Publications

Publications

Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer’s disease therapeutics

Griñán-Ferré, Christian; Jarné-Ferrer, Júlia; Bellver-Sanchís, Aina; Codony, Sandra; Puigoriol-Illamola, Dolors; Sanfeliu, Coral; Oh, Yumin; Lee, Seulki; Vázquez, Santiago; Pallàs, Mercè

DOI: 10.1111/cns.14511

Neuroinflammation is widely recognized as a significant hallmark of Alzheimer’s disease (AD). To combat neuroinflammation, the inhibition of the soluble epoxide hydrolase (sEH) enzyme has been demonstrated crucial. Importantly, sEH in-hibition could be related to other neuroprotective pathways described in AD.

Selected Publications

Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress

Mona Peyman, Emma Barroso, Andreea L. Turcu, Francesc Estrany Jr., Dáire Smith, Javier Jurado-Aguilar, Patricia Rada, Christophe Morisseau, Bruce D.…

Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer’s disease therapeutics

Griñán-Ferré, Christian; Jarné-Ferrer, Júlia; Bellver-Sanchís, Aina; Codony, Sandra; Puigoriol-Illamola, Dolors; Sanfeliu, Coral; Oh, Yumin; Lee, Seulki; Vázquez, Santiago; Pallàs, Mercè DOI: 10.1111/cns.14511 Neuroinflammation is widely recognized as a significant…

Design and Synthesis of AMPK Activators and GDF15 Inducers

Zhang, Meijian; Bagan, Andrea; Martinez, Donna; Barroso, Emma; Palomer, Xavier; Vazquez, Santiago; Escolano, Carmen; Vazquez-Carrera, Manuel DOI: 10.3390/molecules28145468 Targeting growth differentiation factor 15 (GDF15) is a recent…

A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid-State NMR

Μarianna Stampolaki, Anja Hoffmann, Kumar Tekwani, Kyriakos Georgiou, Christina Tzitzoglaki, Chunlong Ma, Stefan Becker, Patrick Schmerer, Kristin Döring, Ioannis Stylianakis, Andreea L. Turcu, Jun Wang, Santiago Vázquez, Loren B. Andreas, Michaela Schmidtke, Antonios Kolocouris DOI:…