brown adipose tissue fat-burning power as a therapy against obesity-induced diabetes. L’Oréal-UNESCO Research Fellowship. (PI: Laura Herrero)
- 2013 - 2015Enhancing brown adipose tissue fat-burning power as a therapy against obesity-induced diabetes. European Foundation for the Study of Diabetes (EFSD) and Janssen Research Fellowship. (PI: Laura Herrero)
- 2013 - 2014Enhancing brown adipose tissue fat-burning power as a therapy against obesity-induced diabetes. European Foundation for the Study of Diabetes (EFSD)/Lilly Research Fellowship (PI: Laura Herrero)
- 2012 - 2014New strategies of fatty acid oxidation modulation for the treatment of obesity. Ref. SAF2011-30520-C02-01. MICINN (PI: Dolors Serra)
- 2012 - 2021Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) CB06/03/0001. Instituto de Salud Carlos III, Ministerio de Sanidad. (PI: Xavier Remesar / Dolors Serra)
- 2011 - 2013Fatty acid oxidation in the adipose tissue to revert obesity and type 2 diabetes. Ministry of Science and Innovation of Spain. Ref. SAF2010-20039. (PI: Laura Herrero)