Neuroinflammation. PI: Josep Saura Martí

Presentation

The Neuroinflammation group is focused on the study of glial activation, a response of the nervous system with an inflammatory character that is triggered by various stimuli such as cell damage, abnormal protein aggregates or pathogens. The main cell players in this response are astrocytes and microglia. Dysfunction on the neuroinflammatory response, in particular a chronic exacerbation, may lead to neuronal damage and contribute to pathogenesis in a variety of neurological and psychiatric disorders.

Our aim is the discovery and study ok proteins playing pivotal roles in the neuroinflammatory response. Such proteins could become novel pharmacological targets for the treatment of diseases with a marked neuroinflammatory component such as Alzheimer’s and Parkinson’s disease, amyotrohic lateral sclerosis or multiple sclerosis. In the last years we have focused on the study of transcription factors which regulate proinflammatory gene expression in microglia and in membrane receptors which mediate neuro-microglia cross-talk.

Our group works in close contact with the “Cellular Neurobiology” group from IIBB, CSIC, led by Dr Carme Solà and also hosted at the Campus Clinic.  We work with a one-group/two-labs strategy. We share protocols and equipment, co-participate in projects and papers, co-direct PhD and master students and organize seminars in common.

Josep Saura Martí
Associate professor
josepsaura@ub.edu

Jose Manuel Vidal Taboada
Collaborating Professor
josevidalt@gmail.com

Tony Valente
Assistant professor
tonyvalente@gmail.com

Carme Sola Subirana

CSIC researcher
carme.sola@iibb.csic.es

Joan Serratosa Serdà
CSIC researcher
jssnmc@iibb.csic.es

Neus Rabaneda Lombarte
Doctoral researcher
neus.rabaneda@iibb.csic.es

Andrea Llaves López
Student of TFM
andrea.llalo24@gmail.com

  • Study of glial activation
  • Study of transcription factors that regulate the expression of pro-inflammatory genes in microglia
  • Study of membrane receptors that participate in the neuron microglia dialogue

  • Búsqueda de nuevas indicaciones terapéuticas en el ámbito de enfermedades neurodegenerativas y mitocondriales para el compuesto PPAR gamma agonista MIN-102

IP: Carme Solà Subirana
Ministerio de Ciencia, Innovación y Universidades (programa RETOS)
RTC-20175867-1
2018 - 2020
80.598 € (total granted 839.500,60)

  • C/EBPs microgliales como potencial diana terapéutica en la enfermedad de Parkinson

PI: Josep Saura Martí
Instituto de Salud Carlos III
PI14/302
2015 - 2017
110.715 €           

  • Nanoparticle delivery system for neurodegenerative disorders (European project; EURONANOMED 5th Call, 2014)

PI: Josep Saura Martí (Coordinator: Elena Kozlova, Uppsala University, Sweden)
Instituto de Salud Carlos III
AC14/00016
2015 - 2017
67.758 €

For more information for PI publications click in the link:
ORCID: https://orcid.org/0000-0002-5601-4466

Rabaneda-Lombarte N, Blasco-Agell L, Serratosa j, Ferigle L, Saura J, Solà C. Parkinsonian neurotoxicants impair the anti-inflammatory response induced by IL4 in glial cells: involvement of the CD200-CD200R1 ligand-receptor pair. Sci. Rep. 2020 Jun 30;10(1):10650. doi: 10.1038/s41598-020-67649-4. PMID: 32606391

Valente T, Dentesano G, Ezquerra M, Fernandez-Santiago R, Martinez-Martin J, Gallastegui E, Domuro C, Compta Y, Martí MJ, Bachs O, Márquez-Kisinousky L, Straccia M, Solà C, Saura J. (2020) CCAAT/enhancer binding protein δ is a transcriptional repressor of α-synuclein. Cell Death Differ. 27: 509-524, 2019 Jun 17. doi: 10.1038/ s41418-019- 0368-8. [Epub ahead of print]. PMID: 31209363.

Compta Y, Dias SP, Giraldo DM, Pérez-Soriano A, Muñoz E, Saura J, Fernández M, Bravo P, Cámara A, Pulido-Salgado M, Painous C, Ríos J, Martí MJ; CMSAR consortium. Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study. Parkinsonism Relat Disord. 2019 Aug;65:3-12. doi: 10.1016 /j.parkreldis. 2019.05.040. Epub 2019 Jun 3. PMID: 31178335.

Rabaneda-Lombarte N, Xicoy-Espaulella E, Serratosa J, Saura J, Solà C. Parkinsonian Neurotoxins Impair the Pro-inflammatory Response of Glial Cells. Front Mol Neurosci. 2019 Jan 10;11: 479. doi: 10.3389/ fnmol.2018. 00479. eCollection 2018. PMID: 30686998

Pulido-Salgado M, Vidal-Taboada JM, Barriga GG, Solà C, Saura J. RNA-Seq transcriptomic profiling of primary murine microglia treated with LPS or LPS + IFNγ. Sci Rep. 2018 Oct 31; 8(1): 16096. doi: 10.1038/ s41598-018- 34412-9. PMID: 30382133

Marchese D, Botta-Orfila T, Cirillo D, Rodriguez JA, Livi CM, Fernández-Santiago R, Ezquerra M, Martí MJ, Bechara E, Tartaglia GG; Catalan MSA Registry (CMSAR). Discovering the 3' UTR-mediated regulation of alpha-synuclein. Nucleic Acids Res. 2017 Dec 15; 45(22): 12888-12903. doi: 10.1093/ nar/gkx1048. PMID: 29149290

Compta Y, Giraldo DM, Muñoz E, Antonelli F, Fernández M, Bravo P, Soto M, Cámara A, Torres F, Martí MJ; Catalan MSA Registry (CMSAR). Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy. Parkinsonism Relat Disord. 2018 Jan; 46: 16-23. doi: 10.1016/ j.parkreldis.2017.10.010. Epub 2017 Oct 20. PMID: 29107645

Navarro G, Borroto-Escuela D, Angelats E, Etayo Í, Reyes-Resina I, Pulido-Salgado M, Rodríguez-Pérez AI, Canela EI, Saura J, Lanciego JL, Labandeira-García JL, Saura CA, Fuxe K, Franco R. Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia. Brain Behav Immun. 2018 Jan; 67:139-151. doi: 10.1016/ j.bbi.2017.08. 015. Epub 2017 Aug 24. PMID: 28843453

Valente T, Serratosa J, Perpiñá U, Saura J, Solà C. Alterations in CD200-CD200R1 System during EAE Already Manifest at Presymptomatic Stages.Front Cell Neurosci. 2017 May 4; 11:129. doi: 10.3389/ fncel.2017. 00129. eCollection 2017. PMID: 28522962

Pulido-Salgado M, Vidal-Taboada JM, Garcia Diaz-Barriga G, Serratosa J, Valente T, Castillo P, Matalonga J, Straccia M, Canals JM, Valledor A, Solà C, Saura J. Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis. J Neuroinflammation. 2017 Mar 16; 14(1): 54. doi: 10.1186/ s12974-017- 0834-5. PMID: 28302135

Pulido-Salgado M, Vidal-Taboada JM, Saura J. C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS. Prog Neurobiol. 2015 Sep; 132:1-33. doi: 10.1016/ j.pneurobio.2015.06. 003. Epub 2015 Jul 2. Review. PMID: 26143335

Compta Y, Valente T, Saura J, Segura B, Iranzo Á, Serradell M, Junqué C, Tolosa E, Valldeoriola F, Muñoz E, Santamaria J, Cámara A, Fernández M, Fortea J, Buongiorno M, Molinuevo JL, Bargalló N, Martí MJ. Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson's disease. J Neurol. 2015 Feb;262(2):294-306. doi: 10.1007/ s00415-014- 7560-z. Epub 2014 Nov 8. PMID: 25380583

Dentesano G, Serratosa J, Tusell JM, Ramón P, Valente T, Saura J, Solà C. CD200R1 and CD200 expression are regulated by PPAR-γ in activated glial cells. Glia. 2014 Jun; 62(6): 982-98. doi: 10.1002/ glia.22656. Epub 2014 Mar 17. PMID: 24639050

Straccia M, Dentesano G, Valente T, Pulido-Salgado M, Solà C, Saura J. CCAAT/enhancer binding protein β regulates prostaglandin E synthase expression and prostaglandin E2 production in activated microglial cells. Glia. 2013 Oct;  61(10): 1607-19. doi: 10.1002/ glia.22542. Epub 2013 Jul 25. PMID: 23893854

Valente T, Straccia M, Gresa-Arribas N, Dentesano G, Tusell JM, Serratosa J, Mancera P, Solà C, Saura J. CCAAT/enhancer binding protein δ regulates glial proinflammatory gene expression. Neurobiol Aging. 2013 Sep; 34(9): 2110-24. doi: 10.1016/ j.neurobiolaging. 2013.02.007. Epub 2013 Mar 21. PMID: 23523267

Mannara F, Valente T, Saura J, Graus F, Saiz A, Moreno B. Passive experimental autoimmune encephalomyelitis in C57BL/6 with MOG: evidence of involvement of B cells. PLoS One. 2012; 7(12): e52361. doi: 10.1371/ journal.pone. 0052361. Epub 2012 Dec 26. PMID: 23300649

Gresa-Arribas N, Viéitez C, Dentesano G, Serratosa J, Saura J, Solà C. Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents. PLoS One. 2012; 7(9): e45227. doi: 10.1371/ journal. pone. 0045227. Epub 2012 Sep 20. PMID: 23028862

Dentesano G, Straccia M, Ejarque-Ortiz A, Tusell JM, Serratosa J, Saura J, Solà C. Inhibition of CD200R1 expression by C/EBP β in reactive microglial cells. J Neuroinflammation. 2012 Jul 9;9: 165. doi: 10.1186/ 1742- 2094-9-165. PMID: 22776069

Pineda D, Ampurdanés C, Medina MG, Serratosa J, Tusell JM, Saura J, Planas AM, Navarro P. Tissue plasminogen activator induces microglial inflammation via a noncatalytic molecular mechanism involving activation of mitogen-activated protein kinases and Akt signaling pathways and AnnexinA2 and Galectin-1 receptors. Pineda D, Ampurdanés C, Medina MG, Serratosa J, Tusell JM, Saura J, Planas AM, Navarro P. Glia. 2012 Apr; 60(4): 526-40. doi: 10.1002/ glia.22284. Epub 2011 Dec 7. PMID: 22162045

Straccia M, Gresa-Arribas N, Dentesano G, Ejarque-Ortiz A, Tusell JM, Serratosa J, Solà C, Saura J. Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β. J Neuroinflammation. 2011 Nov 10;8: 156. doi: 10.1186/ 1742-2094-8-156. PMID: 22074460

Valente T, Mancera P, Tusell JM, Serratosa J, Saura J. C/EBPβ expression in activated microglia in amyotrophic lateral sclerosis. Neurobiol Aging. 2012 Sep; 33(9): 2186-99. doi: 10.1016/ j.neurobiolaging. 2011.09.019. Epub 2011 Oct 19. PMID: 22015310

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