Conferenciant: James Mansfield, Scientific Director at Magnetic Insight Inc.
Resum: Advances in cancer immunotherapy have fueled a boom in immuno-oncology research. There is an urgent need to track and accurately quantify cells in vivo. In addition, researchers need a method to systematically measure the biodistribution of immune cells in solid tumors over time.
Magnetic Particle Imaging (MPI) is a novel preclinical imaging technique used to non-invasively track iron-oxide-tagged immune cells in vivo.
Track in vivo the biodistributions of macrophages, other immune cells, stem cells, tumor cells for weeks or even months. The data is specific and quantitative. Data acquisition from nanoparticles can be combined with MRI or CT. Researchers can generate localized hyperthermia zones, as therapy or as an adjunct to radiation or immune therapies.
Magnetic Particle Imaging can be used for:
- In vivo systemic tracking and quantitation of immune (and other) cells in 3D
- Localized RF hyperthermia for tumor immunogenesis and nanoparticle actuation
- Drug delivery monitoring and image-guided theragnostics Results from immune cell tracking, in vivo quantitation, drug-delivery monitoring and localized hyperthermia will be discussed.
