Dr. Mercè Pallàs

pallas@ub.edu
Section of Pharmacology and Toxicology
Faculty of Pharmacy and Food Sciences
University of Barcelona
Tel. 93 4024531

ORCID: 0000-0003-3095-4254
https://orcid.org/0000-0003-3095-4254
Scopus Author ID:
7003835718
Researcher ID:   H-3129-2016

Mercè Pallàs

Neuropharmacology, neurodegeneration and ageing group is devoted to study molecular pathways implicated in neurodegenerative processes and to perform early preclinical studies in vitro and in vivo studying new compound to fight against Alzheimer’s disease and senescence. After working several years with non-pharmacological (Diet, exercise, caloric restriction) and pharmacological strategies (melatonin, resveratrol, sEH inhibitors, NMDA antagonist, Imidazoline I2 receptors ligands) in the context of aging, senescence and neurodegenerative diseases, as Alzheimer’s disease or Niemann-Pick C, the research group is currently interested in discern the precise mechanisms of action and the molecular pathways implicated of new drugs synthetized by ChemMedPharm group or other medical chemistry collaborators. Some of the pharmacological targets where we are looking for new drugs are soluble epoxide hydrolase and imidazoline 2 receptors.

Mercè Pallàs is Full Professor in Pharmacology in the Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences of the University of Barcelona (UB). He is also a founder member of the Institute of Neuroscience of the Universitat de Barcelona (NeuroUB). She has over 25 years’ experience working on preclinical pharmacology, with focus on cognitive decline in ageing and neurodegenerative diseases, such as Alzheimer’s disease (AD). After her PhD in the UB (1991), she spent one year (1992-93) at the Instituto di Ricerche Farmacologiche Mario Negri (Italy) working within the group of Prof. Daniela Corda on GPCR. He returned to Barcelona in 1993 as Associate Professor and was later promoted to Full Professor in 2011.

She has participated as PI in several research projects from public funding agencies and in some research contract with Spanish pharmaceutical companies. She is co-inventor in several patent and patent applications, both in new chemical entities with biological activity. So far she has supervised 18 PhD Thesis, and several MSc Research projects.

Her teaching activities have been mainly focused on topics related to Pharmacology, Neuropharmacology, Pharmacology in R+D+I and Ageing.

Linkedin

 

Team members

Dr Ana Guerrero López

Researcher Ramón y Cajal

Dra. Aina Bellver Sanchís

Post-doctoral researcher

Dra. Hildegard Colino Page

Post-doctoral researcher

Teresa Taboada

PhD Student

Marta Ribalta Vilella

PhD student

Alumni:
M Dolors Puigoriol-Illamola (PhD, 2020)
Foteini Vasilopoulou (PhD, 2021)
Júlia Companys-Alemany (PhD, 2022)

Júlia Jarné Ferrer (PhD, 2024)

Publications at a glance

  • Jarne-Ferrer J, Sánchez J, Codony S, Schneider M, Müller CE, Sanfeliu C, Franco R, Vazquez S, Griñán-Ferré C, Pallàs M. Novel Soluble Epoxide Hydrolase Inhibitor: Toward Regulatory Preclinical Studies. ACS Pharmacol Transl Sci. 2025 Jan 29;8(2):533-542. doi: 10.1021/acsptsci.4c00629. eCollection 2025 Feb 14. PMID: 39974649. Impact Factor: 5,0 (Q1).
  • Griñán-Ferré C, Bellver-Sanchis A, Guerrero A, Pallàs M. Advancing personalized medicine in neurodegenerative diseases: The role of epigenetics and pharmacoepigenomics in pharmacotherapy. Pharmacol Res. 2024 Jul;205:107247. doi: 10.1016/j.phrs.2024.107247. Epub 2024 Jun 2. PMID: 38834164. Impact Factor: 2,66 (Q1)
  • Griñán-Ferré C, Jarne-Ferrer J, Bellver-Sanchis A, Ribalta-Vilella M, Barroso E, Salvador JM, Jurado-Aguilar J, Palomer X, Vázquez-Carrera M, Pallàs M. Deletion of Gadd45a Expression in Mice Leads to Cognitive and Synaptic Impairment Associated with Alzheimer’s Disease Hallmarks. Int J Mol Sci. 2024 Feb 23;25(5):2595. doi: 10.3390/ijms25052595. PMID: 38473843; PMCID: PMC10931605. Impact Factor: 4,9 (Q1)
  • Griñán-Ferré C, Jarné-Ferrer J, Bellver-Sanchís A, Codony S, Puigoriol-Illamola D, Sanfeliu C, Oh Y, Lee S, Vázquez S, Pallàs M. Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer’s disease therapeutics. CNS Neurosci Ther. 2024 Apr;30(4):e14511. doi: 10.1111/cns.14511. Epub 2023 Oct 31. PMID: 37905690; PMCID: PMC11017401. Impact Factor: 4,8 (Q1)
  • Jarne-Ferrer J, Griñán-Ferré C, Bellver-Sanchis A, Vázquez S, Muñoz-Torrero D, Pallàs M. A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer’s Disease Mice Models. Pharmaceuticals (Basel). 2022 Jul 22;15(8):908. doi: 10.3390/ph15080908. PMID: 35893732; PMCID: PMC9394299. Impact Factor: 4,3 (Q1)
  • Companys-Alemany J, Turcu AL, Schneider M, Müller CE, Vázquez S, Griñán-Ferré C, Pallàs M. NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice. Cell Mol Life Sci. 2022 Jul 9;79(8):408. doi: 10.1007/s00018-022-04438-4. PMID: 35810220; PMCID: PMC9271115.Impact Factor: 6,3 (Q1)
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  • Cunillera T, Nuño N, Ballestero-Arnau M, Rodríguez-Herreros B, Rodríguez-Jiménez C, Pallàs M. Tuning the value of sweet food: Blocking sweet taste receptors increases the devaluation effect in a go/no-go task. Psychon Bull Rev. 2025 Feb 25. doi: 10.3758/s13423-025-02666-w. Online ahead of print. PMID: 40000597. Impact Factor: 4,8.
  • Yañez-Esparza A, Corona-Meraz FI, Mireles-Ramírez MA, Reyes-Mata MP, Martínez-Fernández C, Pallàs M, Griñan-Ferré C, Pavón L, Guerrero-García JJ, Ortuño-Sahagún D. Alterations in the miR-145/143 cluster expression in multiple sclerosis patients and their correlation with clinical variables. Mult Scler Relat Disord. 2025 Feb 23;96:106344. doi: 10.1016/j.msard.2025.106344. Online ahead of print. PMID: 40068475.
  • Irisarri A, Corral A, Perez-Salvador N, Bellver-Sanchis A, Ribalta-Vilella M, Bentanachs R, Alegret M, Laguna JC, Barroso E, Palomer X, Ortuño-Sahagún D, Vázquez-Carrera M, Pallàs M, Herrero L, Griñán-Ferré C. FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice. Mol Med. 2025 Feb 21;31(1):73. doi: 10.1186/s10020-025-01126-4. PMID: 39984825.
  • Puigoriol-Illamola D, Companys-Alemany J, McGuire K, Homer NZM, Leiva R, Vázquez S, Mole DJ, Griñán-Ferré C, Pallàs M. Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice. Pharmaceuticals (Basel). 2021 Oct 13;14(10):1040. doi: 10.3390/ph14101040. PMID: 34681264.
  • Griñán-Ferré C, Bellver-Sanchis A, Olivares-Martín M, Bañuelos-Hortigüela O, Pallàs M. Synergistic Neuroprotective Effects of a Natural Product Mixture against AD Hallmarks and Cognitive Decline in Caenorhabditis elegans and an SAMP8 Mice Model. Nutrients. 2021 Jul 14;13(7):2411. doi: 10.3390/nu13072411. PMID: 34371921.
  • Disease-modifying treatment with I2 imidazoline receptor ligand LSL60101 in an Alzheimer’s disease mouse model: a comparative study with donepezil. Vasilopoulou F, Rodríguez-Arévalo S, Bagán A, Escolano C, Griñán-Ferré C, Pallàs M. Br J Pharmacol. 2021 Aug;178(15):3017-3033. doi: 10.1111/bph.15478. Epub 2021 May 24. PMID: 33817786.
  • Griñán-Ferré C, Companys-Alemany J, Jarné-Ferrer J, Codony S, González-Castillo C, Ortuño-Sahagún D, Vilageliu L, Grinberg D, Vázquez S, Pallàs M. Inhibition of Soluble Epoxide Hydrolase Ameliorates Phenotype and Cognitive Abilities in a Murine Model of Niemann Pick Type C Disease. Int J Mol Sci. 2021 Mar 26;22(7):3409. doi: 10.3390/ijms22073409. PMID: 33810307.
  • Griñán-Ferré C, Bellver-Sanchis A, Izquierdo V, Corpas R, Roig-Soriano J, Chillón M, Andres-Lacueva C, Somogyvári M, Sőti C, Sanfeliu C, Pallàs M. The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy.  Ageing Res Rev. 2021 May;67:101271. doi: 10.1016/j.arr.2021.101271. Epub 2021 Feb 8. PMID: 33571701.
  • Vasilopoulou F, Griñán-Ferré C, Rodríguez-Arévalo S, Bagán A, Abás S, Escolano C, Pallàs M. I2 imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway. Geroscience. 2021 Apr;43(2):965-983. doi: 10.1007/s11357-020-00281-2. Epub 2020 Oct 31. PMID: 33128688.
  • Vasilopoulou F, Bagan A, Rodriguez-Arevalo S, Escolano C, Griñán-Ferré C, Pallàs M. Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I2-Imidazoline Receptor Ligand MCR5. Pharmaceutics. 2020 May 23;12(5):475. doi: 10.3390/pharmaceutics12050475.
    PMID: 32456135.
  • Puigoriol-Illamola D, Martínez-Damas M, Griñán-Ferré C, Pallàs M. Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice. Int J Mol Sci. 2020 Feb 10;21(3):1154. doi: 10.3390/ijms21031154. PMID: 32050516.
  • Griñán-Ferré C, Marsal-García L, Bellver-Sanchis A, Kondengaden SM, Turga RC, Vázquez S, Pallàs M. Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer’s disease mouse model. Aging (Albany NY). 2019 Dec 4;11(23):11591-11608. doi: 10.18632/aging.102558. Epub 2019 Dec 4. PMID: 31804189.
  • Griñán-Ferré C, Vasilopoulou F, Abás S, Rodríguez-Arévalo S, Bagán A, Sureda FX, Pérez B, Callado LF, García-Sevilla JA, García-Fuster MJ, Escolano C, Pallàs M. Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice. Neurotherapeutics. 2019 Apr;16(2):416-431. doi: 10.1007/s13311-018-00681-5. PMID: 30460457
  • Griñán-Ferré C, Corpas R, Puigoriol-Illamola D,Palomera-Ávalos V, Sanfeliu C, Pallàs M. Understanding epigenetics in the neurodegeneration of Alzheimer’s disease: SAMP8 mouse model. Journal of Alzheimer´s Disease. 2018;62(3):943-963. doi: 10.3233/JAD-170664. Impact Factor: 3,731 (Q1).
  • Puigoriol-Illamola D, Griñán-Ferré C, Vasilopoulou F, Leiva R, Vázquez S, Pallàs M. 11β-HSD1 inhibition by RL-118 Promotes Autophagy and Correlates with Reduced Oxidative Stress and Inflammation, Enhancing Cognitive Performance in SAMP8 mouse model. Molecular Neurobiology. 2018;55(12):8904-8915. doi: 10.1007/s12035-018-1026-8 Impact Factor: 5,096 (Q1).
  • Corpas R, Griñán-Ferré C, Rodríguez-Farré E, Pallàs M, Sanfeliu C. Resveratrol induces brain resilience against Alzheimer neurodegeneration through proteostasis enhancement. Molecular Neurobiology. 56(2):1502-1516. doi: 10.1007/s12035-018-1157-y.  2019 :56(2):1502-1516. doi: 10.1007/s12035-018-1157-y. Impact Factor: 5,096 (Q1).
  • Corpás R, Griñán-Ferré C, Palomera V,Porquet D, García de Frutos P, Franciscato-Cozzolino SM, Rodríguez-Farré E, Pallàs M, Sanfeliu C, Cardoso BR. Melatonin induces mechanisms of brain resilience against neurodegeneration. Journal of Pineal Research.  2018 ;65(4):e12515. doi: 10.1111/jpi.12515  Impact Factor: 15,221 (D1).
  • Griñán-Ferré C, Izquierdo V, Otero E, Puigoriol-Illamola D, Corpás R, Sanfeliu C, Ortuño-Sahagún D, Pallàs M. Environmental enrichment improves cognitive deficits, AD hallmarks and epigenetic alterations presented in female 5xFAD mice model: A synergistic effect against neurodegeneration. Frontiers in Cellular Neuroscience. 2018,12:224. doi: 10.3389/fncel.2018.00224 Impact Factor: 4,555 (Q1).
  • Cosín-Tomás M, Álvarez-López MJ, Companys-Alemany J, Kaliman P, González-Castillo C, Ortuño-Sahagún D, Pallàs M, Griñán-Ferré, C. Temporal integrative analysis of mRNA and microRNAs expression profiles and epigenetic alterations in female SAMP8, a model of age-related. Frontiers in Genetics. 2018;9:596. doi: 10.3389/fgene.2018.00596. Impact Factor: 4,151 (Q1)
  • Palomera-Ávalos V, Griñán-Ferré C, Izquierdo V, Camins A, Sanfeliu C, Canudas AM, Pallàs M. Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain. Experimental Gerontology,  2018, 102:3-11. doi: 10.1016/j.exger.2017.11.014.  Impact Factor: 3,35 (Q1).
  • Akiguchi I, Pallàs M, Budka H, Akiyama H, Ueno M, Han J, Yagi H, Nishikawa T, Chiba Y, Sugiyama H, Takahashi R, Unno K, Higuchi K, Hosokawa M. SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda’s legacy and future directions. Neuropathology. 2017 Aug;37(4):293-305. doi: 10.1111/neup.12373
  • Palomera-Ávalos V, Griñán-Ferré C, Izquierdo V, Camins A, Sanfeliu C, Pallàs M. Metabolic stress induces cognitive disturbances and inflammation in aged mice: role of resveratrol. Rejuvenation Research, 2017 20(3):202-217. doi: 10.1089/rej.2016.1885. Impact Factor: 3,311 (Q1).
  • Leiva R, Griñan-Ferré C, Seira C, Valverde E, McBride A, Binnie M, Pérez B, Luque FJ, Pallàs M, Bidon-Chanal A, Webster SP, Vázquez S. Design, synthesis and in vivo study of novel pyrrolidine-based 11β-HSD1 inhibitors for age-related cognitive dysfunction. Eur J Med Chem 2017 20;139:412-428. doi: 10.1016/j.ejmech.2017.08.003. Impact Factor: 4,519 (Q1).
  • Griñan-Ferré C, Pérez-Cáceres D, Gutiérrez-Zetina SM, Camins A, Palomera-Avalos V, Ortuño-Sahagún D, Rodrigo MT, Pallàs, M.  Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8). Molecular Neurobiology 2016:53(4):2435-50. doi: 10.1007/s12035-015-9210-6.Impact Factor:  6,190  (Q1).
  • Palomera-Ávalos V, Griñán-Ferré C, Puigoriol-Ilamola D, Camins A, Sanfeliu C, Canudas AM, Pallàs M. Resveratrol Protects SAMP8 Brain Under Metabolic Stress: Focus on Mitochondrial Function and Wnt Pathway. Molecular Neurobiology.  2017 54(3):1661-1676. doi: 10.1007/s12035-016-9770-0. Impact Factor: 5,096 (Q1).
  • Griñán-Ferré C, Palomera-Ávalos V, Puigoriol-Illamola D, Camins A, Porquet D, Pla V, Aguado F, Pallàs M. Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelereated senescence. Experimental Gerontology. 2016 80:57-69. doi: 10.1016/j.exger.2016.03.014. Impact Factor : 3,35 (Q1).
  • Griñan-Ferré C, Puigoriol-Illamola D,  Palomera-Ávalos V, Pérez-Cáceres D, Companys J, Camins A, Ortuño-Sahugún D, Rodrigo  MT, Pallàs M. Environmental enrichment modified epigenetic mechanisms in SAMP8 mouse hippocampus by reducing oxidative stress and inflammaging and achieving neuroprotection.  Frontiers in Aging Neuroscience. 2016 18;8:241. doi: 10.3389/fnagi.2016.00241. Impact Factor : 4,348 (Q1).
  • Griñán-Ferré C, Sarroca S, Ivanova A, Camins A, Sanfeliu C, Pallas M. Epigenetic mechanisms underlying cognitive impairment and Alzheimer’s disease hallmarks in 5XFAD mice.  Aging 2016 (4):664-84. DOI: 10.18632/aging.100906. Impact Factor: 6,432 (Q1).

Selected Projects

New insights on I2 imidazoline receptors role in neuroinflammation. Identification and validation as a target for Alzheimer’s disease Ministerio de Economia y Competitividad  PID2022-138079OB-100. Funds: 190.000,00 From 2022 to 2025. PI: Mercè Pallàs               

Understanding the Contribution of Cellular Senescence to Alzheimer’s Disease Ministerio de Economia y Competitividad  PID2022-138829OA-100 Funds: 170.000,00 From 2022 to 2025. PI Ana Guerrero Lopez

Validation of a first in class candidate of a soluble epoxide hydrolase inhibitor to treat Alzheimer’s disease. Ministerio de Economia y Competitividad  PDC2021-121096-C21. Funds: 150.000,00 From 2021 to 2023. PI: Mercè Pallàs               

Soluble Epoxide hydrolase modulation in brain and peripheral tissues Ministerio de Economía y Competitividad.  Ministerio de Economía y Competitividad PID2019-106285RB-C21. Funds: 133.100,00 From 2019 to 2022. PI: Mercè Pallàs

Estudio de una nueva diana farmacológica para la enfermedad de Alzheimer: modulación del estrés oxidativo y la función mitocondrial.SAF2016-77703-C2-1-R. Funds: 133.100,00 from: 2016 to:2019

Identificación de moduladores dietéticos del envejecimiento cognitivo y plasticidad cerebral, y evidencia del concepto de eficacia en la prevención/reversión del declive cognitivo. Ministerio de Economía y Competitividad. Universidad de Barcelona PCIN-2015-229 Funds: 120.000, from: 2016 from: 2018. PI: Mercè Pallas

Evaluación de la eficacia de inhibidores epigenéticos en modelos experimentales de patologías humana. Ministerio de Economía y Competitividad. Biomedicina (SAF) RETOS-COLABORACIÓN, dentro del Programa Estatal de Investigación, Desarrollo e innovación Orientada a los Retos de la Sociedad. Convocatoria 2015 ORYZON Genomics S.L./UB PI: Mercè Pallas /UAB de Barcelona. SRTC1500C003898XV0

Medicinal Chemistry and Pharmacology of Neurodegenerative Diseases SGRC – Ajuts de Suport als Grups de Recerca de Catalunya (SGR) – Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) 2017SGR106 Funds 20.000,00 , from: 2017 from: 2020. PI. Diego Muñoz-Torrero López-Ibarra

Regulación epigenética de la respuesta inflamatoria (RETOS COLABORACION) 2016 – 2018. Ref.RTC-2016-4955-1. Ministerio de Economia y Competitividad . IF: Mercè Pallàs

projects

Contracts

Products in cognitive decline by using the senescence-accelerated murine P8 model (SAMP8) Biosearch S.A.  Funds:37.073,17  From  2019 to 2020. Merce Pallas Lliberia

Products SDP on aging-hallmarks by using the Caenorhabditis elegans (C. elegans) APC EUROPE, S.A.      Funds:15.158,28. From    2020 to 2021. PI. Merce Pallas Lliberia; Christian Griñán Ferré

A New family of sEH inhibitors for AD. CI17-00053 Fundació Caixa de Pensions ‘La Caixa’ Funds: 57.851,24 , from: 2017 From: 2019 PI: Mercè Pallàs; Carlos Galdeano

Novel compounds for the treatment of neurodegenerative disorders. CI18-00002 Fundació Caixa de Pensions ‘La Caixa’ Funds: 70.000 From: 2018 to: 2020 PI: Mercè Pallàs; Maria Carmen Escolano

Study of OG-S436 and OG-S437 effects on behavior. Cerebro espinal Fluid extraction in the senescence accelerated murine P8 model. Oryzon Genomics, S.A Funds: 69,907.75 , from: 2015 from: 2016 PI: Mercè Pallàs

Study of neuroprotective role of OG-S436 in the senescence accelerated murine P8 model. Oryzon Genomics, S.A Funds: 5.674,12, from: 2015 to: 2016 PI: Mercè Pallas

Study of anxiolytic activity of OG-S09 in the senescence accelerated murine P8 model. Oryzon Genomics, S.A Funds: 14.895, from: 2015 to : 2015 PI: Mercè Pallas

A New family of sEH inhibitors for AD. CI17-00053 Fundació Caixa de Pensions ‘La Caixa’ Funds: 57.851,24 , from: 2017 to: 2019 PI: Mercè Pallàs; Carlos Galdeano

Novel compounds for the treatment of neurodegenerative disorders. CI18-00002 Fundació Caixa de Pensions ‘La Caixa’ Funds: 70.000 From: 2018 to: 2020 PI: Mercè Pallàs; Maria Carmen Escolano

Products in cognitive decline by using the senescence-accelerated murine P8 model (SAMP8). Biosearch S.A. Funds: 073,17 €1 From: 2019 to: 2020. PI: Mercè Pallàs

Efficacy study of compounds OG-S2323, OG-S2324 and OG-S2325 on memory and social behavior in SAMP8 mice. Oryzon Genomics, S.A. Funds: 464,50 € From: 2019 to: 2020 PI: Mercè Pallàs

 

Patents

Compounds as soluble epoxide hydrolase inhibitors.  Gisbert, Sandra; Griñán Ferré, Cristian Gaspar; Pallàs Lliberia, Mercè; Vázquez Cruz, Santiago. EP21382237.2. March 24, 2021.

G9a inhibitors. Griñán-Ferré, C.; Pallàs, M.; Bellver, A.; Escolano, C.; Vázquez, S.; Barbaraci. C. EP23382641, June 22, 2023.

Secreted splicing variant of klotho for treating bone disorders.Roig Soriano, Joan; Chillón Rodríguez, Miguel; Bosch Merino, Assumpció; Pallàs Lliberia, Mercè; Griñán Ferré, Christian Gaspar. EP21382465.9. May 25, 2021.

Dual G9a/GSK-3B inhibitors. Ferré, Christian Gaspar; Bellver Sanchis, Aina; Pallàs Lliberia, Mercè; Ribalta Vilella, Marta; Vázquez Cruz, Santiago; Escolano Mirón, María Carmen; Sánchez Arfelis, Ainoa. EP24382375.4. April 10, 2024.
Synthetic I2 Imidazoline receptor ligands for prevention or treatment of human brain disorders.

María Carmen Escolano, Mercè Pallàs Lliberia, Christian Gaspar Griñán Ferré, Sònia Abás, Luis-Felipe Callado Hernando, Jesús A. García Sevilla.
PCT/EP2018/085742.

Methods of treating behavior alterations.
Tamara Maes, David Rotllant Pozo, Christian Griñán-Ferré, Mercè Pallàs Lliberia, Roser Nadal Alemany, Antonio Armario García.
PCT/EP2019/071120.
Pub. NO.: WO/2019/025588

Composiciones para uso en el tratamiento de trastornos cognitivos.
Mónica Olivares Martín. Luis Pérez Martínez. Óscar Bañuelos Hortigüela. José Luís López Larramendi. Mercè Pallàs Lliberia. Cristian Gaspar Griñan Ferre.
PCT/ES2020/070005.

Collaborations

Dra. Gemma Navarro.Department of Biochemistry and Physiology. Faculty of Pharmacy and Food Sciences. University of  Barcelona and. CIBERNED

Dr Coral Sanfeliu Institute of Biomedical Research of Barcelona (IBB), CSIC and IDIBAPS, Barcelona, Spain. And CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Dr Daniel Ortuño Sahagún Instituto de Investigación en Ciencias Biomédicas (IICB) Departamento de Biología Molecular y Genómica Centro Universitario de Ciencias de la Salud Universidad de Guadalajara. Mexico.

Dr Ana Coto Montes Departamento de Morfologia y Biología Celular. Universidad de Oviedo. España

Dr Gemma Casadesus   Florida University. Gainsvilñe, USA

Dr B.D. Hammock and Dr. C. Morisseau Department of Entomology and Nematology and Comprehensive Cancer Center, University of California, Davis, California, USA.

NeuroEpigenetics

This constitutes a new research line initiated by Dr. Christian Griñán-Ferré, by using C. elegans, as well as several mice models…

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