Last week the members of the group presented their research at the Targeted Protein Degradation IRB Conference in Barcelona. Patricia, Alejandra, Roger and Andrea presented their recent results at the conference’s poster session. Jordi Juarez gave an amazing short talk on the cooperativity effects in the drug-dependent degradation of the Cereblon neosubstrate CK1 alpha.  On the […]

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The last 17th of September Carles attended to the Discovery on Target conference held on Boston, and he gave a talk on the Protein degradation session entitled ‘Drugging the Fbw7 E3 Ligase with a Combined Computational and Fragment-Based Approach’.

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From the 2nd to the 6th of September the XXV EFMC International Symposium on Medicinal Chemistry took place. This biennial symposium is key in the field of Medicinal Chemistry and attracts traditionally around 1200 participants, from industry and academia. Carles Galdeano participated there giving a talk entitled “Drugging the Fbw7 E3 Ligase with a Combined Computational […]

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From the 4th to the 6th of July the RICT 2018 conference was held in Strasbourg, which was devoted to “Interfacing Chemical Biology and Drug Discovery”. Míriam presented a poster entitled “Drugging Challenging E3 Ligases: A Novel Multidisciplinary Approach to Identify Small-Molecules that Bind Fbw7”. 

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On the 4th of May Ubiquitin Symposium&Friends took place in the Research Institute of Molecular Pathology in Vienna Biocenter. It was a great opportunity to discuss the state-of-the-art in the world of ubiquitin protein. Míriam presented a poster entitled “A Multidisciplinary Approach to Identify Small-Molecules Targeting the Fbw7 E3 Ligase”.

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Carles Galdeano has participated in the identification of a new therapeutic target for diseases caused by lack of oxygen. This work has been recently published in the journal Nature Communications (http://www.nature.com/articles/ncomms13312).   Link to the UB press release: http://www.ub.edu/web/ub/en/menu_eines/noticies/2016/11/027.html Link to the press: http://www.lavanguardia.com/vida/20161115/411882366948/crean-una-molecula-para-tratar-enfermedades-causadas-por-la-falta-de-oxigeno.html

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As winner of the young medicinal chemist meeting in Spain, Carles Galdeano was selected to present at the 3rd EFMC Young Medicinal Chemist Symposium. His talk was entitled “Drugging the Undrugguble: Targeting Challenging E3 Ligases”.  

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