We are interested in discovering bioactive molecules (chemical probes) as a means to validate new points of pharmacological intervention. We aim to expand the so-called druggable genome by targeting so-far unexploited sites that elicit a biological response through non-standard mechanisms of action, such as conformational trapping, stabilisation of protein-protein complexes or allosterism.

To achieve this objective we employ a multi-disciplinary and question-driven approach that combines computational, biophysical and biological techniques. We are particularly strong in computer-aided drug design and develop computational approaches that enable us to tackle such novel and difficult targets with confidence. More…


Xavier Barril

 Xavier Barril


ICREA Research Professor

University of Barcelona