2024
The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ cross-talk
Valdecantos MP, Ruiz L, Folgueras C, Rada P, Gomez B, Solas M, Hitos AB, Field J, Francisco V, Escalona-Garrido C, Zagmutt S, Calderón-Dominguez M, Mera P, García Martínez I, Maymó-Masip E, Grajales D, Alen R, Mora A, Sainz N, Vides-Urrestarazu I, Vilarrasa N, Arbones-Mainar JM, Valderrabano S, Zaragoza C, Moreno-Aliaga MJ, Aspichueta P, Fernandez-Veledo S, Vendrell J, Serra D, Herrero L, Schreiber R, Zechner R, Sabio G, Hornigold D, Rondinone CM, Jermutus L, Grimsby J, Valverde AM,
Nature Communications, 2024
Interleukin-16 is increased in obesity and alters adipogenesis and inflammation in vitro
Reyes-Farias M#, Fernández-García P#, Corrales P, González L, Soria-Gondek A, Martínez E, Pellitero S, Tarascó J, Moreno P, Sumoy L, Medina-Gómez G, Sánchez-Infantes D*, Herrero L*,
Frontiers in Endocrinology, 2024
Claudin-1 as a novel target gene induced in obesity and associated to inflammation, fibrosis and cell differentiation
Reyes-Farias M, Taxeras SD, González L, Cereijo R, Soria-Gondek A, Pellitero S, Tarascó J, Moreno P, Sumoy L, Galán M, Corrales P, Fernández P, Izquierdo A, Medina-Gómez G, Herrero L, Villarroya F, Sánchez-Infantes D,
Eur J Endocr, 2024
Applications of genome-editing technologies for Type 1 Diabetes
El Nahas R, Al-Aghbar MA, Herrero L, Van Panhuys N, Espino-Guarch M,
Int J Molecular Sciences, 2024
Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice
Ibeas K, Griñán-Ferré C, Romero MM, Sebastián D, Bastías-Pérez M, Gómez R, Soler-Vázquez MC, Zagmutt S, Pallás M, Castell M, Belsham DD, Mera P, Herrero L, Serra D,
Aging Cell, 2024
2023
Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice
Laiglesia LM, Escoté X, Sáinz N, Felix-Soriano E, Santamaria E, Collantes M, Fernández-Galilea M, Colón-Mesa I, Martínez-Fernández L, Quesada-López T, Quesada-Vázquez S, Rodríguez-Ortigosa C, Arbones-Mainar JM, Valverde AM, Martínez JA, Dalli J, Herrero L, Lorente-Cebrián S, Villarroya F, Moreno-Aliaga MJ,
Molecular Metabolism, 2023
Nanomedicine targeting brain lipid metabolism as a feasible approach for controlling energy balance
Garcia-Chica J, Paraiso WKD, Zagmutt S, Fosch A, Reguera AC, Alzina S, Sánchez-García L, Fukushima S, Toh K, Casals N, Serra D, Herrero L, Garcia J, Kinoh H, Kataoka K, Ariza X, Quader S, Rodríguez-Rodríguez R,
Biomaterials Science, 2023
Central regulation of brown fat thermogenesis in response to saturated or unsaturated long-chain fatty acids
Fosch A, Rodriguez-Garcia M, Miralpeix C, Zagmutt S, Larrañaga M, Reguera AC, Garcia-Chica J, Herrero L, Serra D, Casals N*, Rodriguez-Rodriguez R*,
International Journal of Molecular Sciences. 2023
To be or not to be a fat burner, that is the question for CPT1C in cancer cells
Fadó R, Zagmutt S, Herrero L, Muley H, Bi H, Rodríguez-Rodríguez R, Serra D, Casals N,
Cell Death & Disease. 2023
Ketohexokinase-C Mediates Global Protein Acetylation to Decrease Carnitine Palmitoyltransferase 1a Mediated Fatty Acid Oxidation
Helsley RN, Park S-H, Vekaria HJ, Sullivan PG, Conroy LR, Sun RC, Romero MM, Herrero L, Bons J, King C, Rose J, Meyer JG, Schilling B, Kahn CR, Softic S,
Journal of Hepatology, 2023
CPT1A in AgRP neurons is required for sex-dependent regulation of feeding and thirst
Zagmutt S, Mera P, González-García I, Ibeas K, Romero MM, Obri A, Martin B, Esteve-Codina A, Soler-Vázquez MC, Bastias-Pérez M, Cañes L, Augé E, Pelegri C, Vilaplana J, Ariza X, García J, Martinez-González J, Casals N, López M, Palmiter R, Sanz E, Quintana A, Herrero L, Serra D,
Biology of Sex Differences, 2023
3D bioprinted functional skeletal muscle models have potential applications for studies of muscle wasting in cancer cachexia
García-Lizarribar A, Villasante A, Lopez-Martin JA, Flandez M, Soler-Vázquez MC, Serra D, Herrero L, Sagrera A, Efeyan A, Samitier J,
Biomaterials Advances, 2023
Implantation of CPT1AM-expressing adipocytes reduces obesity and glucose intolerance in mice
Soler-Vázquez MC, Romero MM, Todorcevic M, Delgado K, Calatayud C, Benitez-Amaro A, La Chica Lhoëst MT, Mera P, Zagmutt S, Bastías-Pérez M, Ibeas K, Casals N, Escolà-Gil JC, Llorente-Cortés V, Consiglio A, Serra D, Herrero L,
Metabolic Engineering, 2023
Childhood obesity: implications on adipose tissue dynamics and metabolic health
Palacios I, Serra D, Jiménez-Chillarón J*, Herrero L*, Todorcevic M*,
Obesity Reviews, 2023
Experimental models to study adipose tissue in childhood obesity
Nieto B, Herrero L*, Todorčević M*,
BMI Journal, 2023
Adipose tissue dynamics: cellular and lipid turnover in health and disease
Palacios I, Serra D, Jiménez-Chillarón J*, Herrero L*, Todorcevic M*,
Nutrients, 2023
Effects of intermittent fasting on metabolism, cognitive function, and aging
Cubeles-Juberias E, Herrero L*, Romero MM*,
BMI Journal, 2023
Inhibition of YTHDF1 by salvianolic acid overcomes gluten induced intestinal inflammation
Olazagoitia-Garmendia A, Rojas-Marquez H, Romero MM, Ruiz P, Agirre-Lizaso A, Chen Y, Perugorria MJ, Herrero L, Serra D, Luo C, Bujanda L, He C, Castellanos-Rubio A,
Gut, 2023
In vivo sensitization to gliadin by oral administration
Romero MM, Serra D, Castellanos-Rubio A*, Herrero L*,
Methods in Cell Biology, 2023
2022
A galactooligosaccharide product decreases the rotavirus infection in suckling rats
Massot-Cladera M, Rigo-Adrover MM, Herrero L, Franch A, Castell M, Vulevic J, Pérez-Cano FJ, Rodríguez Lagunas MJ,
Cells, 2022
Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells
Olazagoitia-Garmendia A, Zhang L, Mera P, Godbout JK, Sebastian-delaCruz M, Garcia-Santisteban I, Mendoza LM, Huerta A, Irastorza I, Bhagat G, Green PH, Herrero L, Serra D, Rodriguez JA, Verdu EF, He C, Bilbao JR, Castellanos-Rubio A,
Gut, 2022
Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function
da Silva Lima N, Fondevila MF, Nóvoa E, Buque X, Gallet S, González-Rellan MJ, Fernandez U, Loyens A, Garcia-Vence M, Chantada-Vazquez MP, Bravo SB, Marañon P, Escudero A, Leiva M, Guallar D, Fidalgo M, Gomes P, Claret M, Sabio G, Varela-Rey M, Delgado TC, López M, Diéguez C, Herrero L, Serra D, Schwaninger M, Martinez-Chantar ML, Prevot V, Gallego R, Romero-Gomez M, Garcia-Monzon C, Gonzalez-Rodriguez A, Aspichueta P, Nogueiras R,
Journal of Hepatology, 2022
Angiocrine polyamines production regulates adiposity
Monelli E, Villacampa P, Zabala-Letona A, Martinez-Romero A, Llena J, Beiroa D, Gouveia L, Chivite I, Zagmutt S, Gama-Perez P, Osorio-Conles O, Muixi L, Martinez-Gonzalez A, Castillo SD, Martín-Martín N, Castel P, Valcarcel-Jimenez L, Garcia-Gonzalez I, Villena JA, Fernandez-Ruiz S, Serra D, Herrero L, Benedito R, Garcia-Roves PM, Vidal J, Cohen P, Nogueiras R, Claret M, Carracedo A, Graupera M,
Nature Metabolsim, 2022
Inhibition of CPT1A in hepatic stellate cells protects against fibrosis
Fondevila MF, Fernandez U, Heras V, Parracho T, Gonzalez-Rellan MJ, Novoa E, Porteiro B, Lima N, Iglesias C, Filliol AA, Senra A, Delgado TC, Woodhoo A, Herrero L, Serra A, Prevot V, Schwaninger M, Lopez M, Dieguez C, Millet O, Mato JM, Cubero FJ, Varela-Rey M, Iruzubieta P, Crespo J, Martinez-Chantar ML, Schwabe RF, Nogueiras R,
Journal of Hepatology, 2022
Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics
Barahona I, Rada P, Calero-Pérez S, Grillo-Risco R, Pereira L, Soler-Vázquez MC, LaIglesia LM, Moreno-Aliaga MJ, Herrero L, Serra D, García-Monzon C, González-Rodriguez A, Balsinde J, García-García F, Valdecantos MP, Valverde AM,
Cell Death & Differentiation, 2022
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Ramino S, Miró-Blanch J, Oemer G, Duran X, Sánchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernandez-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM,
Redox Biology, 2022
Role of long non-coding RNAs in adipose tissue metabolism and associated pathologies
Corral A, Alcala M, Duran-Ruiz MC, Arroba AI, Ponce-Gonzalez JG, Todorčević M, Serra D, Calderon-Dominguez M*, Herrero L* (*co-corresponding authors),
Biochemical Pharmacology, 2022
In vivo sensitization to gliadin by oral administration
Romero MM, Serra D, Castellanos-Rubio A*, Herrero L*,
Methods in Cell Biology, 2022
Reduction of obesity and insulin resistance through dual targeting of VAT and BAT by a novel combination of metabolic cofactors in diet-induced obese mice
Quesada-Vázquez S, Antolín A, Colom-Pellicer M, Aragonès G, Herrero L, Del Bas JM, Caimari A, Escoté X,
International Journal of Molecular Sciences, 2022
2021
White adipose tissue-infiltrated CD11b+ myeloid cells are a source of S100A4, a new potential marker of hepatic damage
Reyes M#, González L#, Ibeas K#, Cereijo R, Taxerås SD, Pellitero S, Martínez E, Tarascó J, Moreno P, Malagón P, Higueras C, Soria A, Puig-Domingo M, Villarroya F, Serra D, Herrero L*, Sánchez-Infantes D* (#equal contribution; *co-corresponding authors),
European Journal of Endocrinology, 2021
Renal tubule Cpt1a overexpression mitigates kidney fibrosis by restoring mitochondrial homeostasis
Miguel V, Tituaña J, Herrero JI, Herrero L, Serra D, Cuevas P, Barbas C, Rodríguez Puyol D, Márquez-Exposito L, Ruiz-Ortega M, Castillo C, Sheng X, Susztak K, Ruiz-Canela M, Salas-Salvadó J, Hu FB, Martínez Gonzalez MA, Ortega S, Ramos R, Lamas S,
JCI, 2021
Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma
Ruiz-Pérez, MV, Sainero-Alcolado L, Oliynyk G, Matuschek I, Balboni N, Ubhayasekera SJKA, Snaebjornsson MT, Makowski K, Aaltonen K, Bexell D, Serra D, Nilsson R, Bergquist J, Schulze A, Arsenian-Henriksson M,
iScience, 2021
Calorie restriction and SIRT1 overexpression induce different gene expression profiles in white adipose tissue in association with metabolic improvement
Pardo R, Velilla M, Herrero L, Cervela L, Ribeiro ML, Simó R, Villena J,
Molecular Nutrition & Food Research, 2021
Effects of lifestyle intervention in tissue-specific lipidomic profile of formerly obese mice
Dahdah N, Gonzalez-Franquesa A, Samino S, Gama-Perez P, Herrero L, Yanes O, Perales JC, Malagon MM, Garcia-Roves PM,
International Journal of Molecular Sciences, 2021
Hypothalamus-skeletal muscle crosstalk during exercise and its role in metabolism modulation
Ibeas K, Herrero L, Mera P*, Serra D* (*co-corresponding authors),
Biochemical Pharmacology, 2021
Infusion of phagocytic macrophages overexpressing CPT1a ameliorates kidney fibrosis in the UUO model
Calle P, Játiva S, Torrico S, Muñoz A, García M, Sola A, Serra D, Mera P, Herrero L, Hotter G,
Cells, 2021
Poly-ion complex micelle effectively delivers CoA-conjugated CPT1A inhibitors to modulate lipid metabolism in brain cells
Paraiso WKD, Garcia-Chica J, Ariza X, Zagmutt S, Fukushima S, Garcia J, Mochida Y, Serra D, Herrero L, Kinoh H, Casals N, Kataoka K, Rodríguez-Rodríguez R, Quader S,
Biomaterials Science, 2021
Adipose tissue dysfunction in obesity and aging
Reyes M, Fos-Domenech J, Serra D, Herrero L*, Sánchez-Infantes D* (*co-corresponding authors),
Biochemical Pharmacology, 2021
2020
Dietary options for rodents in the study of obesity
Bastías-Pérez M, Serra D, Herrero L,
Nutrients, 2020
Moderate SIRT1 overexpression protects against inflammation of brown adipose tissue
Escalona-Garrido C, Vázquez P, Mera P, Zagmutt S, García-Casarrubios E, Montero-Pedrazuela A, Rey-Stolle F, Guadaño-Ferraz A, Rupérez FJ, Serra D, Herrero L, Obregón MJ, Valverde AM,
Molecular Metabolism, 2020
Inhibitors of lipogenic enzymes as a potential therapy against cancer
Montesdeoca N, López M, Ariza X, Herrero L*, Makowski K* (*co-corresponding authors),
FASEB Journal, 2020
Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
Weber M*, Mera P*, Casas F, Salvador J, Rodríguez A, Alonso S, Sebastián D, Soler-Vázquez MC, Montironi C, Recalde S, Fucho R, Calderon-Dominguez M, Mir JF, Bartrons R, Escola-Gil JC, Sánchez-Infantes D, Zorzano A, Llorente-Cortes V, Casals N, Valentí V, Frühbeck G, Herrero L, Serra D (*co-first authors),
FASEB Journal, 2020
An overview of nanomedicines for neuron targeting
Garcia-Chica J, Paraiso WK, Tanabe S, Serra D, Herrero L, Casals N, Garcia J, Ariza X, Quader S, Rodriguez-Rodriguez R,
Nanomedicine, 2020
The role of epigenetics in the development of obesity
Obri A, Serra D, Herrero L, Mera P,
Biochemical Pharmacology, 2020
Low-density lipoprotein receptor-related protein 1 deficiency in cardiomyocytes reduces susceptibility to insulin resistance and obesity
Benitez-Amaro A, Revuelta-López E, Bornachea O, Cedo L, Vea A, Herrero L, Roglans N, Soler-Botija C, de Gonzalo-Calvo D, Nasarre L, Camino-López S, García JE, Mato E, Blanco-Vaca F, Bayes-Genis A, Sebastian D, Laguna JC, Serra D, Zorzano A, Escola-Gil JC, Llorente-Cortes V,
Metabolism-Clinical and Experimental, 2020
Use of infrared thermography to estimate brown fat activation after a cooling protocol in patients with severe obesity that underwent bariatric surgery
Piquer-Garcia I, Cereijo R, Corral-Pérez J, Pellitero S, Martínez E, Taxerås SD, Tarascó J, Moreno P, Balibrea J, Puig-Domingo M, Serra D, Herrero L, Jiménez-Pavón D, Lerin C, Villarroya F, Sánchez-Infantes D,
Obesity surgery, 2020
Impact of adaptive thermogenesis in mice on the treatment of obesity
Bastías-Pérez M, Zagmutt S, Soler-Vázquez MC, Serra D*, Mera P*, Herrero L* (*co-corresponding authors),
Cells, 2020. 9, 316
2019
Dietary sugars alter hepatic fatty acid oxidation via transcriptional and post-translational modifications of mitochondrial proteins
Softic S, Meyer JG, Wang G-X, Gupta MK, Batista TM, Lauritzen HPMM, Fujisaka S, Serra D, Herrero L, Willoughby J, Fitzgerald K, Ilkayeva O, Newgard CB, Gibson BW, Schilling B, Cohen DE, Kahn CR.,
Cell Metabolism, 2019. 30(4): 735-753.
Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice
Miralpeix C, Fosch A, Casas J, Baena M, Herrero L, Serra D, Rodríguez-Rodríguez R, Casals N,
Journal of Lipid Research, 2019. 60:1260-69.
CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity
Rodríguez-Rodríguez R, Miralpeix C, Fosch A, Pozo M, Calderón-Domínguez, M, Perpinyà X, Vellvehí M, López M, Herrero L, Serra D, Casals N,
Molecular Metabolism, 2019. 19:75-85
Mechanisms of impaired brown adipose tissue recruitment in obesity
Alcalá M, Calderon-Dominguez M, Serra D*, Herrero L*, Viana M* (* co-corresponding authors),
Frontiers in Physiology-Integrative Physiology. 2019. 10: 94
2018
CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity
Rodríguez-Rodríguez R, Miralpeix C, Fosch A, Pozo M, Calderón-Domínguez M, Perpinyà X, Vellvehí M, López M, Herrero L, Serra D, Casals N.,
Molecular Metabolism, 2018. pii: S2212-8778(18)30935-9.
New approaches targeting brown adipose tissue transplantation as a therapy in obesity
Soler-Vázquez MC, Mera P, Zagmutt S, Serra D, Herrero L,
Biochemical Pharmacology, 2018. 155: 346-355.
Targeting AgRP neurons to maintain energy balance: lessons from animal models
Zagmutt S, Mera P, Soler-Vázquez MC, Herrero L, Serra D,
Biochemical Pharmacology, 2018. 155:224-232.
Ghrelin causes a decline in GABA release by reducing fatty acid oxidation in cortex
Mir JF, Zagmutt S, Lichtenstein MP, García-Villoria J, Weber M, Gracia A, Fabriàs G, Casas J, López M, Casals N, Ribes A, Suñol C, Herrero L, Serra D,
Molecular Neurobiology, 2018. doi: 10.1007/s12035-018-0921-3
The BACE1 product sAPPbeta induces ER stress and inflammation and impairs insulin signaling
Botteri G, Salvadó L, Gumà A, Lee Hamilton D, Meakin PJ, Montagut G, Ashford MLJ, Ceperuelo-Mallafré V, Fernández-Veledo S, Vendrell J, Calderón-Dominguez M, Serra D, Herrero L, Pizarro J, Barroso E, Palomer X, Vázquez-Carrera M,
Metabolism, Clinical and Experimental, 2018; pii: S0026-0495(18)30071-4
2017
Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice.
Alcalá M, Calderon-Dominguez M, Bustos E, Ramos P, Casals N, Serra D, Viana M, Herrero L.,
Sci Rep. 7(1):16082.
Ceramides and mitochondrial fatty acid oxidation in obesity
Fucho R, Casals N, Serra D*, Herrero L* (* corresponding authors). Review,
FASEB Journal. 2017. 31:1-10
(-)-UB006: a new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects
Makowski K, Mir JF, Mera P, Ariza X, Asins G, Hegardt FG, Herrero L, García J*, Serra D* (*Corresponding authors),
Eur J Med Chem. 2017. 131: 207-221
Brown Adipose Tissue Bioenergetics: A New Methodological Approach
Calderon-Dominguez M, Alcalá M, Sebastián D, Zorzano A, Viana M, Serra D, Herrero L,
Advanced Science. 2017. 4(4):1600274
Hypothalamic regulation of liver and muscle nutrient partitioning by brain-specific carnitine palmitoyltransferase 1C (CPT1C) in male mice
Pozo M, Rodríguez-Rodríguez R, Ramírez S, Seoane-Collazo P, López M, Serra D, Herrero L, Casals N,
Endocrinology. 2017 Jul 1;158(7):2226-2238.
Short-term vitamin E treatment impairs reactive oxygen species signaling required for adipose tissue expansion, resulting in fatty liver and insulin resistance in obese mice.
Alcala M, Calderon-Dominguez M, Serra D, Herrero L, Ramos MP, Viana M.,
PLoS One. 2017 Oct 13;12(10):e0186579.
HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism.
Du W, Zhang L, Brett-Morris A, Aguila B, Kerner J, Hoppel CL, Puchowicz M, Serra D, Herrero L, Rini BI, Campbell S, Welford SM.,
Nat Commun. Nov 24;8(1):1769.
2016
Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes
García-Casarrubios E, Moura C, Arroba AI, Pescador N, Calderon-Dominguez M, Garcia L, Herrero L, Serra D, Cadenas S, Reis F, Carvalho E, Obregon MJ, Valverde AM,
Biochim Biophys Acta. 2016. 1861:1929-1941
Carnitine palmitoyltransferase 1C: from Cognition to Cancer
Casals N*, Zammit V*, Herrero L, Fadó R, Rodríguez-Rodríguez R, Serra D,
(*corresponding authors) Review. Progress in Lipid Research. 2016. 61: 134-148.
Carnitine palmitoyltransferase 1 increases lipolysis, UCP1 protein expression and mitochondrial activity in brown adipocytes
Calderon-Dominguez M, Sebastián D, Fucho R, Weber M, Mir JF, García-Casarrubios E, Obregón MJ, Zorzano A, Valverde AM, Serra D, Herrero L,
PlosOne. 2016. 11(7): e0159399
Fatty Acid Metabolism and the Basis of Brown Adipose Tissue Function
Calderon-Dominguez M, Mir JF, Fucho R, Weber M, Serra D, Herrero L,
Review. Adipocyte. 5(2): 98-118, 2016.
2015
Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells
Veigel D, Wagner R, Stübiger G, Wuczkowski M, Filipits M, Horvat R, Benhamú B, López-Rodríguez ML, Leisser A, Valent P, Grusch M, Hegardt FG, García J, Serra D, Auersperg N, Colomer R, Grunt TW,
Int J Cancer. 2015, 136(9):2078-90
Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation
Malandrino MI, Fucho R, Weber M, Calderon-Dominguez M, Mir JF, Valcarcel L, Escoté X, Gómez-Serrano M, Peral B, Salvadó L, Casals N, Villarroya F, Vázquez-Carrera M, Vendrell JJ, Serra D, Herrero L,
Am J Physiol Endocrinol Metab. 2015. 308 (9): E756-E769
Altered circadian rhythm and metabolic gene profile in rats subjected to advanced light phase shifts
Herrero L, Valcarcel L, Chris N, Diez A, Cambras T*, Serra D*,
(*corresponding authors) Plos One, 2015. 10(4):e0122570
Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes
Valdecantos MP, Prieto-Hontoria PL, Pardo V, Módol T, Santamaría B, Weber M, Herrero L, Serra D, Muntané J, Cuadrado A, Moreno-Aliaga MJ, Martínez JA, Valverde AM,
Free Radical Biology & Medicine, 2015. 84:263-278
Vitamin E-mediated oxidative stress blockade reduces adipose tissue fibrosis and improves lipid metabolism and insulin sensitivity
Alcalá M, Sánchez-Vera I, Sevillano J, Ramos MP, Herrero L, Serra D, Viana M,
Obesity, 2015. 23(8): 1598-1606
Estratègies de modulació de l’oxidació d’àcids grassos com a tractament per combatre l’obesitat
Herrero L, Mir JF, Weber M, Fucho R, Calderón M, Serra D,
Review. Societat Catalana de Química, 2015: 16-24
2014
Long-term increased carnitine palmitoyltransferase 1A expression in ventromedial hypotalamus causes hyperphagia and alters the hypothalamic lipidomic profile
Mera P#, Mir JF#, Fabriàs G, Casas J, Costa ASH, Malandrino MI, Fernández-López JA, Remesar X, Gao S, Chohnan S, Rodríguez-Peña MS, Petry H, Asins G, Hegardt FG, Herrero L*, Serra D*,
(#equal contribution; *corresponding authors) Plos One, 2014, 9(5): e97195
Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance
Contreras C, González-García I, Martínez-Sánchez N, Seoane-Collazo P, Jacas J, Morgan DA, Serra D, Gallego R, Gonzalez F, Casals N, Nogueiras R, Rahmouni K, Diéguez C, López M,
Cell Rep. 2014,9(1):366-77
Enhancing hepatic fatty acid oxidation as a strategy for reversing metabolic disorders programmed by maternal undernutrition during gestation
Torrens JM, Orellana-Gavaldà JM, Palou M, Sánchez J, Herrero L, Picó C, Serra D, Palou A,
Cell. Physiol. Biochem, 2014, 33(5): 1498-1515
2013
Mitochondrial fatty acid oxidation in obesity.
Serra D, Mera P, Malandrino MI, Mir JF, Herrero L.,
Antioxid Redox Signal. 2013 Jul 20;19(3):269-84.
PMID: 22900819
Pubmed
Hypothalamic ceramide levels regulated by CPT1C mediate the orexigenic effect of ghrelin.
Ramírez S, Martins L, Jacas J, Carrasco P, Pozo M, Clotet J, Serra D, Hegardt FG, Diéguez C, López M, Casals N,
Diabetes. 2013 Jul;62(7):2329-37
PMID: 23493572
Pubmed
Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity.
Makowski K, Mera P, Paredes D, Herrero L, Ariza X, Asins G, Hegardt FG, García J, Serra D,
Chirality. 2013 May;25(5):281-7. Mol Biol Rep. 2012 Apr;39(4):4777-85
PMID: 23620264
Pubmed
Important role of ventromedial hypothalamic carnitine palmitoyltransferase-1a in the control of food intake.
Gao S, Serra D, Keung W, Hegardt FG, Lopaschuk GD,
Am J Physiol Endocrinol Metab. 2013 Aug 1;305(3):E336-47
PMID: 23736540
Pubmed
New strategies in the modulation of fatty acid oxidation as a treatment for obesity
Herrero L, Mera P, Orellana-Gavaldà JM, Gurunathan C, Malandrino MI, Mir JF, Makowski K, Pozo M, Arasa MM, Ariza X, Asins G, García J, Hegardt FG, Serra D,
e-book: Recent Advances in Pharmaceutical Sciences III. 77-89 ISBN: 978-81-7895-605-3. 2013
Convenient synthesis of C75, an inhibitor of FAS and CPT1
Sánchez C, Makowski K, Mera P, Farràs J, Nicolás E, Herrero L, Asins G, Serra D, Hegardt FG, Ariza X, Garcia J,
RSC Advances. 3 (18): 6564-6571. 2013
2012
Cornelia de Lange syndrome with NIPBL mutation and mosaic Turner syndrome in the same individual.
Wierzba J, Gil-Rodríguez MC, Polucha A, Puisac B, Arnedo M, Teresa-Rodrigo ME, Winnicka D, Hegardt FG, Ramos FJ, Limon J, Pié J. BMC Med Genet.,
2012 Jun 7;13(1):43
PMID: 22676896
Pubmed
Ceramide levels regulated by carnitine palmitoyl transferase 1C control dendritic spine maturation and cognition.
Carrasco P, Sahun I, McDonald J, Ramirez S, Jacas J, Gratacós E, Sierra AY, Serra D, Herrero L, Acker-Palmer A, Hegardt FG, Dierssen M, Casals N. J Biol Chem,
2012 Jun 15;287(25):21224-32.
PMID: 22539351
Pubmed
Characterization of splice variants of the genes encoding human mitochondrial HMG-CoA lyase and HMG-CoA synthase, the main enzymes of the ketogenesis pathway.
Puisac B, Ramos M, Arnedo M, Menao S, Gil-Rodríguez MC, Teresa-Rodrigo ME, Pié A, de Karam JC, Wesselink JJ, Giménez I, Ramos FJ, Casals N, Gómez-Puertas P, Hegardt FG, Pié J,
Mol Biol Rep. 2012 Apr;39(4):4777-85
PMID: 21952825
Pubmed
2011
Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding.
Gao S, Zhu G, Gao X, Wu D, Carrasco P, Casals N, Hegardt FG, Moran TH, Lopaschuk GD,
Natl Acad Sci U S A. 2011 Jun 7;108(23):9691-6.
PMID: 21593415
Pubmed
Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a.
Gao S, Keung W, Serra D, Wang W, Carrasco P, Casals N, Hegardt FG, Moran TH, Lopaschuk GD,
Am J Physiol Regul Integr Comp Physiol. 2011 Jul;301(1):R209-17.
PMID: 21508288
Pubmed
Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation.
Orellana-Gavaldà JM, Herrero L, Malandrino MI, Pañeda A, Sol Rodríguez-Peña M, Petry H, Asins G, Van Deventer S, Hegardt FG, Serra D. Hepatology.,
2011 Mar;53(3):821-32.
PMID: 21319201
Pubmed
2010
Preparation of α-labeled aldehydes by base-catalyzed exchange reactions.
Ariza X, Asins G, Garcia J, Hegardt FG, Makowski K, Serra D, Velasco X,
J Labelled Compounds and Radiopharmaceuticals. 2010 June 30;53(8):556-8.
Mutations and variants in the cohesion factor genes NIPBL, SMC1A, and SMC3 in a cohort of 30 unrelated patients with Cornelia de Lange syndrome.
Pié J, Gil-Rodríguez MC, Ciero M, López-Viñas E, Ribate MP, Arnedo M, Deardorff MA, Puisac B, Legarreta J, de Karam JC, Rubio E, Bueno I, Baldellou A, Calvo MT, Casals N, Olivares JL, Losada A, Hegardt FG, Krantz ID, Gómez-Puertas P, Ramos FJ.,
Am J Med Genet A. 2010 Apr;152A(4):924-9.
PMID: 20358602
Pubmed
Inflammation and adipose tissue macrophages in lipodystrophic mice.
Herrero L, Shapiro H, Nayer A, Lee J, Shoelson SE,
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):240-5.
PMID: 20007767
Pubmed
2009
Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells.
Sebastián D, Guitart M, García-Martínez C, Mauvezin C, Orellana-Gavaldà JM, Serra D, Gómez-Foix AM, Hegardt FG, Asins G.,
J Lipid Res. 2009 Sep;50(9):1789-99.
PMID: 19429947
Pubmed
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control.
Noland RC, Koves TR, Seiler SE, Lum H, Lust RM, Ilkayeva O, Stevens RD, Hegardt FG, Muoio DM,
J Biol Chem. 2009 Aug 21;284(34):22840-52.
PMID: 19553674
Pubmed
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters.
Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D,
Nat Med. 2009 Aug;15(8):930-9.
PMID: 19633656
Pubmed
Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria.
Menao S, López-Viñas E, Mir C, Puisac B, Gratacós E, Arnedo M, Carrasco P, Moreno S, Ramos M, Gil MC, Pié A, Ribes A, Pérez-Cerda C, Ugarte M, Clayton PT, Korman SH, Serra D, Asins G, Ramos FJ, Gómez-Puertas P, Hegardt FG, Casals N, Pié J,
Hum Mutat. 2009 Mar;30(3):E520-9.
PMID: 19177531
Pubmed
C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight.
Mera P, Bentebibel A, López-Viñas E, Cordente AG, Gurunathan C, Sebastián D, Vázquez I, Herrero L, Ariza X, Gómez-Puertas P, Asins G, Serra D, García J, Hegardt FG,
Biochem Pharmacol. 2009 Mar 15;77(6):1084-95.
PMID: 19094968
Pubmed