Medicinal Chemistry for Unmet Medical Needs
Department of Pharmacology, Toxicology and Therapeutic Chemistry
Faculty of Pharmacy and Food Sciences, UB
Carmen Escolano Mirón
ORCID ID: 0000-0002-9117-8239
Tel +34 934024540
https://www.ub.edu/medicinalchemistrypharmacology/research-group/dr-carmen-escolano/
Principal investigator: • Carmen Escolano Mirón
PhD student: • Fernando Romero Becerra • Joel Muixi Feliu
Current
Research
Our research group, based in the Unit of Medicinal Chemistry at the Faculty of Pharmacy and Food Sciences, is well equipped for all aspects of Medicinal Chemistry. Our team has a multidisciplinary character and is aimed to face projects within chemistry and biology. We are involved in the design and synthesis of organic entities to be used as pharmacological tools for the discovery of molecular mechanisms of action. We are also developing new chemical entities that face health problems with high social impact in unmet medical needs such as cancer (glioblastoma) and neurodegenerative diseases (Alzheimer Disease, AD).
Our projects are multidisciplinary an involve different institutions and excellent professionals.
Additionally, we regularly collaborate with different academic groups that requests new chemical entities to support/develop their projects. Finally, we have a long tradition providing a wide range of services to different pharmaceutical companies and biotechs, e.g. synthesis of new products; identification, isolation and synthesis of impurities, etc.
Selected
Publications
Bagán, A.; López-Ruiz, A.; Abás, S.; Ruiz-Cantero, M. C.; Vasilopoulou, F.; Taboada-Jara, T.; Griñán-Ferré, C.; Pallàs, M.; Muguruza, C.; Diez-Alarcia, R.; Callado, L. F.; Entrena, J. M.; Cobos, E. J.; Pérez, B.; Morales-García, J. A.; Molins, E.; De Jonghe, S.; Daelemans, D.; Brea, J.; Val, C.; Loza, M. I.; Hernández-Hernández, E.; García-Sevilla, J. A.; García-Fuster, M. J.; Díaz, C.; Fernández-Godino, R.; Genilloud, O.; Beljkaš, M.; Oljačić, S.; Nikolic, K.; Escolano, C. Discovery of (3-Phenylcarbamoyl-3,4-Dihydro-2 H -Pyrrol-2-Yl)Phosphonates as Imidazoline I2 Receptor Ligands with Anti-Alzheimer and Analgesic Properties. J. Med. Chem. 2025, 68 (3), 2551–2573. https://doi.org/10.1021/acs.jmedchem.4c01644.
Bagán, A.; Abás, S.; Palà-Pujades, J.; Irisarri, A.; Griñán-Ferré, C.; Pallàs, M.; Muneta-Arrate, I.; Muguruza, C.; Callado, L. F.; Pérez, B.; Molins, E.; Morales-García, J. A.; Escolano, C. Exploring the reactivity of bicyclic α-iminophosphonates to access new imidazoline I2 receptor ligands. Bioorganic Chemistry, 2024, 142, 106935. https://doi.org/10.1016/j.bioorg.2023.106935
Bagán, A.; Rodriguez-Arévalo, S.; Taboada-Jara, T.; Griñán-Ferré, C.; Pallàs, M.; Brocos-Mosquera, I.; Callado, L. F.; Morales-García, J. A.; Pérez, B.; Diaz, C.; Fernández-Godino, R.; Genilloud, O.; Beljkas, M.; Oljacic, S.; Nikolic, K.; Escolano, C. Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease, Pharmaceutics 2023, 15, 2381. Pharmaceutics | Free Full-Text | Preclinical Evaluation of an Imidazole-Linked Heterocycle for Alzheimer’s Disease (mdpi.com)
Rodriguez-Arévalo, S.; Bagán, A.; Griñán-Ferré, C.; Vasilopoulou, F.; Pallàs, M.; Brocos-Mosquera, I.; Callado, L.F.; Loza, M.I.; Martínez, A.L.; Brea, J.; Pérez, B.; Molins, E. De Jonghe, S.; Daelemans, D.; Radan, M.; Djikic, T.; Nikolic, K.; Hernández-Hernández, E.; García-Fuster, M. J.; García-Sevilla, J. A.; Escolano, C. Benzofuranyl-2-imidazoles as Imidazoline I2 Receptor Ligands for Alzheimer’s Disease. Eur. J. Med. Chem. 2021, 222, 113540. Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer’s disease (sciencedirectassets.com)
Abás, S.; Rodríguez-Arévalo, S.; Bagán, A.; Griñán-Ferré, C.; Vasilopoulou, F.; Brocos-Mosquera, I.; Muguruza, C.; Pérez, B.; Molins, E.; Luque, F.J.; et al. Bicyclic a-iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease. J. Med. Chem. 2020, 7, 3610–3633. Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease – PubMed (nih.gov)
Selected
Publications
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Author
Identification
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