On Monday 25th of October, Miriam has successfully defended her PhD thesis entitled Biophysical and structural approaches to discover small-molecule modulators of challenging targets in cancer. During her thesis she has employed a wide range of structural and biophysical methodologies to uncover ligandability of the E3 ligases family, including the discovery of the first FBXW7 […]

Read More →

Today, 11th of February we celebrate the day of women and girls in science. In order to achieve full and equal access to and participation in science for women and girls, and further achieve gender equality and the empowerment of women and girls, the United Nations General Assembly declared the 11 February as the International […]

Read More →

From the 10-13 of June in Krakow, is held the Joint Symposium on Medicinal Chemistry Frontiers. There, Salvatore and Míriam had the opportunity to show their work related to E3 Ligases. Salvatore presented a Poster entitled ” Drugging the FBW7 E3 Ligase with a Fragment-Based Approach” and Míriam gave a talk under the topic of […]

Read More →

From the 4th to the 6th of July the RICT 2018 conference was held in Strasbourg, which was devoted to “Interfacing Chemical Biology and Drug Discovery”. Míriam presented a poster entitled “Drugging Challenging E3 Ligases: A Novel Multidisciplinary Approach to Identify Small-Molecules that Bind Fbw7”. 

Read More →

On the 4th of May Ubiquitin Symposium&Friends took place in the Research Institute of Molecular Pathology in Vienna Biocenter. It was a great opportunity to discuss the state-of-the-art in the world of ubiquitin protein. Míriam presented a poster entitled “A Multidisciplinary Approach to Identify Small-Molecules Targeting the Fbw7 E3 Ligase”.

Read More →

On 19th of May the IV Simposio de Jóvenes Investigadores de la SEQT took place. Míriam presented a talk entitled “Drugging the Fbw7 E3 Ligase Allosterically: Towards New Chemical Probes”.     

Read More →