Aniline-based inhibitors of influenza H1N1 virus acting on hemagglutinin-mediated fusion
April 3, 2020
J. Med. Chem. 61:98-118, 2018. Abstract. Two series of easily accessible anilines were identified as inhibitors of influenza A virus…
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Exploring the size of the lipophilic unit of the soluble epoxide hydrolase inhibitors.
April 3, 2020
Bioorg. Med. Chem. 27:115078, 2019. Abstract. Soluble epoxide hydrolase (sEH) inhibitors are potential drugs for several diseases. Adamantyl ureas are…
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds
April 2, 2020
Camps, P.; Formosa, X. ; Galdeano, C.; Muñoz-Torrero, D.; Ramírez, L.; Gómez, E.; Isambert, N.; Lavilla, R.; Badia, A.; Clos,…
Novel levetiracetam derivatives that are effective against the Alzheimer-like phenotype in mice: synthesis, in vitro, ex vivo and in vivo efficacy studies
April 2, 2020
Sola, I.; Aso, E.; Frattini, D.; López-González, I.; Espargaró, A.; Sabaté, R.; Di Pietro, O.; Luque, F. J.; Clos, M.…
Design, synthesis, and multitarget biological profiling of second generation anti-Alzheimer rhein-huprine hybrids
April 2, 2020
Pérez-Areales, F. J.; Betari, N.; Viayna, A.; Pont, C.; Espargaró, A.; Bartolini, M.; De Simone, A.; Rinaldi Alvarenga, J. F.;…
First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents
April 2, 2020
Alencar, N.; Sola, I.; Linares, M.; Juárez-Jiménez, J.; Pont, C.; Viayna, A.; Vílchez, D.; Sampedro, C.; Abad, P.; Pérez-Benavente, S.;…
A novel class of multitarget anti-Alzheimer benzohomoadamantane_chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
April 1, 2020
Pérez-Areales, F. J.; Turcu, A. L.; Barniol-Xicota, M.; Pont, C.; Pivetta, D.; Espargaró, A.; Bartolini, M.; De Simone, A.; Andrisano,…
Direct imaging of fungal infection in human pulmonary tissue with spacer-free BODIPY labelled antimicrobial peptides.
April 1, 2020
Mendive-Tapia, L.; Zhao, C.; Akram, A. R.; Preciado, S.; Albericio, F.; Lee, M.; Serrels, A.; Kielland, N.; Read, N. D.;…
Insertion of Isocyanides into N-Si bonds: Azine MultiComponent Reactions Leading to Potent Anti-parasitic Compounds.
April 1, 2020
Kishore, K. G. Ghashghaei, O.; Estarellas, C.; Mestre, M. M.; Monturiol, C.; Kielland, N.; Kelly, J. M.; Francisco, A. F.;…
Constrained Cyclopeptides: Biaryl Formation through Pd-catalyzed C-H Activation in Peptides. Structural Control of the Cyclization vs Cyclodimerization Outcome.
April 1, 2020
Mendive-Tapia, L.; Bertran, A.; García, J.; Acosta, G.; Albericio, F.; Lavilla. R. Chemistry, a European Journal. 2016, 22(37), 13114-13119; DOI:…
Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in app/ps1 mice used as a model of familial Alzheimer’s disease
April 1, 2020
Aso, E.; Semakova, J.; Joda, L.; Semak, V.; Halbaut, L.; Calpena, A.; Escolano, C.; Perales, J. C.; Ferrer, I. Current…
Easy access to (2-imidazolin-4-yl)phosphonates by a microwave assisted multicomponent reaction
April 1, 2020
Abas, S.; Estarellas, C.; Luque, F. J.; Escolano, C. Tetrahedron, 2015, 71(19), 2872-2881. Link: https://www.sciencedirect.com/science/article/abs/pii/S0040402018300188