Our latest preprint is now available on ChemRxiv!

In this study, we investigate how hydrogen bonds contribute to the stability of molecular glue (MG)-induced ternary complexes. Our findings show that the strengthening of polar interactions is a consistent physicochemical mechanism that supports the action of chemically diverse MGs.

Based on these insights, we propose a new conceptual framework to better understand and classify molecular glues according to their structural role within the ternary complex.

We hope this work provides valuable guidance for the rational design of new MGs and accelerates their application in both biomedical and biotechnological fields.

Congratulations to Patricia Blanco Gabella for leading this study, and thanks to Varbina Ivanova, Álvaro Serrano-Morrás, and Julian Fuchs for their important contributions.