Research Lines
Enteric Virus Lab
Research Lines
Molecular virology of Hepatitis A and E viruses
The group develops cell culture models to investigate the molecular basis of the interaction between enteric hepatitis viruses (A and E) and the host. Their aim is to better understand the mechanisms of pathogenesis. This knowledge is then applied to enhance viral replication and antigen production in vitro, support the development of novel vaccine prototypes, and identify potential therapeutic targets.
Molecular virology of astroviruses
Human astroviruses are divided into three genetically distinct groups: classic astroviruses, MLB astroviruses, and VA astroviruses.
Although traditionally considered agents causing gastroenteritis, they have also been associated with more severe symptoms, with infections spreading to the central nervous system especially in immunocompromised subjects. The group uses human organoids to understand the molecular basis of extra-intestinal dissemination and neurotropism.
Molecular epidemiology of viruses: quantification, NGS and phylogenetic studies
The group works on designing and optimizing new methods for the detection, quantification, and characterization of viral targets of interest, with the aim of contributing to early warning, outbreak control and conducting wastewater-based epidemiology studies. The viral targets include hepatitis and gastroenteritis viruses, SARS-CoV-2, enteroviruses, influenza viruses, respiratory syncytial virus, and monkeypox virus, as well as any other emerging virus.
Virological studies for the pharmaceutical sector
The group has extensive experience in transferring knowledge to the pharmaceutical sector. Over the years, they have carried out projects focused on analyzing virological safety during the manufacturing processes of pharmaceuticals, cosmetics, and other reagents. Additionally, they provide systems for viral antigen production and the development of novel vaccine candidates.
Virological safety of food and water: SAVCA Lab
Since 2019, the group is offering analytical services for the detection and quantification of viruses in samples of interest in the food chain and water cycle. They also provide advice on virological safety in the food chain. Additionally, the group focuses on the development of molecular methods to estimate the occurrence and quantification of infectious viruses in contaminated samples, to be applied in the field of risk assessment.
Environmental monitoring of emerging niruses and Wastewater-Based Epidemiology (WBE)
The group conducts environmental virology studies to monitor the circulation of emerging viruses. Through the analysis of viruses in wastewater, WBE enhances the surveillance of pathogens of public health interest by providing data on their geographical and temporal evolution and anticipating the detection and emergence of new pathogens.
