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One of the most important traits associated to the development of early Homo sapiens and Neanderthal populations relates to the use of fire on a regular basis and as a center to carry out their main social and economic activities. This sub-line of research focuses mainly on the use of plants by these, and later populations, and particularly on the use of fire and their pirotechnological capacities. Some of the sites that have been the focus of these studies include Pinnacle Point (South Africa), Quebrada site (Valencia), Mughr el-Hamamah (Jordan), etc. In addition we just opened a new line of research focusing on the use of plants by these populations for medicinal and curative purposes.