We are interested in discovering bioactive molecules (chemical probes) as a means to validate new points of pharmacological intervention. We aim to expand the so-called druggable genome by targeting so-far unexploited sites that elicit a biological response through non-standard mechanisms of action, such as conformational trapping, stabilisation of protein-protein complexes or allosterism.

To achieve this objective we employ a multi-disciplinary and question-driven approach that combines computational, biophysical and biological techniques. We are particularly strong in computer-aided drug design and develop computational approaches that enable us to tackle such novel and difficult targets with confidence. More…


Xavier Barril

 Xavier Barril


ICREA Research Professor

University of Barcelona



Institutions, Funding & Collaborators